Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Donna McPhie"'
Publikováno v:
Discover Mental Health, Vol 3, Iss 1, Pp 1-15 (2023)
Abstract We compared transcriptomic profiles of cerebral organoids differentiated from induced pluripotent stem cells of eight schizophrenia and eight bipolar disorder patients to identify genes that were differentially expressed in cerebral organoid
Externí odkaz:
https://doaj.org/article/b5de54aafcac4329a0e15f309b2b6c19
Autor:
Ralda Nehme, Olli Pietiläinen, Mykyta Artomov, Matthew Tegtmeyer, Vera Valakh, Leevi Lehtonen, Christina Bell, Tarjinder Singh, Aditi Trehan, John Sherwood, Danielle Manning, Emily Peirent, Rhea Malik, Ellen J. Guss, Derek Hawes, Amanda Beccard, Anne M. Bara, Dane Z. Hazelbaker, Emanuela Zuccaro, Giulio Genovese, Alexander A. Loboda, Anna Neumann, Christina Lilliehook, Outi Kuismin, Eija Hamalainen, Mitja Kurki, Christina M. Hultman, Anna K. Kähler, Joao A. Paulo, Andrea Ganna, Jon Madison, Bruce Cohen, Donna McPhie, Rolf Adolfsson, Roy Perlis, Ricardo Dolmetsch, Samouil Farhi, Steven McCarroll, Steven Hyman, Ben Neale, Lindy E. Barrett, Wade Harper, Aarno Palotie, Mark Daly, Kevin Eggan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
How the 22q11.2 deletion predisposes to psychiatric disease is unclear. Here, the authors examine living human neuronal cells and show that 22q11.2 regulates the expression of genes linked to autism during early development, and genes linked to schiz
Externí odkaz:
https://doaj.org/article/0268f31356f54488b25b24160fcce4bc
Autor:
Annie Kathuria, Kara Lopez-Lengowski, Magdalena Vater, Donna McPhie, Bruce M. Cohen, Rakesh Karmacharya
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-16 (2020)
Abstract Background Reprogramming human induced pluripotent stem cells (iPSCs) from somatic cells and generating three-dimensional brain organoids from these iPSCs provide access to live human neuronal tissue with disease-specific genetic backgrounds
Externí odkaz:
https://doaj.org/article/ed6798bd3d2b407b85ca6cf36c3125e9
Autor:
Elena H. Chartoff, Diane Damez-Werno, Kai C. Sonntag, Linda Hassinger, Daniel E. Kaufmann, Jesse Peterson, Donna McPhie, Anne M. Cataldo, Bruce M. Cohen
Publikováno v:
Stem Cells International, Vol 2011 (2011)
Bone marrow-derived mesenchymal stromal cells (MSCs) hold promise for autologous treatment of neuropathologies. Intranasal delivery is relatively noninvasive and has recently been reported to result in transport of MSCs to the brain. However, the abi
Externí odkaz:
https://doaj.org/article/b26c614f7799435a9d26af253306cefe
Abnormalities of brain connectivity are consistently observed in individuals with schizophrenias (SZ). Underlying these anomalies, convergent in vivo, post-mortem, and genomic evidence suggest abnormal oligodendrocyte (OL) development and function, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::654e09a6f0f9088d6466c123be2b2468
https://doi.org/10.21203/rs.3.rs-1808873/v1
https://doi.org/10.21203/rs.3.rs-1808873/v1