Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Donnie Delarosa"'
Autor:
WeiYu Lin, Daqi Xu, Cary D. Austin, Patrick Caplazi, Kate Senger, Yonglian Sun, Surinder Jeet, Judy Young, Donnie Delarosa, Eric Suto, Zhiyu Huang, Juan Zhang, Donghong Yan, Cesar Corzo, Kai Barck, Sharmila Rajan, Carrie Looney, Vineela Gandham, Justin Lesch, Wei-Ching Liang, Elaine Mai, Hai Ngu, Navneet Ratti, Yongmei Chen, Dinah Misner, Tori Lin, Dimitry Danilenko, Paula Katavolos, Estelle Doudemont, Hirdesh Uppal, Jeffrey Eastham, Judy Mak, Patricia E. de Almeida, Katherine Bao, Azadeh Hadadianpour, Mary Keir, Richard A. D. Carano, Lauri Diehl, Min Xu, Yan Wu, Robby M. Weimer, Jason DeVoss, Wyne P. Lee, Mercedesz Balazs, Kevin Walsh, Kathila R. Alatsis, Flavius Martin, Ali A. Zarrin
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal via the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or CSF1-deficient mice have revealed that IL34 function is limited to the central nervous system and sk
Externí odkaz:
https://doaj.org/article/f5bbd900f7f94b86b15fbd853c8ad352
Autor:
Sharmila Rajan, Eric Suto, Judy Young, Kevin Walsh, Wyne P. Lee, Yongmei Chen, Elaine Mai, Dinah Misner, Kate Senger, Dimitry M. Danilenko, Navneet Ratti, Ali A. Zarrin, Mary E. Keir, Patrícia de Almeida, Justin Lesch, Judy Mak, Kai H. Barck, Cary D. Austin, Cesar A. Corzo, Zhiyu Huang, Flavius Martin, Carrie Looney, Hirdesh Uppal, Hai Ngu, Yonglian Sun, Vineela D. Gandham, Wei-Ching Liang, Lauri Diehl, Surinder Jeet, Estelle Doudemont, Tori Lin, Jason DeVoss, Jeffrey Eastham, Wei Yu Lin, Azadeh Hadadianpour, Kathila R. Alatsis, Donnie Delarosa, Paula Katavolos, Juan Zhang, Katherine Bao, Richard A.D. Carano, Patrick Caplazi, Min Xu, Yan Wu, Robby M. Weimer, Mercedesz Balazs, Donghong Yan, Daqi Xu
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, Vol 10 (2019)
Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal via the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or CSF1-deficient mice have revealed that IL34 function is limited to the central nervous system and sk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fac9dee7283906729daedd8a3091d3c
https://doi.org/10.3389/fimmu.2019.02019
https://doi.org/10.3389/fimmu.2019.02019
Autor:
Leo Berezhkovsky, Mark Ultsch, Jan Smith, Wade S. Blair, Adam R. Johnson, Calum Macleod, Simon Charles Goodacre, Jason DeVoss, Jun Liang, Kapil Menghrajani, Jim Driscoll, Nico Ghilardi, Wenqian Yang, Steven Magnuson, Karen Williams, Anne van Abbema, Donnie Delarosa, Pawan Bir Kohli, Hieu Nguyen, Kathy Barrett, Steven Shia, Birong Zhang, Sue Sohn, Zhonghua Lin, Christine Chang, Mercedesz Balazs, Priscilla Mantik, Yingjie Lai, Charles Eigenbrot, Vickie Tsui, Amy Sambrone, Ivan Peng, Lawren C. Wu
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(18)
Herein we report identification of an imidazopyridine class of potent and selective TYK2 inhibitors, exemplified by prototype 6, through constraint of the rotatable amide bond connecting the pyridine and aryl rings of compound 1. Further optimization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ddf2968327d5cbe784ea14d2b0f7a5d
https://pubmed.ncbi.nlm.nih.gov/28830649
https://pubmed.ncbi.nlm.nih.gov/28830649
Autor:
Sue Sohn, Nico Ghilardi, Priscilla Mantik, Christine Chang, Mercedesz Balazs, Paul Gibbons, Jan Smith, Ivan Peng, Jason DeVoss, Bing-Yan Zhu, Kathy Barrett, Wade S. Blair, Yisong Xiao, Steven Shia, Birong Zhang, Jim Driscoll, Donnie Delarosa, Young G. Shin, Jeremy Murray, Steven Magnuson, Leo Berezhkovsky, Wenqian Yang, Anne van Abbema, Charles Eigenbrot, Lawren C. Wu, Adam R. Johnson, Pawan Bir Kohli, Vickie Tsui, Mark Ultsch, Jason Halladay, Amy Sambrone, Yingjie Lai, Joseph P. Lyssikatos, Yanzhou Liu, Kapil Menghrajani, Jun Liang, Judy Young
Publikováno v:
Journal of Medicinal Chemistry. 56:4521-4536
Herein we report our lead optimization effort to identify potent, selective, and orally bioavailable TYK2 inhibitors, starting with lead molecule 3. We used structure-based design to discover 2,6-dichloro-4-cyanophenyl and (1R,2R)-2-fluorocyclopropyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91486c8bd1e5cbb09b64ed7bef1646df
https://doi.org/10.1021/jm400266t
https://doi.org/10.1021/jm400266t
Autor:
Laura DeForge, Meijuan Zhou, Wyne P. Lee, Mark Ultsch, Martha Tan, Allen Nguyen, Mark S. Dennis, Min Xu, Elizabeth Luis, Charles Eigenbrot, Y. Gloria Meng, Steven R. Leong, Mercedesz Balazs, Anan Chuntharapai, Donghong Yan, Sree R. Ramani, Zhonghua Lin, Canio J. Refino, Donnie Delarosa, Janet Jackman, Lino C. Gonzalez, Sherry Yeh, Surinder Jeet, Terence Wong, Lawren C. Wu, Yvonne Chen, Hans Brightbill
Publikováno v:
Journal of Clinical Investigation. 120:2218-2229
IgE-mediated hypersensitivity is central to the pathogenesis of asthma and other allergic diseases. Although neutralization of serum IgE with IgE-specific antibodies is in general an efficacious treatment for allergic asthma, one limitation of this a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7985d1f3cd204c4c5836b1f53e164b
https://doi.org/10.1172/jci40141
https://doi.org/10.1172/jci40141
Autor:
James Lee, Nathan Wei, Jianyong Wang, Donnie Delarosa, Kelly M. Loyet, Fojan Zamanian, Phil Hass, Anan Chuntharapai, Wai Lee T. Wong, Michael J. Townsend, Laura DeForge, Jason Chinn
Publikováno v:
Journal of immunological methods. 362(1-2)
IL-17AA, IL-17FF, and IL-17AF are proinflammatory cytokines that have been implicated in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA). In order to measure the levels of these cytokines in synovial fluid and serum samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cfc1ba8d66d682d567e1763bf1fac3
https://pubmed.ncbi.nlm.nih.gov/20833179
https://pubmed.ncbi.nlm.nih.gov/20833179
Autor:
Yana Khalfin, Aarati Asundi, Donnie Delarosa, Laura DeForge, Chris Nelson, Richard Vandlan, Gloria Meng, Kelly Loyet
Publikováno v:
The Journal of Immunology. 190:192.7-192.7
Pro-inflammatory cytokines may be useful biomarkers for certain therapies in relevant patient samples. However, detection of low abundance cytokines in patient serum has been difficult for some cytokines, thus there is a need to develop a more sensit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a4243ea3889aaf81c53da975245a4b7
https://doi.org/10.4049/jimmunol.190.supp.192.7
https://doi.org/10.4049/jimmunol.190.supp.192.7
Autor:
WeiYu Lin, Donnie Delarosa, Judy Young, Dave Lee, Surinder Jeet, Zhiyu Huang, Jason DeVoss, Yongmei Chen, Yan Wu, Patrick Caplazi, Cary Austin, Flavius Martin
Publikováno v:
The Journal of Immunology. 190:195.9-195.9
Colony-stimulating factor1 (CSF1) and IL34 signaling through their receptor (CSF1R) promotes monocyte and macrophage (Mf) differentiation, proliferation and migration. Mf activation through CSF1/IL34 and CSF1R signaling is associated with a broad spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef292d1ac5fad2212099076747427ff3
https://doi.org/10.4049/jimmunol.190.supp.195.9
https://doi.org/10.4049/jimmunol.190.supp.195.9
Autor:
Karin Reif, Fang Shen, Yugang Wang, Tao Huang, Zhonghua Lin, Juan Zhang, Eric Suto, Charles Kaplan, Cheng Liao, Beverly King, Allen Nguyen, Sherry Yeh, Donnie Delarosa, Marya Liimatta, Henry Chiu, Zachary Sweeney, Brian Safina, Adam Johnson, Julie DeMartino, Laura DeForge, Laurent Salphati, Wyne Lee, Mercedesz Balazs, Dan Sutherlin
Publikováno v:
The Journal of Immunology. 190:68.16-68.16
The p110δ isoform of PI3K is a therapeutic target for rheumatoid arthritis, but the cellular and molecular mechanisms by which PI3K mediates inflammation are poorly understood. Here we describe a novel highly selective p110δ small molecule inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4be65a2bca4c92a1026a520c3e8b9608
https://doi.org/10.4049/jimmunol.190.supp.68.16
https://doi.org/10.4049/jimmunol.190.supp.68.16
Autor:
Lawren C Wu, Hans D Brightbill, Surinder Jeet, Zhonghua Lin, Donghong Yan, Meijuan Zhou, Martha Tan, Allen Nguyen, Sherry Yeh, Donnie Delarosa, Steven R Leong, Terence Wong, Yvonne Chen, Janet Jackman, Mark S Dennis, Anan Chuntharapai, Laura DeForge, Y Gloria Meng, Min Xu, Wyne P Lee, Canio J Refino, Mercedesz Balazs
Publikováno v:
The Journal of Immunology. 182:140.7-140.7
Anti-IgE antibody targeting of serum IgE is an efficacious treatment for asthma and other allergic diseases. Currently, therapeutic anti-IgE antibodies neutralize free serum IgE, but do not affect IgE production. We have developed monoclonal antibodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a9e0f4ef72961bc3c1cd125e1a14ff9
https://doi.org/10.4049/jimmunol.182.supp.140.7
https://doi.org/10.4049/jimmunol.182.supp.140.7