Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Doona Song"'
Autor:
Jinsei Jung, Shin Hye Noh, Sungwoo Jo, Doona Song, Min Jin Kang, Mi Hwa Shin, Hyun Jae Lee, Jae-Chul Pyun, Wan Namkung, Gyoonhee Han, Min Goo Lee, Jae Young Choi
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115445- (2023)
Variants in SLC26A4 (pendrin) are the most common reasons for genetic hearing loss and vestibular dysfunction in East Asians. In patients with Pendred syndrome and DFNB4 (autosomal recessive type of genetic hearing loss 4), caused by variants in SLC2
Externí odkaz:
https://doaj.org/article/4959a1ba140a46e0a84a1435d1f205d7
Autor:
Yechan Lee, Sunhee Lee, Younho Lee, Doona Song, So-Hyeon Park, Jieun Kim, Wan Namkung, Ikyon Kim
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 231 (2024)
The epidermal growth factor receptor (EGFR), also known as ErbB1 and HER1, belongs to the receptor tyrosine kinase family. EGFR serves as the primary driver in non-small-cell lung cancer (NSCLC) and is a promising therapeutic target for NSCLC. In thi
Externí odkaz:
https://doaj.org/article/25afb50b92b64f0a88bdb9c7b8689080
Autor:
Yonghyo Kim, Yutaka Sugihara, Tae Young Kim, Sung Min Cho, Jin Young Kim, Ju Yeon Lee, Jong Shin Yoo, Doona Song, Gyoonhee Han, Melinda Rezeli, Charlotte Welinder, Roger Appelqvist, György Marko-Varga, Ho Jeong Kwon
Publikováno v:
Biomolecules, Vol 10, Iss 4, p 508 (2020)
Although natural products are an important source of drugs and drug leads, identification and validation of their target proteins have proven difficult. Here, we report the development of a systematic strategy for target identification and validation
Externí odkaz:
https://doaj.org/article/c0c1eaf16c404d448dab81d12e8deefa
Autor:
Won Chan, Hwang, Doona, Song, Hyesung, Lee, Changmok, Oh, Seong Hun, Lim, Hyeon Jeong, Bae, Nam Doo, Kim, Gyoonhee, Han, Do Sik, Min
Publikováno v:
Experimental & Molecular Medicine. 54:1563-1576
Phospholipase D (PLD) is a potential therapeutic target against cancer. However, the contribution of PLD inhibition to the antitumor response remains unknown. We developed a potent and selective PLD1 inhibitor based on computer-aided drug design. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dce24ea0eb52c551ebf0430697d0f8d
https://doi.org/10.1038/s12276-022-00853-6
https://doi.org/10.1038/s12276-022-00853-6
Publikováno v:
Bioorganic chemistry. 130
Ras protein has been considered a fascinating target for anticancer therapy because its malfunction is closely related to cancer. However, Ras has been considered undruggable because of the failure to regulate its malfunction by controlling the Ras a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e48e4a80c9fa322b98869ca17d2ab5
https://pubmed.ncbi.nlm.nih.gov/36375353
https://pubmed.ncbi.nlm.nih.gov/36375353
Autor:
Yong Kee Kim, Gyoonhee Han, Jee Won Hwang, Gyu-Un Bae, Su-Nam Kim, Nayeon Myung, Mark T. Bedford, Doona Song
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology
Communications Biology
PRMT5 participates in various cellular processes, including transcription regulation, signal transduction, mRNA splicing, and DNA repair; however, its mechanism of regulation is poorly understood. Here, we demonstrate that PRMT5 is phosphorylated at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a1c69ec3b3ade50be775579d4a8eaf
http://link.springer.com/article/10.1038/s42003-020-01157-z
http://link.springer.com/article/10.1038/s42003-020-01157-z
Autor:
Jae Young Choi, Moo Suk Park, Yoon Kyung Jeon, Ji-Hwan Ryu, Young-Min Hyun, Jinhong Park, Doona Song, Mia Gi, Gyoonhee Han, Wan Namkung, Eun Hye Lee, Mi Hwa Shin, Je Kyung Seong
Publikováno v:
Theranostics
Rationale: Pendrin is encoded by SLC26A4 and its mutation leads to congenital hearing loss. Additionally, pendrin is up-regulated in inflammatory airway diseases such as chronic obstructive pulmonary disease, allergic rhinitis, and asthma. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8871070eee9cbb7b8c07e823c858de90
https://doi.org/10.7150/thno.46417
https://doi.org/10.7150/thno.46417
Autor:
Jong Soon Kang, Gyoonhee Han, Sunghoon Kim, Kilsoo Jung, Chul-Ho Lee, Seung Joon Park, Jae Hyun Kim, Kibum Kim, Jung Min Han, Hee Chan Yoo, Kyeong Lee, Doona Song
Publikováno v:
Bioorganic chemistry. 112
The enzyme leucyl-tRNA synthetase (LRS) and the amino acid leucine regulate the mechanistic target of rapamycin (mTOR) signaling pathway. Leucine-dependent mTORC1 activation depends on GTPase activating protein events mediated by LRS. In a prior stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f1dd32e213e5934dca7085b856fc5f
https://pubmed.ncbi.nlm.nih.gov/33979735
https://pubmed.ncbi.nlm.nih.gov/33979735
Autor:
Ho Jeong Kwon, Ju Yeon Lee, Jong Shin Yoo, Jin Young Kim, Charlotte Welinder, Tae Young Kim, Melinda Rezeli, Roger Appelqvist, György Marko-Varga, Yonghyo Kim, Doona Song, Sung Min Cho, Gyoonhee Han, Yutaka Sugihara
Publikováno v:
Biomolecules
Biomolecules, Vol 10, Iss 508, p 508 (2020)
Volume 10
Issue 4
Biomolecules, Vol 10, Iss 508, p 508 (2020)
Volume 10
Issue 4
Although natural products are an important source of drugs and drug leads, identification and validation of their target proteins have proven difficult. Here, we report the development of a systematic strategy for target identification and validation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3386077bc43b3b284717eee18cbbfd7
https://doi.org/10.20944/preprints202002.0009.v1
https://doi.org/10.20944/preprints202002.0009.v1
Autor:
Jee Sun, Yang, Doona, Song, Won Jin, Ko, Bunyea, Kim, Bo-Kyung, Kim, Song-Kyu, Park, Misun, Won, Kiho, Lee, Kyeong, Lee, Hwan Mook, Kim, Gyoonhee, Han
Publikováno v:
European Journal of Medicinal Chemistry. 63:621-628
A series of novel aliphatic amido-quaternary ammonium salts were synthesized and evaluated for their anticancer effects involving induction of RhoB. Most of these compounds, featuring open-ring forms of aliphatic amido-quaternary ammonium salts, exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b42eec144a99c898469f84c99098bb
https://doi.org/10.1016/j.ejmech.2012.12.063
https://doi.org/10.1016/j.ejmech.2012.12.063