Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts.

Autor: Shin M; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Chan IL; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Cao Y; Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Gruntman AM; Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Department of Pediatrics, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, N. Grafton, MA 01536, USA., Lee J; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Sousa J; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Rodríguez TC; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Echeverria D; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Devi G; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Debacker AJ; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Moazami MP; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Krishnamurthy PM; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Rembetsy-Brown JM; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Kelly K; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Yukselen O; Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Donnard E; Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Parsons TJ; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Diabetes Center of Excellence, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Khvorova A; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Sontheimer EJ; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Maehr R; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Diabetes Center of Excellence, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Garber M; Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Watts JK; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2022 Aug 26; Vol. 50 (15), pp. 8418-8430.

Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing.

Autor: Wang IH; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Murray E; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Andrews G; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA., Jiang HC; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Park SJ; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Donnard E; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA., Durán-Laforet V; Department of Neurobiology and Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA, USA., Bear DM; Department of Psychology, Stanford University, Palo Alto, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Palo Alto, CA, USA., Faust TE; Department of Neurobiology and Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA, USA., Garber M; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA., Baer CE; Sanderson Center for Optical Imaging and Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA., Schafer DP; Department of Neurobiology and Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA, USA., Weng Z; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA., Chen F; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Macosko EZ; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Greer PL; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA. paul.greer@umassmed.edu.

Publikováno v: Nature neuroscience [Nat Neurosci] 2022 Apr; Vol. 25 (4), pp. 484-492. Date of Electronic Publication: 2022 Mar 21.

Exploring the correlation between Tom1L1 and the efficacy of neoadjuvant chemotherapy for locally progressive mid-low rectal cancer.

Autor: Li, Meng^1,2 (AUTHOR), Li, Zeyu³ (AUTHOR), Wu, Xueliang^1,4 (AUTHOR) wxlwlk@163.com, Yubo Pan⁵ (AUTHOR), Wang, Likun⁶ (AUTHOR) wanglikun@tmu.edu.cn, Xue, Jun^1,4 (AUTHOR) yfyxuejun@163.com, Li, Tian⁷ (AUTHOR) fmmult@foxmail.com

Publikováno v: BMC Cancer. 11/16/2024, Vol. 24 Issue 1, p1-13. 13p.

An atlas of cell types in the mouse epididymis and vas deferens.

Autor: Rinaldi VD; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, United States., Donnard E; Department of Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, United States., Gellatly K; Department of Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, United States., Rasmussen M; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, United States., Kucukural A; Department of Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, United States., Yukselen O; Department of Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, United States., Garber M; Department of Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, United States.; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, United States., Sharma U; Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, United States., Rando OJ; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, United States.

Publikováno v: ELife [Elife] 2020 Jul 30; Vol. 9. Date of Electronic Publication: 2020 Jul 30.

The response to single-gene duplication implicates translation as a key vulnerability in aneuploid yeast.

Autor: Dutcher, H. Auguste^1,2 (AUTHOR), Hose, James¹ (AUTHOR), Howe, Hollis¹ (AUTHOR), Rojas, Julie¹ (AUTHOR), Gasch, Audrey P.^1,2 (AUTHOR) agasch@wisc.edu

Publikováno v: PLoS Genetics. 10/25/2024, Vol. 20 Issue 10, p1-24. 24p.