Výsledky vyhledávání - "Donovan Trinidad"

Akademický článek

DIMPLE: deep insertion, deletion, and missense mutation libraries for exploring protein variation in evolution, disease, and biology

Autor: Christian B. Macdonald, David Nedrud, Patrick Rockefeller Grimes, Donovan Trinidad, James S. Fraser, Willow Coyote-Maestas

Publikováno v: Genome Biology, Vol 24, Iss 1, Pp 1-19 (2023)

Abstract Insertions and deletions (indels) enable evolution and cause disease. Due to technical challenges, indels are left out of most mutational scans, limiting our understanding of them in disease, biology, and evolution. We develop a low cost and

Externí odkaz: https://doaj.org/article/11399c52db2f4426b21268f10cf7d139

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Deep Insertion, Deletion, and Missense Mutation Libraries for Exploring Protein Variation in Evolution, Disease, and Biology

Autor: Christian B. Macdonald, David Nedrud, Patrick Rockefeller Grimes, Donovan Trinidad, James S. Fraser, Willow Coyote-Maestas

Insertions and deletions (indels) are a major source of genetic variation in evolution and the cause of nearly 30% of Mendelian disease. Despite their importance, indels are left out of nearly every systematic mutational scan to date due to technical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0d3c1051ed8660ce8b15749b799d8a4
https://doi.org/10.1101/2022.07.26.501589

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