Výsledky vyhledávání - "Donna R Newman"

Akademický článek

Whole-genome analysis of temporal gene expression during early transdifferentiation of human lung alveolar epithelial type 2 cells in vitro.

Autor: Helena Morales Johansson, Donna R Newman, Philip L Sannes

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93413 (2014)

It is generally accepted that the surfactant-producing pulmonary alveolar epithelial type II (AT2) cell acts as the progenitor of the type I (AT1) cell, but the regulatory mechanisms involved in this relationship remain the subject of active investig

Externí odkaz: https://doaj.org/article/6c2ae424b2b34a518510e72b84b0bc6a

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Sustained Release of Protein Therapeutics from Subcutaneous Thermosensitive Biocompatible and Biodegradable Pentablock Copolymers (PTSgels)

Autor: Santhi Abbaraju, Mary Walsh, Brian C. Gilger, Poonam Velagaleti, Rasidul Amin, Sidney L Weiss, Jacklyn H. Salmon, Ulrich Grau, Donna R. Newman, Elizabeth Schaefer

Publikováno v: Journal of Drug Delivery, Vol 2016 (2016)
Journal of Drug Delivery

Objective. To evaluate thermosensitive, biodegradable pentablock copolymers (PTSgel) for sustained release and integrity of a therapeutic protein when injected subcutaneously. Materials and Methods. Five PTSgels with PEG-PCL-PLA-PCL-PEG block arrange

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462e01ef1596c512e700286e96128766
https://doi.org/10.1155/2016/2407459

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Expression of Fibroblast Growth Factor 9 in Normal Human Lung and Idiopathic Pulmonary Fibrosis

Autor: Philip L. Sannes, Donna R. Newman, Emily Coffey

Publikováno v: Journal of Histochemistry & Cytochemistry. 61:671-679

The fibroblast growth factor (FGF) family of signaling ligands contributes significantly to lung development and maintenance in the adult. FGF9 is involved in control of epithelial branching and mesenchymal proliferation and expansion in developing l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5942f723779c42e6b5d0dc5796123d09
https://doi.org/10.1369/0022155413497366

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Over-expression of human endosulfatase-1 exacerbates cadmium-induced injury to transformed human lung cells in vitro

Autor: Donna R. Newman, James C. Bonner, Philip L. Sannes, Huiying Zhang

Publikováno v: Toxicology and Applied Pharmacology. 265:27-42

Environmental exposure to cadmium is known to cause damage to alveolar epithelial cells of the lung, impair their capacity to repair, and result in permanent structural alterations. Cell surface heparan sulfate proteoglycans (HSPGs) can modulate cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::964430283749f1e88ba70a8c191ebd55
https://doi.org/10.1016/j.taap.2012.09.008

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Fibroblast growth factor-binding protein and N-deacetylase/N-sulfotransferase-1 expression in type II cells is modulated by heparin and extracellular matrix

Autor: Donna R. Newman, Philip L. Sannes, Eric Walsh, K. B. C. Apparao

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 293:L1314-L1320

Fibroblast growth factors (FGFs) play critical roles in development, maintenance, and repair following injury or disease in the lung. Their activity is modulated by a variety of factors, including FGF-binding protein (FGF-BP; HBp-17) and N-deacetylas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df2c0ef9e9d122f5dfb581f737e7eaf
https://doi.org/10.1152/ajplung.00211.2007

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Heparin and LPS-induced COX-2 expression in airway cells: a link between its anti-inflammatory effects and GAG sulfation

Autor: Helena Morales Johansson, Donna R. Newman, Philip L. Sannes, Na Young Yi, Huiying Zhang

Publikováno v: Experimental lung research. 41(9)

Previous studies have indicated that the sulfated polysaccharide heparin has anti-inflammatory effects. However, the mechanistic basis for these effects has not been fully elucidated.NCI-H292 (mucoepidermoid) and HBE-1 (normal) human bronchial epithe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bada853787569d1a4ecd51c4e6a300a
https://pubmed.ncbi.nlm.nih.gov/26495958

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Expression of WNT5A in Idiopathic Pulmonary Fibrosis and Its Control by TGF-β and WNT7B in Human Lung Fibroblasts

Autor: Katherine Hanrahan, W. Shane Sills, Elizabeth Cook, Amanda L. Ziegler, Donna R. Newman, Philip L. Sannes, Kathleen McGinnis Tidd

Publikováno v: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 64(2)

The wingless (Wnt) family of signaling ligands contributes significantly to lung development and is highly expressed in patients with usual interstitial pneumonia (UIP). We sought to define the cellular distribution of Wnt5A in the lung tissue of pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5f2b875e04d3afca89a911ff5599ac
https://pubmed.ncbi.nlm.nih.gov/26538547

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Heparin Inhibits DNA Synthesis and Gene Expression in Alveolar Type II Cells

Autor: Philip L. Sannes, Donna R. Newman, Jody Khosla, Cheng-Ming Li

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 27:345-352

Responses of isolated type II alveolar cells to fibroblast growth factors (FGF) have been shown to be sensitive to the level of sulfation in extracellular matrix (ECM) substrata. These observations may reflect the specific in situ distribution and le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde31f5fba0d33d48a72cd83c6b328c3
https://doi.org/10.1165/rcmb.2002-0002oc

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