Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Donna Pearce"'
Autor:
Guan-Da Syu, Shih-Chin Wang, Guangzhong Ma, Shuang Liu, Donna Pearce, Atish Prakash, Brandon Henson, Lien-Chun Weng, Devlina Ghosh, Pedro Ramos, Daniel Eichinger, Ignacio Pino, Xinzhong Dong, Jie Xiao, Shaopeng Wang, Nongjian Tao, Kwang Sik Kim, Prashant J. Desai, Heng Zhu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
G protein-coupled receptors (GPCRs) are important targets for drug discovery. Here, the authors develop a Virion Display array of 315 functional non-odorant GPCRs, providing a platform for high-throughput, unbiased screening for small molecule drugs,
Externí odkaz:
https://doaj.org/article/7a853ae4a1c340a6a212e52e60b8d905
Autor:
Veronica F. Colomer Gould, Daniel Goti, Donna Pearce, Guillermo A. Gonzalez, Hong Gao, Mario Bermudez de Leon, Nancy A. Jenkins, Neal G. Copeland, Christopher A. Ross, Dale R. Brown
Publikováno v:
Neurobiology of Disease, Vol 27, Iss 3, Pp 362-369 (2007)
Machado–Joseph disease also called spinocerebellar ataxia type 3 (MJD/SCA3) is a hereditary and neurodegenerative movement disorder caused by ataxin-3 with a polyglutamine expansion (mutant ataxin-3). Neuronal loss in MJD/SCA3 is associated with a
Externí odkaz:
https://doaj.org/article/195a5ddb356a403a9dced3088e8de034
Autor:
Shaohui Hu, Donna Pearce, Jessica Ho, Yingzhu Feng, Kwang Sik Kim, Bochu Wang, Heng Zhu, Chien Sheng Chen, Prashant Desai
Publikováno v:
Analytical Chemistry. 90:10958-10966
Bacterial meningitis in neonates and infants is an acute lethal disease and occurs in response to microbial exploitation of the blood-brain barrier (BBB), resulting in the intracranial inflammation. Several pathogens, such as Escherichia coli ( E. co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9d01fbdb60d0e86d4ef22c8a7da358
https://doi.org/10.1021/acs.analchem.8b02513
https://doi.org/10.1021/acs.analchem.8b02513
Autor:
Jie Xiao, Guangzhong Ma, Daniel Eichinger, Pedro Ramos, Ignacio Pino, Nongjian Tao, Devlina Ghosh, Shaopeng Wang, Brandon Henson, Donna Pearce, Shuang Liu, Lien Chun Weng, Xinzhong Dong, Kwang Sik Kim, Guan Da Syu, Heng Zhu, Atish Prakash, Prashant Desai, Shih Chin Wang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
Human G protein-coupled receptors (GPCRs) respond to various ligands and stimuli. However, GPCRs rely on membrane for proper folding, making their biochemical properties difficult to study. By displaying GPCRs in viral envelopes, we fabricated a Viri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cba37878b4f00e9bee85c274022e50
https://doi.org/10.1038/s41467-019-09938-9
https://doi.org/10.1038/s41467-019-09938-9
Autor:
John R. Perfect, Longkun Zhu, Kyung J. Kwon-Chung, Ravi Maruvada, Kwang Sik Kim, Yi Zheng, Donna Pearce
Publikováno v:
Cellular Microbiology. 14:1544-1553
Cryptococcus neoformans (C. neoformans) penetration into the central nervous system (CNS) requires traversal of the blood-brain barrier that is composed of a single layer of human brain microvascular endothelial cells (HBMEC), but the underlying mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::662c7fdb269dbd3ecac86244ead4f909
https://doi.org/10.1111/j.1462-5822.2012.01819.x
https://doi.org/10.1111/j.1462-5822.2012.01819.x
Publikováno v:
Infection and Immunity. 78:3554-3559
Escherichia coli meningitis is an important cause of mortality and morbidity, and a key contributing factor is our incomplete understanding of the pathogenesis of E. coli meningitis. We have shown that E. coli penetration into the brain requires E. c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33888e8b0fab21171813793ff2bce826
https://doi.org/10.1128/iai.00336-10
https://doi.org/10.1128/iai.00336-10
Autor:
Dale R. Brown, Veronica F. Colomer Gould, Daniel Goti, Donna Pearce, Neal G. Copeland, Christopher A. Ross, Guillermo A. Gonzalez, Nancy A. Jenkins, Mario Bermúdez de León, Hong Gao
Publikováno v:
Neurobiology of Disease, Vol 27, Iss 3, Pp 362-369 (2007)
Machado-Joseph disease also called spinocerebellar ataxia type 3 (MJD/SCA3) is a hereditary and neurodegenerative movement disorder caused by ataxin-3 with a polyglutamine expansion (mutant ataxin-3). Neuronal loss in MJD/SCA3 is associated with a mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058b15997af0f605b041c5d46f82e6c9
http://www.sciencedirect.com/science/article/pii/S0969996107001167
http://www.sciencedirect.com/science/article/pii/S0969996107001167
Autor:
Francescopaolo Di Cello, Monique F. Stins, Carlos A. Pardo, Kwang Sik Kim, Anat Erdreich-Epstein, Donna Pearce
Publikováno v:
Laboratory Investigation. 83:1787-1798
Central nervous system dysfunction is commonly observed in children with HIV-1 infection, but the mechanisms whereby HIV-1 causes encephalopathy are not completely understood. We have previously shown that human brain microvascular endothelial cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ef0d787cd86c83bf6e4ac8f8655fc0
https://doi.org/10.1097/01.lab.0000107008.13321.c8
https://doi.org/10.1097/01.lab.0000107008.13321.c8
Group B Streptococcus (GBS) is the most common bacterium causing neonatal meningitis, and neonatal GBS meningitis continues to be an important cause of mortality and morbidity. Here we provide the first direct evidence that host cytosolic phospholipa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94bdc9ce6e2296f017a32afaafff385d
https://europepmc.org/articles/PMC3187255/
https://europepmc.org/articles/PMC3187255/
Publikováno v:
Infection and immunity. 78(8)
Escherichia coli meningitis is an important cause of mortality and morbidity, and a key contributing factor is our incomplete understanding of the pathogenesis of E. coli meningitis. We have shown that E. coli penetration into the brain requires E. c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07ca1219a61685fb30694a59b98f897d
https://pubmed.ncbi.nlm.nih.gov/20515928
https://pubmed.ncbi.nlm.nih.gov/20515928