Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Donna Pack"'
Autor:
Donna Pack, Val Vallyathan, Steve Leonard, Marc B. Schenker, Vince Castranova, Robert J. Lawson
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 70:95-106
Agricultural workers are exposed to a variety of airborne dusts, including crystalline silica and other inorganic minerals. This study was designed to characterize the organic and inorganic components of agricultural dusts in California grape- and ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37342154a57e4c16b7d6644d130e9b43
https://doi.org/10.1080/15287390600747825
https://doi.org/10.1080/15287390600747825
Correlates of Oxidative Stress and Free-Radical Activity in Serum from Asymptomatic Shipyard Welders
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 172:1541-1548
Rationale: Oxidative stress is believed to play a key role in the development of welding-induced disease. Objectives: This study investigated the effects of welding fume exposure on correlates of oxidative stress in the serum of asymptomatic shipyard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0284b307f14c9574340835f1ea144f5
https://doi.org/10.1164/rccm.200409-1222oc
https://doi.org/10.1164/rccm.200409-1222oc
Autor:
K. Murali Krishna Rao, Terence Meighan, Donna Pack, Mark Barger, Jane Y. C. Ma, Val Vallyathan
Publikováno v:
Environmental Health Perspectives
Diesel exhaust particles (DEPs) at three concentrations (5, 35, and 50 mg/kg body weight) were instilled into rats intratracheally. We studied gene expression at 1, 7, and 30 days postexposure in cells obtained by bronchoalveolar lavage (BAL) and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e99db9eac16004df3250e5e531cd10e
https://doi.org/10.1289/ehp.7696
https://doi.org/10.1289/ehp.7696
Autor:
Jeff McLaurin, Victor A. Robinson, Alexander W. Teass, Douglas Landsittel, Patsy Willard, Donna Pack, Dawn Ramsey, Ann F. Hubbs, Dale W. Porter, Lyndell Millecchia, Vincent Castranova, Amir Khan
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 283:L485-L493
In previous reports from this study, measurements of pulmonary inflammation, bronchoalveolar lavage cell cytokine production and nuclear factor-κB activation, cytotoxic damage, and fibrosis were detailed. In this study, we investigated the temporal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87aab098fea57c368f8cbe8141d63cb2
https://doi.org/10.1152/ajplung.00427.2001
https://doi.org/10.1152/ajplung.00427.2001
Changes in Bronchoalveolar Lavage Indices Associated with Radiographic Classification in Coal Miners
Autor:
Val Vallyathan, Vincent Castranova, Stephen S. Leonard, Leroy N. Lapp, Donna Pack, Micheal Goins, Xianglin Shi
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 162:958-965
Previous studies on symptomatic coal miners have shown that alveolar macrophages, recovered by bronchoalveolar lavage (BAL), release excessive amounts of reactive oxygen species (ROS) and inflammatory cytokines. It has been proposed that these secret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d8dccb2ce4bee24eeb00223cb3f6e7
https://doi.org/10.1164/ajrccm.162.3.9909074
https://doi.org/10.1164/ajrccm.162.3.9909074
Autor:
Val Vallyathan, Donna Pack, Vincent Castranova, Mark Barger, Dawn Ramsey, Steven S. Leonard, Jane Y. C. Ma, Jeffrey L. McLaurin, Alex W. Teass, Nar S. Dalal
Publikováno v:
Environmental Health Perspectives
Fracturing quartz produces silica-based radicals on the fracture planes and generates hydroxyl radicals (.OH) in aqueous media. .OH production has been shown to be directly associated with quartz-induced cell damage and phagocyte activation in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0edc79a0490e378cc1d17e91d8a4e2
https://doi.org/10.1289/ehp.97105s51319
https://doi.org/10.1289/ehp.97105s51319
Autor:
Periannan Kuppusamy, Michael Chzhan, Val Vallyathan, Sherry P. Sanders, Jay L. Zweir, Donna Pack, Stephen S. Leonard
Publikováno v:
Molecular and Cellular Biochemistry. 168:125-132
We hypothesized that reactive oxygen species (ROS) may be involved in the pathogenesis of silicosis. To investigate ROS' dependent pathophysiological processes during silicosis we studied the kinetic clearance of instilled stable nitroxide radicals (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aa8c9f24a06ea427b1b3f374ec4ce08
https://doi.org/10.1023/a:1006850920080
https://doi.org/10.1023/a:1006850920080
Autor:
Dawn Ramsey, Jean Xiang, Dale A. Shoemaker, Nar S. Dalai, Linda Bowman, Alex W. Teass, Jack Blackford, Diane Schwegler-Berry, Jeff McLaurin, Paul A. Baron, Vincent Castranova, Donna Pack, Ann F. Hubbs, Kenneth C. Weber, Mark Barger, Amir Khan, Charles P. Childress, Jane Y. C. Ma, Val Vallyathan, Jack R. Pretty, Lloyd E. Stettler, William H. Pailes, Philip R. Miles, Richard D. Dey
Publikováno v:
Applied Occupational and Environmental Hygiene. 11:937-941
We have reported previously that grinding crystalline silica generates radicals on its cleavage planes and that this fresh dust is more cytotoxic in vitro than aged silica. The objective of the present study was to determine if freshly fractured sili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::259e87c699a8f8c733b6ad953e0ac701
https://doi.org/10.1080/1047322x.1996.10389993
https://doi.org/10.1080/1047322x.1996.10389993
Publikováno v:
Free Radical Biology and Medicine. 18:11-20
Occupational exposure to coal mine dust causes coal workers' pneumoconiosis (CWP) and other pulmonary diseases by mechanisms that remain unclear. Because the hydroxyl radicals (.OH) may play an important role in the pathogenesis of CWP, we studied th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790f1297261ba253906fac4afe691125
https://doi.org/10.1016/0891-5849(94)e0094-y
https://doi.org/10.1016/0891-5849(94)e0094-y
Publikováno v:
Experimental and Molecular Pathology. 58:114-126
To better characterize the hepatotoxicity of acetaminophen, the effects of this drug were investigated on isolated liver cells from a species relatively resistant to acetaminophen toxicity, rainbow trout. At high concentrations of acetaminophen (2-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::376534ebcf92fd7183f14bb786c2c182
https://doi.org/10.1006/exmp.1993.1010
https://doi.org/10.1006/exmp.1993.1010