Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Doo-Soon Im"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The mammalian brain, especially the cerebral cortex, has evolved to increase in size and complexity. The proper development of the cerebral cortex requires the coordination of several events, such as differentiation and migration, that are essential
Externí odkaz:
https://doaj.org/article/ced0ebe7e3ab40b291e32e07efcbf133
Autor:
Doo Soon Im, Alvin Joselin, Devon Svoboda, Tesuya Takano, Maxime W. C. Rousseaux, Steve Callaghan, Ruth S. Slack, Shin-ichi Hisanaga, Roger J. Davis, David S. Park, Dianbo Qu
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background Activated Cdk5 regulates a number of processes during nervous system formation, including neuronal differentiation, growth cone stabilization, and axonal growth. Cdk5 phosphorylates its downstream substrates located in axonal grow
Externí odkaz:
https://doaj.org/article/96f63e0ea73a4bf79a28c2d3433be87b
The evolution of the mammalian brain, particularly the cerebral cortex, is characterized by an increase in size and complexity. Proper development of the cerebral cortex involves several coordinated events such as differentiation and migration, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c927bd2196cea426c1aea2d22a8344e4
https://doi.org/10.21203/rs.3.rs-2921296/v1
https://doi.org/10.21203/rs.3.rs-2921296/v1
Autor:
Qiubo Jiang, Brian O'Nuallain, Clemens R. Scherzer, Eve C. Tsai, Jennifer A. Chan, Peggy Taylor, John Woulfe, An Tran, Ming Jin, Steve M. Callaghan, Gary S. Shaw, Masashi Takanashi, Bojan Shutinoski, Mei Zhang, Jacqueline M. Tokarew, Jasmine M. Khan, Nobutaka Hattori, Daniel N. El-Kodsi, Luigi Zecca, Alexandre Prat, Andrew B. West, Andy C. H. Ng, Xiajun Dong, Juan Li, Travis K. Fehr, Liqun Wang, Nathalie A. Lengacher, Angela P. Nguyen, David S. Park, Doo Soon Im, Julianna J. Tomlinson, Gergely Tóth, Michael G. Schlossmacher, Kathryn R. Barber, Lawrence G. Puente, Arne Holmgren, Stephanie Zandee, Rajib Sengupta
Publikováno v:
Acta Neuropathologica
The mechanisms by which parkin protects the adult human brain from Parkinson disease remain incompletely understood. We hypothesized that parkin cysteines participate in redox reactions and that these are reflected in its posttranslational modificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8c45df270412089e53128defbb6048
http://europepmc.org/articles/PMC8043881
http://europepmc.org/articles/PMC8043881
Autor:
Keoung Sun Son, Eun-Hye Joe, Bok-Nam Park, Young-Sil An, Doo Soon Im, Bok Seon Yoon, Kyung Eon Lee, Dong Hoon Hwang, Chan Bae Park, Jin Soo Lee, Jiman Hong, Byung Gon Kim
Publikováno v:
Experimental Neurobiology
Many previous studies have shown reduced glucose uptake in the ischemic brain. In contrast, in a permanent unilateral common carotid artery occlusion (UCCAO) mouse model, our pilot experiments using 18F-fluorodeoxyglucose positron emission tomography
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c63d3aa75c615768d3d24fef5b1f939
http://europepmc.org/articles/PMC7075656
http://europepmc.org/articles/PMC7075656
Autor:
Doo Soon Im, Alvin Joselin, Devon Svoboda, Tesuya Takano, Maxime W. C. Rousseaux, Steve Callaghan, Ruth S. Slack, Shin-ichi Hisanaga, Roger J. Davis, David S. Park, Dianbo Qu
Publikováno v:
BMC biology. 20(1)
Background Activated Cdk5 regulates a number of processes during nervous system formation, including neuronal differentiation, growth cone stabilization, and axonal growth. Cdk5 phosphorylates its downstream substrates located in axonal growth cones,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eba957ac64ed06360932bbefffe4675
https://pubmed.ncbi.nlm.nih.gov/35581583
https://pubmed.ncbi.nlm.nih.gov/35581583
Autor:
Luigi Zecca, Juan Li, Travis K. Fehr, Qiubo Jiang, Nobutaka Hattori, Jennifer A. Chan, Masashi Takanashi, Rajib Sengupta, Chantal A. Pileggi, Lawrence G. Puente, Matthew J. LaVoie, Angela P. Nguyen, David S. Park, Arne Holmgren, Andy C. H. Ng, Nathalie A. Lengacher, Steve M. Callaghan, Doo Soon Im, Boston H, Julianna J. Tomlinson, Bojan Shutinoski, Michael G. Schlossmacher, El Kodsi Dn, Gary S. Shaw, Rajiv R. Ratan, Mary-Ellen Harper, Jacqueline M. Tokarew, Palmberg C
SUMMARYWe recently hypothesized that parkin plays a role in redox homeostasis and provided evidence that it directly reduces hydrogen peroxide (H2O2) in vitro. Here, we examined this anti-oxidant activity in vivo. Informed by findings in human brain,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67dd553d778023f7b7801aa9abc0771
Autor:
Matthew J. During, Wassamon Boonying, Doo Soon Im, Steve M. Callaghan, Grace O. Iyirhiaro, Ruth S. Slack, David S. Park
Publikováno v:
The Journal of Neuroscience. 37:6729-6740
Dysregulation of cell cycle machinery is implicated in a number of neuronal death contexts, including stroke. Increasing evidence suggests that cyclin-dependent kinases (Cdks) are inappropriately activated in mature neurons under ischemic stress cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2e32b9786da805c34475d13c5251e66
https://doi.org/10.1523/jneurosci.3017-16.2017
https://doi.org/10.1523/jneurosci.3017-16.2017
Autor:
Steve M. Callaghan, Wassamon Boonying, Lisa M. Julian, Ruth S. Slack, Yasmilde Rodriguez Gonzalez, Alvin Joselin, David S. Park, Tianwen Huang, Sally L. Dunwoodie, Farzaneh Safarpour, Doo Soon Im, Dianbo Qu, Eugene Wang, En Huang
Publikováno v:
J Biol Chem
We previously reported that the cell cycle–related cyclin-dependent kinase 4–retinoblastoma (RB) transcriptional corepressor pathway is essential for stroke-induced cell death both in vitro and in vivo. However, how this signaling pathway induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d0afc363523d38f3af47673ee62dc7
https://pubmed.ncbi.nlm.nih.gov/30967472
https://pubmed.ncbi.nlm.nih.gov/30967472
Autor:
Eun Hye Joe, Sangwook Park, Ilo Jou, Young Ho Suh, Ji Hee Choi, Jung Sub Park, Sang Myun Park, Sung Soo Jang, Doo Soon Im
Publikováno v:
NeuroReport. 25:18-22
For many years, brain ischemia has been known to be a leading cause of adult neurological disorder. In particular, many reports have shown that hyperexcitability of neurons and inflammatory response of the glia induced by ischemic reperfusion (I/R) d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c49e8b1b7657c6376b56816f29e6c6
https://doi.org/10.1097/wnr.0000000000000022
https://doi.org/10.1097/wnr.0000000000000022