Longitudinal trends in thyroid function in relation to iodine intake: ongoing changes of thyroid function despite adequate current iodine status

Autor: Suzanne Holewijn, H. Alec Ross, Doorléne T. H. van Tienoven, Bart L A Kiemeney, Johannes W Smit, Jack F. M. Wetzels, R.T. Netea-Maier, Teun van Herwaarden, Jacqueline de Graaf, Ad R M M Hermus, Annenienke C van de Ven, Fred C. G. J. Sweep, Martin den Heijer

Publikováno v: European Journal of Endocrinology, 170(1), 49-54. BioScientifica Ltd.
van de Ven, A C, Netea-Maier, R T, Ross, H A, van Herwaarden, T A E, Holewijn, S, de Graaf, J, Kiemeney, B L A, van Tienoven, D, Wetzels, J F M, Smit, JW, Sweep, F C G J, Hermus, A R M M & den Heijer, M 2014, ' Longitudinal trends in thyroid function in relation to iodine intake: ongoing changes of thyroid function despite adequate current iodine status ', European Journal of Endocrinology, vol. 170, no. 1, pp. 49-54 . https://doi.org/10.1530/EJE-13-0589
European Journal of Endocrinology, 22, pp. 49-54
European Journal of Endocrinology, 22, 49-54

ObjectiveSeveral cross-sectional studies on populations with iodine deficiency showed that TSH-levels are negatively associated with age, while in populations with high iodine intake TSH is positively associated with age. The question is whether such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::713c964da633a66a2cc27d23c9d2fb03
https://doi.org/10.1530/eje-13-0589

The Prognostic Value of BCAR1 in Patients with Primary Breast Cancer

Autor: D. de Jong, Jan G. M. Klijn, H. Portengen, Doorléne T. H. van Tienoven, Fred C. G. J. Sweep, Simone P. J. van Broekhoven, Lambert C. J. Dorssers, Nicolai Grebenchtchikov, Paul N. Span, H. A. Peters, Arend Brinkman, Marion E. Meijer-van Gelder, John A. Foekens, Anneke Geurts-Moespot, Maxime P. Look

Publikováno v: Clinical Cancer Research, 10, 18 Pt 1, pp. 6194-202
Clinical Cancer Research, 10, 6194-6202. American Association for Cancer Research Inc.
Clinical Cancer Research, 10, 6194-202

Purpose: BCAR1, the human homologue of the rat p130Cas protein, was identified in a functional screen for human breast cancer cell proliferation resistant to antiestrogen drugs. Here, we study the prognostic value of quantitative BCAR1 levels in a la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4740c7b3086949f8b422e1dc8f53f957
https://doi.org/10.1158/1078-0432.ccr-04-0444

The complex between urokinase-type plasminogen activator (uPA) and its type-1 inhibitor (PAI-1) independently predicts response to first-line endocrine therapy in advanced breast cancer

Autor: Nicolai Grebenchtchikov, Vivianne C. G. Tjan-Heijnen, Doorléne T. H. van Tienoven, Peggy Manders, Paul N. Span, Louk V.A.M. Beex, Fred C. G. J. Sweep, Anneke Geurts-Moespot

Publikováno v: Thrombosis and Haemostasis. 91:514-521

SummaryIt has been shown that urokinase-type plasminogen activator (uPA) and its main inhibitor (PAI-1) have predictive value for therapy success in advanced breast cancer. Levels of the complex between uPA and PAI-1, formed when both molecules are i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e2bd1d790ecdb98f1c5e75ed837fe16
https://doi.org/10.1160/th03-07-0467

High survivin predicts a poor response to endocrine therapy, but a good response to chemotherapy in advanced breast cancer

Autor: Doorléne T. H. van Tienoven, Jeffrey Lehr, Paul N. Span, V.C.G. Tjan-Heijnen, Peggy Manders, Fred C. G. J. Sweep

Publikováno v: Breast Cancer Research and Treatment, 98, 2, pp. 223-30
Breast Cancer Research and Treatment, 98, 223-30

Contains fulltext : 50262.pdf (Publisher’s version ) (Closed access) Variants of survivin with differing subcellular localizations might mediate the different functions of survivin, i.e. cell-cycle regulation and apoptosis inhibition. Highly prolif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebb0090ef6ce710f31021ecb5ee7ed3
https://hdl.handle.net/2066/50262

Vascular endothelial growth factor independently predicts the efficacy of postoperative radiotherapy in node-negative breast cancer patients

Autor: Peggy, Manders, Fred C G J, Sweep, Vivianne C G, Tjan-Heijnen, Anneke, Geurts-Moespot, Doorléne T H, van Tienoven, John A, Foekens, Paul N, Span, Jan, Bussink, Louk V A M, Beex

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 9(17)

Vascular endothelial growth factor (VEGF) is a mediator of angiogenesis and is up-regulated under hypoxic conditions. Hypoxic tumors are known to exhibit resistance to radiotherapy. We investigated the association between VEGF levels in tumor tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f14daf0f611f6547f216050198418bac
https://pubmed.ncbi.nlm.nih.gov/14695136