Predicting 5‐year dementia conversion in veterans with mild cognitive impairment

Autor: Chase Irwin, Donna Tjandra, Chengcheng Hu, Vinod Aggarwal, Amanda Lienau, Bruno Giordani, Jenna Wiens, Raymond Q. Migrino

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 1, Pp n/a-n/a (2024)

Abstract INTRODUCTION Identifying mild cognitive impairment (MCI) patients at risk for dementia could facilitate early interventions. Using electronic health records (EHRs), we developed a model to predict MCI to all‐cause dementia (ACD) conversion

Externí odkaz: https://doaj.org/article/02df87a8bd5f4b6dbdfa9050c2035b36

Characterizing heterogeneity in the progression of Alzheimer's disease using longitudinal clinical and neuroimaging biomarkers

Autor: Devendra Goyal, Donna Tjandra, Raymond Q. Migrino, Bruno Giordani, Zeeshan Syed, Jenna Wiens, Alzheimer's Disease Neuroimaging Initiative

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 629-637 (2018)

Abstract Introduction Models characterizing intermediate disease stages of Alzheimer's disease (AD) are needed to inform clinical care and prognosis. Current models, however, use only a small subset of available biomarkers, capturing only coarse chan

Externí odkaz: https://doaj.org/article/c6f5bceb656844189e7b31ee443b8ec6

Cohort discovery and risk stratification for Alzheimer's disease: an electronic health record‐based approach

Autor: Raymond Q. Migrino, Bruno Giordani, Jenna Wiens, Donna Tjandra

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Alzheimer's & Dementia : Translational Research & Clinical Interventions

Background We sought to leverage data routinely collected in electronic health records (EHRs), with the goal of developing patient risk stratification tools for predicting risk of developing Alzheimer's disease (AD). Method Using EHR data from the Un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796d6e84153edc9bf585df405599747a
https://doaj.org/article/aabf6c31a9294b3b86175d5837fb989e

Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases

Autor: Donna Tjandra, Frank Sicheri, Noah Manczyk, Maria Augusta Satori, Carsten Schwerdtfeger, Bradley B. Brasher, Sachdev S. Sidhu, Taras Makhnevych, Ashwin Seetharaman, Joan Teyra, Michael Costanzo, Charles Boone, Jason Moffat, Natasha Pascoe

Publikováno v: Journal of molecular biology. 431(6)

We applied a yeast-two-hybrid (Y2H) analysis to screen for ubiquitin variant (UbV) inhibitors of a human deubiquitinase (DUB), ubiquitin-specific protease 2 (USP2). The Y2H screen used USP2 as the bait and a prey library consisting of UbVs randomized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7ab85c1adbe5709e6bc7acf5bd35f5
https://pubmed.ncbi.nlm.nih.gov/30763569

P4-555: EHR-BASED PATIENT RISK STRATIFICATION TOOL FOR PROBABLE AD

Autor: Jenna Wiens, Donna Tjandra, Raymond Q. Migrino, Bruno Giordani

Publikováno v: Alzheimer's & Dementia. 15:P1531-P1531

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd34c5095615df96ec9eba724b6b2476
https://doi.org/10.1016/j.jalz.2019.08.102