Changes of bivalent chromatin coincide with increased expression of developmental genes in cancer

Autor: Bernhart, S. (Stephan H), Kretzmer, H. (Helene), Holdt, L. (Lesca M), Juehling, F. (Frank), Ammerpohl, O. (Ole), Bergmann, A. (Anke K), Northoff, B. (Bernd H), Doose, G. (Gero), Siebert, R. (Reiner), Stadler, P. (Peter F), Hoffmann, S. (Steve)

Publikováno v: Scientific Reports
Scientific Reports, 2016, 6 (1), ⟨10.1038/srep37393⟩
Scientific reports 6:37393 Doi: 10.1038/srep37393

Bivalent (poised or paused) chromatin comprises activating and repressing histone modifications at the same location. This combination of epigenetic marks at promoter or enhancer regions keeps genes expressed at low levels but poised for rapid activa

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