Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Donna O. Debets"'
Autor:
Donna O. Debets, Erik L. de Graaf, Marte C. Liefaard, Gabe S. Sonke, Esther H. Lips, Anna Ressa, Maarten Altelaar
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109858- (2024)
Summary: In this study, we measured the kinase activity profiles of 32 pre-treatment tumor biopsies of HER2-positive breast cancer patients. The aim of this study was to assess the prognostic potential of kinase activity levels, to identify potential
Externí odkaz:
https://doaj.org/article/bfdbc26b61c74528a8ee376a35d970f6
Autor:
Isabel Mayayo‐Peralta, Donna O. Debets, Stefan Prekovic, Karianne Schuurman, Suzanne Beerthuijzen, Mathilde Almekinders, Joyce Sanders, Cathy B. Moelans, Sandra Saleiro, Jelle Wesseling, Paul J. vanDiest, Rui Henrique, Carmen Jerónimo, Maarten Altelaar, Wilbert Zwart
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 156-169 (2024)
Breast cancer (BCa) is a highly heterogeneous disease, with hormone receptor status being a key factor in patient prognostication and treatment decision‐making. The majority of primary tumours are positive for oestrogen receptor alpha (ERα), which
Externí odkaz:
https://doaj.org/article/729f177a629a4bda894d9576a75e0d22
Autor:
Stefan Prekovic, Karianne Schuurman, Isabel Mayayo-Peralta, Anna G. Manjón, Mark Buijs, Selçuk Yavuz, Max D. Wellenstein, Alejandro Barrera, Kim Monkhorst, Anne Huber, Ben Morris, Cor Lieftink, Theofilos Chalkiadakis, Ferhat Alkan, Joana Silva, Balázs Győrffy, Liesbeth Hoekman, Bram van den Broek, Hans Teunissen, Donna O. Debets, Tesa Severson, Jos Jonkers, Timothy Reddy, Karin E. de Visser, William Faller, Roderick Beijersbergen, Maarten Altelaar, Elzo de Wit, Rene Medema, Wilbert Zwart
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Glucocorticoids (GC) are reported to block cancer cell proliferation, but the mode of action is unclear. Here the authors show that glucocorticoid receptor activation induces cancer cell dormancy in lung cancer by regulating CDKN1C expression through
Externí odkaz:
https://doaj.org/article/e4c712e9c2534821b3dbea828efb9470
Autor:
Donna O. Debets, Erik L. de Graaf, Marte C. Liefaard, Gabe S. Sonke, Esther H. Lips, Anna Ressa, Maarten Altelaar
In this study, we measured the kinase activity profiles of 32 pre-treatment tumour biopsies of HER2-positive breast cancer patients. The aim of this study was to assess the prognostic potential of kinase activity levels to identify potential mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cb2afc7fcb3d14029024c667c1b9dc5
https://doi.org/10.1101/2022.09.23.508980
https://doi.org/10.1101/2022.09.23.508980
The MAPK-AKT-mTOR protein network integrates extra- and intracellular signals to determine cellular fate, regulating pivotal biological processes such as cell growth and metabolism. Due to this crucial role, pathway dysregulation has been implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79151dff87f322fbe025d7986f5eddf5
https://doi.org/10.1101/2022.01.17.476555
https://doi.org/10.1101/2022.01.17.476555
Autor:
Ferhat Alkan, Anna G. Manjón, Balázs Győrffy, William J. Faller, Selçuk Yavuz, Ben Morris, Bram van den Broek, Stefan Prekovic, Mark Buijs, Liesbeth Hoekman, Joana Silva, Karin E. de Visser, Hans Teunissen, Tesa M. Severson, Theofilos Chalkiadakis, Wilbert Zwart, Donna O. Debets, Max D. Wellenstein, Anne Huber, René H. Medema, Alejandro Barrera, Elzo de Wit, Isabel Mayayo-Peralta, Karianne Schuurman, Timothy E. Reddy, Cor Lieftink, Maarten Altelaar, Roderick L. Beijersbergen, Jos Jonkers, Kim Monkhorst
Publikováno v:
Nature Communications
Nature Communications, 12(1), 1. Nature Publishing Group
Nature Communications, 12(1):4360. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, 12(1), 1. Nature Publishing Group
Nature Communications, 12(1):4360. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The glucocorticoid receptor (GR) regulates gene expression, governing aspects of homeostasis, but is also involved in cancer. Pharmacological GR activation is frequently used to alleviate therapy-related side-effects. While prior studies have shown G
Autor:
Josef Vormoor, Jean-Pierre Bourquin, Jordy C.G. Van Der Zwet, Britta Vormoor, Valentina Cordo, Maarten Altelaar, Jules P.P. Meijerink, Jelle Dylus, Adolfo A. Ferrando, Jan Cools, Jessica G.C.A.M. Buijs-Gladdines, Zhongli Chen, Donna O. Debets, Guido J.R. Zaman, Willem K. Smits, Beat Bornhauser, Rob Pieters, Koichi Oshima
Publikováno v:
Blood. 136:20-20
Introduction Poor prednisolone response in the induction phase of treatment is a risk-stratification marker in the current Dutch DCOG ALL-11 treatment protocol. Physiological or mutational activation of the IL7-receptor (IL7R) provokes steroid resist