Výsledky vyhledávání - "Donna S. Dorow"

Differential 18F-FDG and 3′-Deoxy-3′-18F-Fluorothymidine PET Responses to Pharmacologic Inhibition of the c-MET Receptor in Preclinical Tumor Models

Autor: Susan Jackson, Grant A. McArthur, Donna S. Dorow, Rodney J. Hicks, David Binns, Maria E. Arango, Benjamin Solomon, Carleen Cullinane, James G. Christensen, Richard J. Young, Ekaterina Bogatyreva

Publikováno v: Journal of Nuclear Medicine. 52:1261-1267

The ability of PET to image functional changes in tumors is increasingly being used to evaluate response and predict clinical benefit to conventional and novel cancer therapies. Although the use of (18)F-FDG PET is well established, 3'-deoxy-3'-(18)F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4987747d482f48b276857715fa8b9628
https://doi.org/10.2967/jnumed.110.086967

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Radiosynthesis and Biological Evaluation of l- and d-S-(3-[18F]Fluoropropyl)homocysteine for Tumor Imaging Using Positron Emission Tomography

Autor: Donna S. Dorow, Thomas Bourdier, Christopher J. R. Fookes, Timothy Jackson, Delphine Denoyer, Rachael Shepherd, Andrew Katsifis, Paula Berghofer, Marie-Claude Gregoire, Rodney J. Hicks, Ivan Greguric

Publikováno v: Journal of Medicinal Chemistry. 54:1860-1870

Interest in radiolabeled amino acids for metabolic imaging of cancer and limitations with [(11)C]methionine has prompted the development of a new (18)F-labeled methionine derivative S-(3-[(18)F]fluoropropyl)homocysteine ([(18)F]FPHCys). The L and D e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78988d611c44b947c86c79fbd74acccb
https://doi.org/10.1021/jm101513q

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18F-FLT PET as a Surrogate Marker of Drug Efficacy During mTOR Inhibition by Everolimus in a Preclinical Cisplatin-Resistant Ovarian Tumor Model

Autor: Peter Roselt, Nicolas Aide, Grant A. McArthur, Oliver C. Neels, Rodney J. Hicks, Kelly Waldeck, Donna S. Dorow, Carleen Cullinane, Kathryn M. Kinross

Publikováno v: Journal of Nuclear Medicine. 51:1559-1564

Targeting the mammalian target of rapamycin (mTOR) pathway is a potential means of overcoming cisplatin resistance in ovarian cancer patients. Because mTOR inhibition affects cell proliferation, we aimed to study whether 3'-deoxy-3'-(18)F-fluorothymi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04fbba57b4c857b882ccddf6109f5de
https://doi.org/10.2967/jnumed.109.073288

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High-Contrast PET of Melanoma Using 18F-MEL050, a Selective Probe for Melanin with Predominantly Renal Clearance

Autor: Donna S. Dorow, Stephen R. Taylor, Nicolas Aide, Ivan Greguric, Andrew Katsifis, Rodney J. Hicks, Peter Roselt, Delphine Denoyer, Oliver C. Neels

Publikováno v: Journal of Nuclear Medicine. 51:441-447

The aim of this study was to evaluate the novel probe 18F-6-fluoro-N-[2-(diethylamino)ethyl] pyridine-3-carboxamide (18F-MEL050) for the imaging of primary and metastatic melanoma. Methods: PET using 18F-MEL050 was performed in murine models of melan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5d4db50388345d9a4a0078c4eca00d
https://doi.org/10.2967/jnumed.109.070060

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PET tracer development - a tale of mice and men

Autor: Peter Roselt, Donna S. Dorow, Rodney J. Hicks

Publikováno v: Cancer Imaging

PET scanning is an emerging technology for the clinical evaluation of many disease processes in man. The vast majority of clinical positron emission tomography (PET) studies are performed using a single tracer, fluorodeoxyglucose. Despite the excelle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a143837008ac48ef43b71db7a1c7e1
https://doi.org/10.1102/1470-7330.2006.9098

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An In vivo Tumor Model Exploiting Metabolic Response as a Biomarker for Targeted Drug Development

Autor: Rodney J. Hicks, David Binns, Nelly Conus, David Thomas, Maya Kansara, Grant A. McArthur, Leonie K. Ashman, Donna S. Dorow, Carleen Cullinane

Publikováno v: Cancer Research. 65:9633-9636

In vivo models that recapitulate oncogene-dependent tumorigenesis will greatly facilitate development of molecularly targeted anticancer therapies. We have developed a model based on activating mutations in c-KIT in gastrointestinal stromal tumors (G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e7815e52da548b16406660dcbe1f8b
https://doi.org/10.1158/0008-5472.can-05-2285

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Mixed Lineage Kinase 2 Interacts with Clathrin and Influences Clathrin-coated Vesicle Trafficking

Autor: Richard J. Simpson, Hong Ji, Leanne Bowes, David F. Frecklington, Martha E. Linsenmeyer, Yee-Foong Mok, Nelly Marmy-Conus, Donna S. Dorow, Shiva Akbarzadeh, Lisa Devereux

Publikováno v: Journal of Biological Chemistry. 277:36280-36287

Mixed lineage kinase 2 (MLK2) is a protein kinase that signals in the stress-activated Jun N-terminal kinase signal transduction pathway. We used immunoprecipitation and mass spectrometric analysis to identify MLK2-binding proteins in cell lines with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d00485ec3283646fe8cb2709c12b66
https://doi.org/10.1074/jbc.m204626200

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Cancer proteomics: from signaling networks to tumor markers

Autor: Richard J. Simpson, Donna S. Dorow

Publikováno v: Trends in Biotechnology. 19:S40-S48

Along with the great strides that have been made towards understanding cancer, has come a realization of the complexity of molecular events that lead to malignancy. Proteomics-based approaches, which enable the quantitative investigation of both cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6a57cfe954a84a52400ca19342ad7b
https://doi.org/10.1016/s0167-7799(01)01801-7

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Kainate Receptor Activation Induces Mixed Lineage Kinase-mediated Cellular Signaling Cascades via Post-synaptic Density Protein 95

Autor: John Marshall, Donna S. Dorow, Elizabeth P. Garcia, Anneli Savinainen, Ya Fang Liu

Publikováno v: Journal of Biological Chemistry. 276:11382-11386

Kainate receptor glutamate receptor 6 (GluR6) subunit-deficient and c-Jun N-terminal kinase 3 (JNK3)-null mice share similar phenotypes including resistance to kainite-induced epileptic seizures and neuronal toxicity (Yang, D. D., Kuan, C-Y., Whitmar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc84cc2cf93359ea01467d1f3c52cc9
https://doi.org/10.1074/jbc.m100190200

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Activated JNK Phosphorylates the C-terminal Domain of MLK2 That Is Required for MLK2-induced Apoptosis

Autor: Donna S. Dorow, Gareth Price, Ya Fang Liu, David R. Phelan

Publikováno v: Journal of Biological Chemistry. 276:10801-10810

MAP kinase signaling pathways are important mediators of cellular responses to a wide variety of stimuli. Signals pass along these pathways via kinase cascades in which three protein kinases are sequentially phosphorylated and activated, initiating a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9595fc9ea0745d6fcc06cfa934730c72
https://doi.org/10.1074/jbc.m008237200

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