Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Donogh J. R. O'Mahony"'
Autor:
Fabien Vincent, Michelle Dourado, Daniel Emerling, Luna Liu, Victor Yip, Margaret Nguyen, Zhi-Liang Wei, Zipfel Sheila, Candace Chi, Amy Gustafson, Jeff DeFalco, Michael G. Kelly, John Kincaid, Qingling Zhang, Donogh J R O'Mahony, Matthew A.J. Duncton, Alejandra Acevedo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4011-4015
Antagonists of the TRPV4 receptor were identified using a focused screen, followed by a limited optimization program. The leading compounds obtained from this exercise, RN-1665 23 and RN-9893 26, showed moderate oral bioavailability when dosed to rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53256b218e4196c4d5f87c151a03f04
https://doi.org/10.1016/j.bmcl.2015.06.098
https://doi.org/10.1016/j.bmcl.2015.06.098
Autor:
Ashley Houchin, Donogh J R O'Mahony, Chris Celeri, Ramin Najafi, Eddy Low, Timothy P. Shiau, Rakesh K. Jain, Ping Xu, Bum Tae Kim, Charles Francavilla, Mark B. Anderson, Meghan Zuck, Nichole J Alvarez, Eric Douglas Turtle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3682-3685
Structure stability/activity relationships (SXR) of a new class of N,N-dichloroamine compounds were explored to improve antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans while maintaining aqueous solution st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e623ed81938624b45311b013b638f0a8
https://doi.org/10.1016/j.bmcl.2011.04.084
https://doi.org/10.1016/j.bmcl.2011.04.084
Autor:
Donogh J R O'Mahony, Matthew Cox, William T. Edwards, Matthew A.J. Duncton, Kiran P. Sahasrabudhe, Darlene Tan, Zipfel Sheila, M. Angels Estiarte
Publikováno v:
Journal of Heterocyclic Chemistry. 46:1125-1131
A one-step synthesis of thiazolo[5,4-b]pyridines from an appropriately substituted chloronitropyridine and thioamide, or thiourea, is presented. In particular, the reaction was used to prepare a large number of 6-nitrothiazolo[5,4-b]pyridine derivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccd89f6f03902d5a13e340313e13f25c
https://doi.org/10.1002/jhet.185
https://doi.org/10.1002/jhet.185
Autor:
William T. Edwards, Donogh J. R. O'Mahony, Michael G. Kelly, Matthew Duncton, Matthew Cox, M. Angels Estiarte, Russell J. Johnson
Publikováno v:
The Journal of Organic Chemistry. 74:6354-6357
Introduction of oxetan-3-yl and azetidin-3-yl groups into heteroaromatic bases was achieved by using a radical addition method (Minisci reaction). To demonstrate utility, the process was used to introduce an oxetane or azetidine into heteroaromatic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc4680741a3ed09208b94a566c12dd6
https://doi.org/10.1021/jo9010624
https://doi.org/10.1021/jo9010624
Autor:
Donogh J R O'Mahony, Matthew A.J. Duncton, John Kincaid, Darlene Tan, Michael G. Kelly, M. Angels Estiarte, William T. Edwards, Russell J. Johnson, Min Wan, Carl Kaub, Matthew Cox
Publikováno v:
Organic Letters. 10:3259-3262
The oxetan-3-yl and azetidin-3-yl substituents have previously been identified as privileged motifs within medicinal chemistry. An efficient approach to installing these two modules into aromatic systems, using a nickel-mediated alkyl-aryl Suzuki cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9be423485cb5d658858b2158f01046b
https://doi.org/10.1021/ol8011327
https://doi.org/10.1021/ol8011327
Publikováno v:
Synthesis. 2000:1009-1019
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24989e21a7a6b35bd22726cfd83b921f
https://doi.org/10.1055/s-2000-6301
https://doi.org/10.1055/s-2000-6301
Publikováno v:
Tetrahedron Letters. 39:7637-7640
Heat alone has been found sufficient to promote intramolecular Pauson-Khand cyclizations catalyzed by high purity Co 2 (CO) 8 . The existence of a very narrow thermal window (e.g., 60 °C – 70 °C) for the attainment of efficient catalysis is a not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb467811fb9cf55b4071656b8fbacaf
https://doi.org/10.1016/s0040-4039(98)01693-1
https://doi.org/10.1016/s0040-4039(98)01693-1
Autor:
Louisa D'Lima, Timothy P. Shiau, Ramin Najafi, Mark L Anderson, Meghan Zuck, Rakesh K. Jain, Andreas Jekle, Dmitri Debabov, Eddy Low, Charles Francavilla, Eric Douglas Turtle, Bum Tae Kim, Lisa Friedman, Nichole J Alvarez, Donogh J R O'Mahony
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(20)
The discovery and development of antimicrobial agents that do not give rise to resistance remains an ongoing challenge. Our efforts in this regard continue to reveal new potential therapeutic agents with differing physicochemical properties while ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69fff1f82a257c236caf088a6e47042
https://pubmed.ncbi.nlm.nih.gov/23999044
https://pubmed.ncbi.nlm.nih.gov/23999044
Publikováno v:
ChemInform. 44
Title compounds (III), (V), (VII) and (IX) are prepared via a three-step/one-pot pyridine-annulation strategy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::128733f6bd69c22a861ba44d6d0356e3
https://doi.org/10.1002/chin.201328148
https://doi.org/10.1002/chin.201328148
Autor:
Ramin Najafi, Timothy P. Shiau, Mark B. Anderson, Meghan Zuck, Lisa C Friedman, Eddy Low, Eric Douglas Turtle, Nichole J Alvarez, Donogh J R O'Mahony, Rakesh K. Jain, Charles Francavilla
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(10)
Antimicrobial resistance against many known therapeutics is on the rise. We examined derivatives of 3-chlorooxazolidin-2-one 1a (X=H) as antibacterial and antifungal agents. The key findings were that the activity and apparent in vitro cytotoxicity c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4ec97203a656fe7860b4c65cf3c53e
https://pubmed.ncbi.nlm.nih.gov/21470861
https://pubmed.ncbi.nlm.nih.gov/21470861