Zobrazeno 1 - 10
of 304
pro vyhledávání: '"Donna. E. Davies"'
Autor:
Joseph A. Bell, Elizabeth R. Davies, Christopher J. Brereton, Milica Vukmirovic, James J.W. Roberts, Kerry Lunn, Leanne Wickens, Franco Conforti, Robert A. Ridley, Jessica Ceccato, Lucy N. Sayer, David A. Johnston, Andres F. Vallejo, Aiman Alzetani, Sanjay Jogai, Ben G. Marshall, Aurelie Fabre, Luca Richeldi, Phillip D. Monk, Paul Skipp, Naftali Kaminski, Emily Offer, Yihua Wang, Donna E. Davies, Mark G. Jones
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101695- (2024)
Summary: Matrix stiffening by lysyl oxidase-like 2 (LOXL2)-mediated collagen cross-linking is proposed as a core feedforward mechanism that promotes fibrogenesis. Failure in clinical trials of simtuzumab (the humanized version of AB0023, a monoclonal
Externí odkaz:
https://doaj.org/article/28bf070de21f4af1b6319da757012509
Publikováno v:
European Respiratory Review, Vol 15, Iss 101, Pp 172-174 (2006)
We have reported that cysteinyl-leukotrienes (cys-LTs) synergise not only with epidermal growth factor (EGF) but also with platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) to induce mitogenesis in human bronchial fibroblasts.
Externí odkaz:
https://doaj.org/article/218d40550f994220932f0219e312c84b
Autor:
Zijian Xu, Elizabeth R. Davies, Liudi Yao, Yilu Zhou, Juanjuan Li, Aiman Alzetani, Ben G. Marshall, David Hancock, Tim Wallis, Julian Downward, Rob M. Ewing, Donna E. Davies, Mark G. Jones, Yihua Wang
Publikováno v:
Genes and Diseases, Vol 11, Iss 3, Pp 101065- (2024)
The factors that determine fibrosis progression or normal tissue repair are largely unknown. We previously demonstrated that autophagy inhibition-mediated epithelial–mesenchymal transition (EMT) in human alveolar epithelial type II (ATII) cells aug
Externí odkaz:
https://doaj.org/article/5746b35799c5474dafc24942f4b6652d
Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
Autor:
Christopher J Brereton, Liudi Yao, Elizabeth R Davies, Yilu Zhou, Milica Vukmirovic, Joseph A Bell, Siyuan Wang, Robert A Ridley, Lareb SN Dean, Orestis G Andriotis, Franco Conforti, Lennart Brewitz, Soran Mohammed, Timothy Wallis, Ali Tavassoli, Rob M Ewing, Aiman Alzetani, Benjamin G Marshall, Sophie V Fletcher, Philipp J Thurner, Aurelie Fabre, Naftali Kaminski, Luca Richeldi, Atul Bhaskar, Christopher J Schofield, Matthew Loxham, Donna E Davies, Yihua Wang, Mark G Jones
Publikováno v:
eLife, Vol 11 (2022)
Extracellular matrix (ECM) stiffening with downstream activation of mechanosensitive pathways is strongly implicated in fibrosis. We previously reported that altered collagen nanoarchitecture is a key determinant of pathogenetic ECM structure-functio
Externí odkaz:
https://doaj.org/article/c0c5b337cbd6410caef8f61e40897d8b
Autor:
Charlene Akoto, Anna Willis, Chiara F. Banas, Joseph A. Bell, Dean Bryant, Cornelia Blume, Donna E. Davies, Emily J. Swindle
Publikováno v:
Viruses, Vol 14, Iss 11, p 2430 (2022)
Mast cells (MCs) are classically associated with allergic asthma but their role in antiviral immunity is unclear. Human rhinoviruses (HRVs) are a major cause of asthma exacerbations and can infect and replicate within MCs. The primary site of HRV inf
Externí odkaz:
https://doaj.org/article/78bbb4542eb34e81bc0fb3609b6d5a7c
Autor:
Yilu Zhou, Charlotte Hill, Liudi Yao, Juanjuan Li, David Hancock, Julian Downward, Mark G. Jones, Donna E. Davies, Rob M. Ewing, Paul Skipp, Yihua Wang
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Alveolar type II (ATII) epithelial cells function as stem cells, contributing to alveolar renewal, repair and cancer. Therefore, they are a highly relevant model for studying a number of lung diseases, including acute injury, fibrosis and cancer, in
Externí odkaz:
https://doaj.org/article/361c15f17b4c4c1a8cffb2ee74a92261
Autor:
Salvatore Montesanto, Natalie P Smithers, Fabio Bucchieri, Valerio Brucato, Vincenzo La Carrubba, Donna E Davies, Franco Conforti
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210830 (2019)
Development of biocompatible and functional scaffolds for tissue engineering is a major challenge, especially for development of polarised epithelia that are critical structures in tissue homeostasis. Different in vitro models of the lung epithelial
Externí odkaz:
https://doaj.org/article/f4319136e5d94e239c5b77ff2718306f
Autor:
Cornelia Blume, Jonathan David, Rachel E. Bell, Jay R. Laver, Robert C. Read, Graeme C. Clark, Donna E. Davies, Emily J. Swindle
Publikováno v:
Pathogens, Vol 9, Iss 12, p 987 (2020)
There is an error in the title [...]
Externí odkaz:
https://doaj.org/article/b43dff569dd14801a1d57a63fe1fd874
Autor:
Mark G Jones, Orestis G Andriotis, James JW Roberts, Kerry Lunn, Victoria J Tear, Lucy Cao, Kjetil Ask, David E Smart, Alessandra Bonfanti, Peter Johnson, Aiman Alzetani, Franco Conforti, Regan Doherty, Chester Y Lai, Benjamin Johnson, Konstantinos N Bourdakos, Sophie V Fletcher, Ben G Marshall, Sanjay Jogai, Christopher J Brereton, Serena J Chee, Christian H Ottensmeier, Patricia Sime, Jack Gauldie, Martin Kolb, Sumeet Mahajan, Aurelie Fabre, Atul Bhaskar, Wolfgang Jarolimek, Luca Richeldi, Katherine MA O'Reilly, Phillip D Monk, Philipp J Thurner, Donna E Davies
Publikováno v:
eLife, Vol 7 (2018)
Matrix stiffening with downstream activation of mechanosensitive pathways is strongly implicated in progressive fibrosis; however, pathologic changes in extracellular matrix (ECM) that initiate mechano-homeostasis dysregulation are not defined in hum
Externí odkaz:
https://doaj.org/article/2541e80c33c2458ba21e589aed967251
Autor:
Michael Eyres, Joseph A. Bell, Elizabeth R. Davies, Aurelie Fabre, Aiman Alzetani, Sanjay Jogai, Ben G. Marshall, David A. Johnston, Zijian Xu, Sophie V. Fletcher, Yihua Wang, Gayle Marshall, Donna E. Davies, Emily Offer, Mark G. Jones
A defining pathological feature of human lung fibrosis is localized tissue heterogeneity, which challenges the interpretation of transcriptomic studies that typically lose spatial information. Here we investigate spatial gene expression in diagnostic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c40bc01531a62cf3e61373c10a6403
https://eprints.soton.ac.uk/468826/
https://eprints.soton.ac.uk/468826/
