Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Donny D Licatalosi"'
Autor:
Mohammed R Alzahrani, Bo-Jhih Guan, Leah L Zagore, Jing Wu, Chien-Wen Chen, Donny D Licatalosi, Kristian E Baker, Maria Hatzoglou
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0271695 (2022)
Endoplasmic Reticulum (ER) stress, caused by the accumulation of misfolded proteins in the ER, elicits a homeostatic mechanism known as the Unfolded Protein Response (UPR). The UPR reprograms gene expression to promote adaptation to chronic ER stress
Externí odkaz:
https://doaj.org/article/d366124372274fe29bdaafd94e7ed8ac
Publikováno v:
Cell Reports, Vol 19, Iss 12, Pp 2598-2612 (2017)
Summary: Alternative splicing has essential roles in development. Remarkably, spermatogenic cells express more alternatively spliced RNAs compared to most whole tissues; however, regulation of these RNAs remains unclear. Here, we characterize the alt
Externí odkaz:
https://doaj.org/article/9be5f538bbf84ebd80e46194f28609ea
Autor:
Peng Yu, Steven T. Sizemore, Ruth A. Keri, Kristen L. Weber-Bonk, Darcie D. Seachrist, Vinay Varadan, Bryan M. Webb, Gurkan Bebek, Molly M. Hannigan, Natasha N. Ingles, Salendra Singh, Donny D. Licatalosi
Publikováno v:
J Biol Chem
The phenotypes of each breast cancer subtype are defined by their transcriptomes. However, the transcription factors that regulate differential patterns of gene expression that contribute to specific disease outcomes are not well understood. Here, us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d27ea8dcd4920dd5e1b08ade8751e7
https://doi.org/10.1074/jbc.ra120.014018
https://doi.org/10.1074/jbc.ra120.014018
Autor:
Mohammed R. Alzahrani, Bo-Jhih Guan, Leah L. Zagore, Jing Wu, Donny D. Licatalosi, Kristian E. Baker, Maria Hatzoglou
Endoplasmic Reticulum (ER) stress, caused by the accumulation of misfolded proteins in the ER, elicits a homeostatic mechanism known as the Unfolded Protein Response (UPR). The UPR reprograms gene expression to promote adaptation to chronic ER stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c77197b5e60def7e03409d560c24e16
https://doi.org/10.1101/2022.03.06.483204
https://doi.org/10.1101/2022.03.06.483204
Autor:
Donny D. Licatalosi
Publikováno v:
Molecular Cell. 81:2275-2277
Wan et al. (2021) establish a powerful new platform to measure the dynamics of transcription and splicing of endogenous genes in single cells in real time. Combining real-time measurements with multiple deep-sequencing tools reveals an unexpectedly h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4a7798e834b853c404d20fa2cff069c
https://doi.org/10.1016/j.molcel.2021.05.019
https://doi.org/10.1016/j.molcel.2021.05.019
Publikováno v:
Trends in Biochemical Sciences. 46:861-862
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2346085f86a79c860a8148c5b7a7a1bc
https://doi.org/10.1016/j.tibs.2021.07.006
https://doi.org/10.1016/j.tibs.2021.07.006
Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress
Autor:
Yuanhui Mao, Dawid Krokowski, Erica Shu, Di Hu, Raul Jobava, Eckhard Jankowsky, Evelyn Chukwurah, Leah L. Zagore, Xin Qi, Youwei Zhang, Shu-Bing Qian, Ivan Topisirovic, Zhaofeng Gao, Donny D. Licatalosi, Bo-Jhih Guan, William C. Merrick, Maria Hatzoglou, Jing Wu
SummaryMammalian cells have to adapt to environmental challenges that range from mild to severe stress. While the cellular response to mild stress has been widely studied, how cells respond to severe stress remains unclear. We show here that under se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02576d50ca6841d07d773357c0d278c4
https://doi.org/10.1101/2020.10.10.334375
https://doi.org/10.1101/2020.10.10.334375
Autor:
Leah L. Zagore, Deepak Sharma, Xuan Ye, Eckhard Jankowsky, Carlos E Crespo-Hern aacutendez, Matthew M. Brister, Donny D. Licatalosi
Publikováno v:
Nature
Gene expression in higher eukaryotic cells orchestrates interactions between thousands of RNA binding proteins (RBPs) and tens of thousands of RNAs1. The kinetics by which RBPs bind to and dissociate from their RNA sites are critical for the coordina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f46b1054fef8fdc81c6ea2d7b39042
https://pubmed.ncbi.nlm.nih.gov/33828270
https://pubmed.ncbi.nlm.nih.gov/33828270
Publikováno v:
Quantitative Biology. 6:228-238
BACKGROUND: Our understanding of post-transcriptional gene regulation has increased exponentially with the development of robust methods to define protein-RNA interactions across the transcriptome. In this review, we highlight the evolution and succe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba292b12db58972c380d741fb01aeeb2
https://doi.org/10.1007/s40484-018-0145-6
https://doi.org/10.1007/s40484-018-0145-6
Autor:
Jodi L. Bubenik, Xing Chen, Donny D. Licatalosi, Kommireddy Vasu, Hui Yang, Tomasz Herjan, Xiao Li, Caini Liu, Xiaoxia Li, Katarzyna Bulek, Wen Qian, Suidong Ouyang, Jun Qin, Kewal Asosingh, Paul L. Fox, Lingzi Hong, Eric Cockman, Thomas A. Hamilton, Junjie Zhao, Mark A. Aronica, Donna M. Driscoll, Hao Zhou
Publikováno v:
Nature Immunology. 19:354-365
Mechanisms that degrade inflammatory mRNAs are well known; however, stabilizing mechanisms are poorly understood. Here, we show that Act1, an interleukin-17 (IL-17)-receptor-complex adaptor, binds and stabilizes mRNAs encoding key inflammatory protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81484e9fc28ab431cf348c253cf64a6d
https://doi.org/10.1038/s41590-018-0071-9
https://doi.org/10.1038/s41590-018-0071-9