Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Donna Shields"'
Autor:
Amitava Mukherjee, Michael W. Epperly, Renee Fisher, Wen Hou, Donna Shields, M. Saiful Huq, Phillip M. Pifer, Ria Mulherkar, Tyler J. Wilhite, Hong Wang, Peter Wipf, Joel S. Greenberger
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Cellular senescence is involved in the development of pulmonary fibrosis as well as in lung tissue repair and regeneration. Therefore, a strategy of removal of senescent cells by senolytic drugs may not produce the desired therapeutic result
Externí odkaz:
https://doaj.org/article/b26d0e1944c94d44b7aaa72439d312ac
Autor:
Diala F. Hamade, Michael W. Epperly, Renee Fisher, Wen Hou, Donna Shields, Jan-Peter van Pijkeren, Brian J. Leibowitz, Lan G. Coffman, Hong Wang, M. Saiful Huq, Ziyu Huang, Claude J. Rogers, Anda M. Vlad, Joel S. Greenberger, Amitava Mukherjee
Publikováno v:
Cancers, Vol 16, Iss 3, p 474 (2024)
Despite recent advances in cancer therapy, ovarian cancer remains the most lethal gynecological cancer worldwide, making it crucial and of the utmost importance to establish novel therapeutic strategies. Adjuvant radiotherapy has been assessed histor
Externí odkaz:
https://doaj.org/article/f567c6c83dde4f999e7419fd73b9be68
Autor:
Amitava Mukherjee, Michael W. Epperly, Donna Shields, Wen Hou, Renee Fisher, Diala Hamade, Hong Wang, M. Saiful Huq, Riyue Bao, Tracy Tabib, Daisy Monier, Simon Watkins, Michael Calderon, Joel S. Greenberger
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-13 (2021)
Abstract The role of cellular senescence in radiation-induced pulmonary fibrosis (RIPF) and the underlying mechanisms are unknown. We isolated radiation-induced senescent tdTOMp16 positive mesenchymal stem cells, established their absence of cell div
Externí odkaz:
https://doaj.org/article/0d506b65bfd24c52a6be862101f64fb6
Autor:
Diala F. Hamade, Michael W. Epperly, Renee Fisher, Wen Hou, Donna Shields, Jan-Peter van Pijkeren, Amitava Mukherjee, Jian Yu, Brian J. Leibowitz, Anda M. Vlad, Lan Coffman, Hong Wang, M. Saiful Huq, Ziyu Huang, Claude J. Rogers, Joel S. Greenberger
Publikováno v:
Cancers, Vol 15, Iss 6, p 1670 (2023)
Irradiation can be an effective treatment for ovarian cancer, but its use is limited by intestinal toxicity. Thus, strategies to mitigate toxicity are important and can revitalize the current standard of care. We previously established that LR-IL-22
Externí odkaz:
https://doaj.org/article/a74ebfc9d88d45a5be311e90d1ef6636
Autor:
Alexis Espinal, Michael W. Epperly, Amitava Mukherjee, Renee Fisher, Donna Shields, Hong Wang, M. Saiful Huq, Diala Fatima Hamade, Anda M. Vlad, Lan Coffman, Ronald Buckanovich, Jian Yu, Brian J. Leibowitz, Jan-Peter van Pijkeren, Ravi B. Patel, Donna Stolz, Simon Watkins, Asim Ejaz, Joel S. Greenberger
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5616 (2022)
(1) Background: The systemic administration of therapeutic agents to the intestine including cytokines, such as Interleukin-22 (IL-22), is compromised by damage to the microvasculature 24 hrs after total body irradiation (TBI). At that time, there is
Externí odkaz:
https://doaj.org/article/146f8975d3714d18886ab7aac7eccc6f
Autor:
Diala F. Hamade, Alexis Espinal, Jian Yu, Brian J. Leibowitz, Renee Fisher, Wen Hou, Donna Shields, Jan-Peter van Pijkeren, Amitava Mukherjee, Michael W. Epperly, Anda M. Vlad, Lan Coffman, Hong Wang, M. Saiful Huq, Ravi Patel, Jason Huang, Joel S. Greenberger
Publikováno v:
Radiat Res
Oral administration (gavage) of a second-generation probiotic, Lactobacillus reuteri (L. reuteri), that releases interleukin-22 (LR-IL-22) at 24 h after total-body irradiation (TBI) mitigates damage to the intestine. We determined that LR-IL-22 also
Autor:
Joel S. Greenberger, Xichen Zhang, Simon C. Watkins, Wen Hou, Jan-Peter van Pijkeren, Peter Wipf, Laura M. Alexander, Renee Fisher, Donna Shields, Jian Yu, Michael W. Epperly, Hong Wang, Liang Wei, Brian J. Leibowitz
Publikováno v:
In Vivo. 34:39-50
Background/aim Intestinal damage induced by total body irradiation (TBI) reduces leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5)-expressing stem cells, goblet, and Paneth cells, breaching the epithelial lining, and facilitating bac
Autor:
Hong Wang, Michael W. Epperly, Donna Shields, Luis A. Ortiz, Amitava Mukherjee, Joel S. Greenberger, Wen Hou, Renee Fisher
Publikováno v:
In Vivo
Background/Aim: The role of senescence and bone marrow-derived cells in silica-induced pulmonary fibrosis is unknown. Materials and Methods: C57BL/6HNsd, p16(+/LUC), and tdTOMp16+ mice were intratracheally injected with 200 mg/kg crystalline silica o
Autor:
Daisy Monier, Wen Hou, Hong Wang, Simon C. Watkins, M. Saiful Huq, Riyue Bao, Amitava Mukherjee, Renee Fisher, Tracy Tabib, Michael J. Calderon, Diala Fatima Hamade, Joel S. Greenberger, Michael W. Epperly, Donna Shields
Publikováno v:
Cell Death Discovery
Cell Death Discovery, Vol 7, Iss 1, Pp 1-13 (2021)
Cell Death Discovery, Vol 7, Iss 1, Pp 1-13 (2021)
The role of cellular senescence in radiation-induced pulmonary fibrosis (RIPF) and the underlying mechanisms are unknown. We isolated radiation-induced senescent tdTOMp16 positive mesenchymal stem cells, established their absence of cell division, th
Autor:
Wen Hou, Michael W. Epperly, Darcy Franicola, Lora H. Rigatti, Hong Wang, Donna Shields, Renee Fisher, Joel S. Greenberger, Xichen Zhang
Publikováno v:
In Vivo. 33:303-311
Aim To demonstrate that Fanconi anemia complementation group D2-deficient (Fancd2-/-) hematopoietic progenitor cell lines can be transformed by transfection with a plasmid containing either the E6 or E7 oncogene of human papillomavirus (HPV) to gener