Výsledky vyhledávání - "Donovan Y.Z. Phua"

Mechanosensing through direct binding of tensed F-actin by LIM domains

Autor: Clare M. Waterman, Rui Gong, Lucas Axiotakis, Santiago Reyes, Xiaoyu Sun, Mark A. Smith, Donovan Y.Z. Phua, Robert C. Cail, Mary C. Beckerle, Elizabeth Blankman, Gregory M. Alushin

Publikováno v: Dev Cell

SummaryMechanical signals transmitted through the cytoplasmic actin cytoskeleton must be relayed to the nucleus to control gene expression. LIM domains are protein-protein interaction modules found in cytoskeletal proteins and transcriptional regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f333de7d841b93f6f36a14b2837756e
https://doi.org/10.1101/2020.03.06.979245

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Distinct Mechanisms of Resistance to a CENP-E Inhibitor Emerge in Near-Haploid and Diploid Cancer Cells

Autor: Tarun M. Kapoor, Donovan Y.Z. Phua, Rudolf Pisa

Publikováno v: Cell Chem Biol

Aberrant chromosome numbers in cancer cells may impose distinct constraints on the emergence of drug resistance-a major factor limiting the long-term efficacy of molecularly targeted therapeutics. However, for most anticancer drugs we lack analyses o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096338421f0e5bf2cd6b61c27776800d
https://doi.org/10.1016/j.chembiol.2020.05.003

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