Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Donna Petch"'
Autor:
Camilo E. Quevedo, Abimael Cruz-Migoni, Nicolas Bery, Ami Miller, Tomoyuki Tanaka, Donna Petch, Carole J. R. Bataille, Lydia Y. W. Lee, Phillip S. Fallon, Hanna Tulmin, Matthias T. Ehebauer, Narcis Fernandez-Fuentes, Angela J. Russell, Stephen B. Carr, Simon E. V. Phillips, Terence H. Rabbitts
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Intracellular antibodies can inhibit disease-relevant protein interactions, but inefficient cellular uptake limits their utility. Using a RAS-targeting intracellular antibody as a screening tool, the authors here identify small molecules that inhibit
Externí odkaz:
https://doaj.org/article/67c80be1d0a14b3aa0feecf6b7e3b832
Autor:
Simon E. V. Phillips, Carole J. R. Bataille, Tomoyuki Tanaka, Angela J. Russell, Abimael Cruz, Terence H. Rabbitts, Donna Petch, Hanna Tulmin, Camilo E. Quevedo
Our aim was to develop methods to employ intracellular antibody fragments as lead macromolecules for small compound selections. We have used this approach to identify small molecules binding to mutant RAS with potential to inhibit the RAS-effector in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33be7ae7e712680855e624393fbfcb4f
https://doi.org/10.1158/1538-7445.am2017-lb-068
https://doi.org/10.1158/1538-7445.am2017-lb-068
Autor:
Rosaleen J. Anderson, Donna Petch, Paul W. Groundwater, Simon P. Mackay, Ran Liu, Suja E. George, Andrew Paul, David A. P. Small, David E. Hibbs, Anne E. Cunningham
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:5901-5914
Hit compounds from in silico screening for inhibitors of the EGFR dimerization process were evaluated for their anti-proliferative (CCD-1106 keratinocytes) and anti-oxidant (TBA assay) activity and their effect on EGFR dimerization (BS(3) chemical cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc5994caed5c61c136886f9f2455665
https://doi.org/10.1016/j.bmc.2012.07.048
https://doi.org/10.1016/j.bmc.2012.07.048