Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Donnie S Stapleton"'
Autor:
Christopher H Emfinger, Lauren E Clark, Brian Yandell, Kathryn L Schueler, Shane P Simonett, Donnie S Stapleton, Kelly A Mitok, Matthew J Merrins, Mark P Keller, Alan D Attie
Publikováno v:
eLife, Vol 12 (2023)
Insufficient insulin secretion to meet metabolic demand results in diabetes. The intracellular flux of Ca2+ into β-cells triggers insulin release. Since genetics strongly influences variation in islet secretory responses, we surveyed islet Ca2+ dyna
Externí odkaz:
https://doaj.org/article/de0ff10cf88640b2b8b46a53e15528a6
Autor:
Tara R Price, Donnie S Stapleton, Kathryn L Schueler, Marie K Norris, Brian W Parks, Brian S Yandell, Gary A Churchill, William L Holland, Mark P Keller, Alan D Attie
Publikováno v:
PLoS Genetics, Vol 19, Iss 7, p e1010713 (2023)
We and others have previously shown that genetic association can be used to make causal connections between gene loci and small molecules measured by mass spectrometry in the bloodstream and in tissues. We identified a locus on mouse chromosome 7 whe
Externí odkaz:
https://doaj.org/article/754e612d4ef044c484fffca47c26b6ac
Autor:
Mark P Keller, Pradyut K Paul, Mary E Rabaglia, Donnie S Stapleton, Kathryn L Schueler, Aimee Teo Broman, Shuyun Isabella Ye, Ning Leng, Christopher J Brandon, Elias Chaibub Neto, Christopher L Plaisier, Shane P Simonett, Melkam A Kebede, Gloria M Sheynkman, Mark A Klein, Nitin S Baliga, Lloyd M Smith, Karl W Broman, Brian S Yandell, Christina Kendziorski, Alan D Attie
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006466 (2016)
Human genome-wide association studies (GWAS) have shown that genetic variation at >130 gene loci is associated with type 2 diabetes (T2D). We asked if the expression of the candidate T2D-associated genes within these loci is regulated by a common loc
Externí odkaz:
https://doaj.org/article/a7a38973596a4970afaa372927d78706
Autor:
Hong Lan, Meng Chen, Jessica B Flowers, Brian S Yandell, Donnie S Stapleton, Christine M Mata, Eric Ton-Keen Mui, Matthew T Flowers, Kathryn L Schueler, Kenneth F Manly, Robert W Williams, Christina Kendziorski, Alan D Attie
Publikováno v:
PLoS Genetics, Vol 2, Iss 1, p e6 (2006)
Coordinated regulation of gene expression levels across a series of experimental conditions provides valuable information about the functions of correlated transcripts. The consideration of gene expression correlation over a time or tissue dimension
Externí odkaz:
https://doaj.org/article/83ed0c24204d4bbdb00963d7bf630d7b
Autor:
Chenyang Dong, Shane P. Simonett, Sunyoung Shin, Donnie S. Stapleton, Kathryn L. Schueler, Gary A. Churchill, Leina Lu, Xiaoxiao Liu, Fulai Jin, Yan Li, Alan D. Attie, Mark P. Keller, Sündüz Keleş
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-32 (2021)
Abstract Genome-wide association studies reveal many non-coding variants associated with complex traits. However, model organism studies largely remain as an untapped resource for unveiling the effector genes of non-coding variants. We develop INFIMA
Externí odkaz:
https://doaj.org/article/47ca5af6b89a420aa3de1a894239c486
Autor:
Christopher H. Emfinger, Eleonora de Klerk, Kathryn L. Schueler, Mary E. Rabaglia, Donnie S. Stapleton, Shane P. Simonett, Kelly A. Mitok, Ziyue Wang, Xinyue Liu, Joao A. Paulo, Qinq Yu, Rebecca L. Cardone, Hannah R. Foster, Sophie L. Lewandowski, José C. Perales, Christina M. Kendziorski, Steven P. Gygi, Richard G. Kibbey, Mark P. Keller, Matthias Hebrok, Matthew J. Merrins, Alan D. Attie
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Insulin secretion from pancreatic β cells is essential for glucose homeostasis. An insufficient response to the demand for insulin results in diabetes. We previously showed that β cell–specific deletion of Zfp148 (β-Zfp148KO) improves glucose to
Externí odkaz:
https://doaj.org/article/89940b8a0be241239ae78674f9a31df7
Autor:
Rita C. Andersen, Jan H. Schmidt, Joscha Rombach, Matthew D. Lycas, Nikolaj R. Christensen, Viktor K. Lund, Donnie S. Stapleton, Signe S. Pedersen, Mathias A. Olsen, Mikkel Stoklund, Gith Noes-Holt, Tommas T.E. Nielsen, Mark P. Keller, Anna M. Jansen, Rasmus Herlo, Massimo Pietropaolo, Jens B. Simonsen, Ole Kjærulff, Birgitte Holst, Alan D. Attie, Ulrik Gether, Kenneth L. Madsen
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
Bin/amphiphysin/Rvs (BAR) domains are positively charged crescent-shaped modules that mediate curvature of negatively charged lipid membranes during remodeling processes. The BAR domain proteins PICK1, ICA69, and the arfaptins have recently been demo
Externí odkaz:
https://doaj.org/article/283f087eadbe4c509ab194ae13855604
Autor:
Jee-Hwan Oh, Kathryn L. Schueler, Donnie S. Stapleton, Laura M. Alexander, Chi-Liang Eric Yen, Mark P. Keller, Alan D. Attie, Jan-Peter van Pijkeren
Publikováno v:
mSphere, Vol 5, Iss 3 (2020)
ABSTRACT The incidence of metabolic syndrome continues to rise globally. In mice, intravenous administration of interleukin-22 (IL-22) ameliorates various disease phenotypes associated with diet-induced metabolic syndrome. In patients, oral treatment
Externí odkaz:
https://doaj.org/article/0f213e589b174cc3ad9814872f2e3b93
Autor:
Tara R. Price, Donnie S. Stapleton, Kathryn L. Schueler, Marie K. Norris, Brian W. Parks, Brian S. Yandell, Gary A. Churchill, William L. Holland, Mark P. Keller, Alan D. Attie
Publikováno v:
bioRxiv
We and others have previously shown that genetic association can be used to make causal connections between gene loci and small molecules measured by mass spectrometry in the bloodstream and in tissues. We identified a locus on mouse chromosome 7 whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4054313eac915a20d3fd182614cc415c
https://europepmc.org/articles/PMC10055419/
https://europepmc.org/articles/PMC10055419/
Novel regulators of islet function identified from genetic variation in mouse islet Ca2+oscillations
Autor:
Christopher H. Emfinger, Lauren E. Clark, Brian Yandell, Kathryn L. Schueler, Shane P. Simonett, Donnie S. Stapleton, Kelly A. Mitok, Matthew J. Merrins, Mark P. Keller, Alan D. Attie
Insufficient insulin secretion to meet metabolic demand results in diabetes. The intracellular flux of Ca2+into β-cells triggers insulin release. Since genetics strongly influences variation in islet secretory responses, we surveyed islet Ca2+dynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1df50c6b59c07f51672ceb5e0a7726fb
https://doi.org/10.1101/2022.11.26.517741
https://doi.org/10.1101/2022.11.26.517741