Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Donny Wong"'
Publikováno v:
Respirology Case Reports, Vol 11, Iss 9, Pp n/a-n/a (2023)
Abstract Alteplase as a fibrinolytic can be used to break up fibrin to encourage clot breakdown for clinical use. In the pleural space, it is used for symptomatic loculated malignant pleural effusions and pleural infections and can potentially avoid
Externí odkaz:
https://doaj.org/article/e1878ac4d2cf40be98ae04a823da2572
Autor:
Nick A Maskell, Anthony Edey, Oliver J Bintcliffe, Y.C.G. Lee, Francesco Piccolo, Donny Wong, Natalia Popowicz
Publikováno v:
Respirology. 21:57-59
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::546ef506d2b2db4bb70680be4749d3cc
https://doi.org/10.1111/resp.12754_15
https://doi.org/10.1111/resp.12754_15
Autor:
Donny Wong, Bruce Demple
Publikováno v:
Journal of Biological Chemistry. 279:25268-25275
The Ape1 protein initiates the repair of apurinic/apyrimidinic sites during mammalian base excision repair (BER) of DNA. Ape1 catalyzes hydrolysis of the 5'-phosphodiester bond of abasic DNA to create nicks flanked by 3'-hydroxyl and 5'-deoxyribose 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc16f7fade752fdd064b09bdb032e27
https://doi.org/10.1074/jbc.m400804200
https://doi.org/10.1074/jbc.m400804200
Publikováno v:
Journal of Biological Chemistry. 278:36242-36249
The major abasic endonuclease of human cells, Ape1 protein, is a multifunctional enzyme with critical roles in base excision repair (BER) of DNA. In addition to its primary activity as an apurinic/apyrimidinic endonuclease in BER, Ape1 also possesses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06acd39cfeeca25785728f1b92139021
https://doi.org/10.1074/jbc.m306065200
https://doi.org/10.1074/jbc.m306065200
Autor:
Ju-Huei Chiang, Wendy M. Clendenin, Bruce Demple, Donny Wong, Malgorzata M. Slupska, Jeffrey H Miller, Hanjing Yang
Publikováno v:
Nucleic Acids Research. 29:743-752
Adenine-DNA glycosylase MutY of Escherichia coli catalyzes the cleavage of adenine when mismatched with 7,8-dihydro-8-oxoguanine (GO), an oxidatively damaged base. The biological outcome is the prevention of C/G→A/T transversions. The molecular mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8e1974610b4afa3c9618da58f9704c
https://doi.org/10.1093/nar/29.3.743
https://doi.org/10.1093/nar/29.3.743
Publikováno v:
Nature Reviews Drug Discovery. 11:669-670
In the wake of the recent approvals of the first new obesity therapies in more than a decade, Wong and colleagues analyse their market prospects as well as the late-stage pipeline.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a80bb5aa51530347fa9486a808bd97b3
https://doi.org/10.1038/nrd3830
https://doi.org/10.1038/nrd3830
Autor:
Donny Wong, Michael S. DeMott, Brian C. Bales, Bruce Demple, Ergin Beyret, Jae Taeg Hwang, Marc M. Greenberg
Publikováno v:
The Journal of biological chemistry. 277(10)
Oxidized abasic residues in DNA constitute a major class of radiation and oxidative damage. Free radical attack on the nucleotidyl C-1′ carbon yields 2-deoxyribonolactone (dL) as a significant lesion. Although dL residues are efficiently incised by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023caf9115676f93ba33f0c5992e9a78
https://pubmed.ncbi.nlm.nih.gov/11805079
https://pubmed.ncbi.nlm.nih.gov/11805079
Publikováno v:
Advances in DNA Damage and Repair ISBN: 9781461372073
Abasic sites arise in DNA by many routes, including the excision of modified bases and direct attack by free radicals. The key enzymes in repair of these sites are AP endonucleases, which can incise abasic residues or remove abasic deoxyribose fragme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f78527c70f87232334d735eaac826f7
https://doi.org/10.1007/978-1-4615-4865-2_6
https://doi.org/10.1007/978-1-4615-4865-2_6
Mutagenic abasic (AP) sites are generated directly by DNA-damaging agents or by DNA glycosylases acting in base excision repair. AP sites are corrected via incision by AP endonucleases, removal of deoxyribose 5-phosphate, repair synthesis, and ligati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65337ad5770a6446f5132c72b6971de
https://europepmc.org/articles/PMC23779/
https://europepmc.org/articles/PMC23779/
Publikováno v:
Plant molecular biology. 28(6)
The coding sequence for FLP recombinase, originally from the 2 mu plasmid of Saccharomyces cerevisiae, was introduced into Arabidopsis behind the cauliflower mosaic virus 35S promoter. FLP activity was monitored by the glucuronidase activity resultin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc1586663f90e99abf3a97915933c3a
https://pubmed.ncbi.nlm.nih.gov/7548830
https://pubmed.ncbi.nlm.nih.gov/7548830