Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Donna Michelle Smith"'
Autor:
Andreas H. Jacobs, Cornelius Faber, John R. Griffiths, Donna-Michelle Smith, Kathrin Heinzmann, Davina J. Honess, Sven Hermann, Lydia Wachsmuth, Annelena Held, Sonja Schelhaas
200 mg/kg gemcitabine affect growth of A549 xenografts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046270ef7ad02677775ae5f1b99da3ae
https://doi.org/10.1158/0008-5472.22413104.v1
https://doi.org/10.1158/0008-5472.22413104.v1
Autor:
Andreas H. Jacobs, Cornelius Faber, John R. Griffiths, Donna-Michelle Smith, Kathrin Heinzmann, Davina J. Honess, Sven Hermann, Lydia Wachsmuth, Annelena Held, Sonja Schelhaas
Mean and standard deviation, as well as number of samples analyzed (in brackets), of other PET image quantification approaches.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac14323743cfeb8e9699a24a1a0d57d
https://doi.org/10.1158/0008-5472.22413098.v1
https://doi.org/10.1158/0008-5472.22413098.v1
Autor:
Neil T. Thompson, John F. Lyons, David M. Cross, Donna-Michelle Smith, E. Jonathan Lewis, Nicola G. Wallis, Ruth E. Feltell, Matthew S. Squires
Cyclin-dependent kinases (CDK), and their regulatory cyclin partners, play a central role in eukaryotic cell growth, division, and death. This key role in cell cycle progression, as well as their deregulation in several human cancers, makes them attr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6803f777c0bd846db8bcf543842eac89
https://doi.org/10.1158/1535-7163.c.6531420.v1
https://doi.org/10.1158/1535-7163.c.6531420.v1
Autor:
Neil T. Thompson, John F. Lyons, David M. Cross, Donna-Michelle Smith, E. Jonathan Lewis, Nicola G. Wallis, Ruth E. Feltell, Matthew S. Squires
Supplementary Data from Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7296b69e6a265a700d44ee128a55941b
https://doi.org/10.1158/1535-7163.22484466
https://doi.org/10.1158/1535-7163.22484466
Autor:
Andreas H. Jacobs, Cornelius Faber, John R. Griffiths, Donna-Michelle Smith, Kathrin Heinzmann, Davina J. Honess, Sven Hermann, Lydia Wachsmuth, Annelena Held, Sonja Schelhaas
Legends for Supplementary Figures S1-S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b121c4992613de4350ddcc74b8961d3e
https://doi.org/10.1158/0008-5472.22413101.v1
https://doi.org/10.1158/0008-5472.22413101.v1
Autor:
Neil T. Thompson, John F. Lyons, David M. Cross, Donna-Michelle Smith, E. Jonathan Lewis, Nicola G. Wallis, Ruth E. Feltell, Matthew S. Squires
Additional information to provide an insight into the full kinase selectivity profile of AT7519 and full details of its pharmakokinetic parameters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427461d2f3a707d2ebe36ee1f0b1e296
https://doi.org/10.1158/1535-7163.22484469
https://doi.org/10.1158/1535-7163.22484469
Autor:
Andreas H. Jacobs, Cornelius Faber, John R. Griffiths, Donna-Michelle Smith, Kathrin Heinzmann, Davina J. Honess, Sven Hermann, Lydia Wachsmuth, Annelena Held, Sonja Schelhaas
3′-Deoxy-3′-[18F]fluorothymidine positron emission tomography ([18F]FLT-PET) and diffusion-weighted MRI (DW-MRI) are promising approaches to monitor tumor therapy response. Here, we employed these two imaging modalities to evaluate the response o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93eb25f06efa2a5c6a0f1fb68b7b8cec
https://doi.org/10.1158/0008-5472.c.6508619.v1
https://doi.org/10.1158/0008-5472.c.6508619.v1
Autor:
Kathrin Heinzmann, Davina Jean Honess, David Yestin Lewis, Donna-Michelle Smith, Christopher Cawthorne, Heather Keen, Sandra Heskamp, Sonja Schelhaas, Timothy Howard Witney, Dmitry Soloviev, Kaye Janine Williams, Andreas Hans Jacobs, Eric Ofori Aboagye, John Richard Griffiths, Kevin Michael Brindle
Publikováno v:
EJNMMI Research, Vol 7, Iss 1, Pp 1-1 (2017)
Correction Unfortunately, the original version of Figs. 4, 5 and 6b in the article [1] contained errors in the n numbers as indicated on the columns. Please note that column heights and error bars in the original figures and data in the ESM tables ar
Externí odkaz:
https://doaj.org/article/50695a4166c9493a87e6dfffb426c8f3
Autor:
Duncan I. Jodrell, Daniel H. Palmer, Sarah Halford, J. Evans, Lisa V. Hampson, Balaji Venugopal, Robert McLeod, Mirela Hategan, Natalie Cook, Helen Turner, Donna Michelle Smith, Bristi Basu, Aarthi Gopinathan, Michael Nebozhyn, D. Alan Anthoney, David A. Tuveson, William P. Steward, David Propper, Hayley Farmer-Hall
Publikováno v:
Cook, N, Basu, B, Smith, D M, Gopinathan, A, Evans, J, Steward, W P, Palmer, D, Propper, D, Venugopal, B, Hategan, M, Anthoney, D A, Hampson, L V, Nebozhyn, M, Tuveson, D, Farmer-Hall, H, Turner, H, McLeod, R, Halford, S & Jodrell, D 2018, ' A phase i trial of the c-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma ', British Journal of Cancer, vol. 118, no. 6, pp. 793-801 . https://doi.org/10.1038/bjc.2017.495
British Journal of Cancer
British Journal of Cancer
Background: The Notch pathway is frequently activated in cancer. Pathway inhibition by g-secretase inhibitors has been shown to be effective in pre-clinical models of pancreatic cancer, in combination with gemcitabine. Methods: A multi-centre, non-ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45456c3b7d8810792b891ee0674468b1
https://doi.org/10.1038/bjc.2017.495
https://doi.org/10.1038/bjc.2017.495
Autor:
Edwin E. G. W. ter Voert, Wim J.G. Oyen, Peter Laverman, Arend Heerschap, Ralph Sinkus, Linda Heijmen, Donna Michelle Smith, Janneke D.M. Molkenboer-Kuenen, John R. Griffiths, Otto C. Boerman, Danny Gerrits, Davina J. Honess, Sabrina Doblas, Sandra Heskamp, Kathrin Heinzmann
Publikováno v:
Molecular Imaging and Biology, 19, 4, pp. 540-549
ResearcherID
Heskamp, S, Heijmen, L, Gerrits, D, Molkenboer-Kuenen, J D M, Ter Voert, E G W, Heinzmann, K, Honess, D J, Smith, D M, Griffiths, J R, Doblas, S, Sinkus, R, Laverman, P, Oyen, W J G, Heerschap, A & Boerman, O C 2016, ' Response Monitoring with [ 18 F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases ', Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, pp. 1-10 . https://doi.org/10.1007/s11307-016-1021-2
Molecular Imaging and Biology, 19, 540-549
ResearcherID
Heskamp, S, Heijmen, L, Gerrits, D, Molkenboer-Kuenen, J D M, Ter Voert, E G W, Heinzmann, K, Honess, D J, Smith, D M, Griffiths, J R, Doblas, S, Sinkus, R, Laverman, P, Oyen, W J G, Heerschap, A & Boerman, O C 2016, ' Response Monitoring with [ 18 F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases ', Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, pp. 1-10 . https://doi.org/10.1007/s11307-016-1021-2
Molecular Imaging and Biology, 19, 540-549
Purpose: The aim of the study was to investigate the potential of diffusion-weighted magnetic resonance imaging (DW-MRI) and 3′-dexoy-3′-[18F]fluorothymidine ([18F]FLT) positron emission tomography (PET) as early biomarkers of treatment response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f71eae15d2c19e3c70be4f21d77336c
https://hdl.handle.net/2066/177924
https://hdl.handle.net/2066/177924