Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Donya Pakravan"'
Autor:
Joris Van Lindt, Tamas Lazar, Donya Pakravan, Manon Demulder, Attila Meszaros, Ludo Van Den Bosch, Dominique Maes, Peter Tompa
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 622-635 (2022)
Heterogeneous nuclear ribonucleoproteins (hnRNP) function in RNA processing, have RNA-recognition motifs (RRMs) and intrinsically disordered, low-complexity domains (LCDs). While RRMs are drivers of RNA binding, there is only limited knowledge about
Externí odkaz:
https://doaj.org/article/7ce62ebd8d58433f837a08885965a272
Autor:
Joris Van Lindt, Anna Bratek-Skicki, Phuong N. Nguyen, Donya Pakravan, Luis F. Durán-Armenta, Agnes Tantos, Rita Pancsa, Ludo Van Den Bosch, Dominique Maes, Peter Tompa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Van Lindt, Bratek-Skicki et al. show that at carefully selected pH values, proteins can be kept in solution and their LLPS can then be induced by a jump to native pH. This presents a generic method to study the full kinetic trajectory of LLPS under n
Externí odkaz:
https://doaj.org/article/b7ebf01cce4d42dd989460bcbd0ea84b
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). However, the exact pathogenic mechanism of mutant fused in sarcoma (FUS) protein is not completely understood. FUS is an RNA binding protein (RBP) localized predominantly in the
Externí odkaz:
https://doaj.org/article/ebd1888ca0c1479fb3d0de65b6a59402
Autor:
Donya Pakravan, Emiel Michiels, Anna Bratek-Skicki, Mathias De Decker, Joris Van Lindt, David Alsteens, Sylvie Derclaye, Philip Van Damme, Joost Schymkowitz, Frederic Rousseau, Peter Tompa, Ludo Van Den Bosch
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 548 (2021)
Aggregates of TAR DNA-binding protein (TDP-43) are a hallmark of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Although TDP-43 aggregates are an undisputed pathological species at the end stage of these diseases,
Externí odkaz:
https://doaj.org/article/677074b6e75743c6857c7198627b5b74
Autor:
Joris Van Lindt, Anna Bratek-Skicki, Phuong N. Nguyen, Donya Pakravan, Luis F. Durán-Armenta, Agnes Tantos, Rita Pancsa, Ludo Van Den Bosch, Dominique Maes, Peter Tompa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-01853-4.
Externí odkaz:
https://doaj.org/article/d19b668ccaf348b4b1dce157fe825693
Publikováno v:
Journal of Molecular Cell Biology
Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disease selectively affecting motor neurons, leading to progressive paralysis. Although most cases are sporadic, ∼10% are familial. Similar proteins are found in aggregates in sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd0f643155c425c26985209ad2f9cd9
http://europepmc.org/articles/PMC8036000
http://europepmc.org/articles/PMC8036000
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). However, the exact pathogenic mechanism of mutant fused in sarcoma (FUS) protein is not completely understood. FUS is an RNA binding protein (RBP) localized predominantly in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127d4b5820589e6dfe1a9de93daea5c3
https://lirias.kuleuven.be/handle/123456789/682763
https://lirias.kuleuven.be/handle/123456789/682763
Autor:
Frederic Rousseau, Emiel Michiels, Anna Bratek-Skicki, Joost Schymkowitz, Ludo Van Den Bosch, Donya Pakravan, Yves Moreau, Gabriele Orlando, Daniele Raimondi
Motivation Proteins able to undergo liquid–liquid phase separation (LLPS) in vivo and in vitro are drawing a lot of interest, due to their functional relevance for cell life. Nevertheless, the proteome-scale experimental screening of these proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7641dcbf50d6d9da363a0983b4b9a45a
https://lirias.kuleuven.be/handle/123456789/675521
https://lirias.kuleuven.be/handle/123456789/675521
Autor:
Ludo Van Den Bosch, Frederic Rousseau, Emiel Michiels, Mathias De Decker, Peter Tompa, Sylvie Derclaye, Anna Bratek-Skicki, Philip Van Damme, David Alsteens, Joris Van Lindt, Donya Pakravan, Joost Schymkowitz
Publikováno v:
Biomolecules
Volume 11
Issue 4
Biomolecules, Vol. 11, no.4, p. 548 (2021)
Biomolecules, Vol 11, Iss 548, p 548 (2021)
Volume 11
Issue 4
Biomolecules, Vol. 11, no.4, p. 548 (2021)
Biomolecules, Vol 11, Iss 548, p 548 (2021)
Aggregates of TAR DNA-binding protein (TDP-43) are a hallmark of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Although TDP-43 aggregates are an undisputed pathological species at the end stage of these diseases,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd311aaacf6359f17dd6ba426b23cd54
Autor:
Matthieu Moisse, Philip Van Damme, Laura Fumagalli, Jimmy Beckers, Bart Swinnen, Mathias De Decker, Donya Pakravan, Thomas Vercruysse, Catherine M. Verfaillie, Tijs Vandoorne, Wenting Guo, Kristel Eggermont, Pieter Vanden Berghe, Raheem Fazal, Ruben Boon, Ludo Van Den Bosch, Joni Vanneste, Steven Boeynaems, Ann Swijsen
Publikováno v:
The EMBO Journal
TDP‐43 is the major component of pathological inclusions in most ALS patients and in up to 50% of patients with frontotemporal dementia (FTD). Heterozygous missense mutations in TARDBP, the gene encoding TDP‐43, are one of the common causes of fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2efbe7a668b7996e56e9aa7a2da707
https://doi.org/10.15252/embj.2020106177
https://doi.org/10.15252/embj.2020106177