Výsledky vyhledávání - "Donna M. Romano"

Loss of Ataxin-1 Elevates BACE1 Expression and Impairs Axonal Targeting in the Cerebrum

Autor: Jaehong Suh, Mary K. Oram, Scott P. Herrick, Wilma Wasco, Kristina Mullin, Donna M. Romano, Jeremy D. Schmahmann, Mark W. Albers, Rudolph E. Tanzi, Basavaraj Hooli

Publikováno v: SSRN Electronic Journal.

Expansion of CAG trinucleotide repeats in the Ataxin-1 gene (ATXN1) causes spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disease that impairs coordinated movement and cognitive functions. ATXN1 is associated with genetic risk for Alzheime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61e93b31ce0d6829a5e87f2203644e30
https://doi.org/10.2139/ssrn.3155885

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Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription

Autor: Britt A. DiMarzio, Volodymyr Dzhala, Donna M. Romano, Jun Seok Bae, Scott P. Herrick, Wilma Wasco, Mark W. Albers, Rudolph E. Tanzi, Huda Y. Zoghbi, Kristina Mullin, Mary K. Oram, Jeremy D. Schmahmann, Yuejiao Zheng, Jaehong Suh, Basavaraj Hooli, Larissa Nitschke, Vincenzo A. Gennarino

Publikováno v: Cell

Summary Expansion of CAG trinucleotide repeats in ATXN1 causes spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disease that impairs coordination and cognition. While ATXN1 is associated with increased Alzheimer’s disease (AD) risk, CAG re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f457763313cb758168874b6d734e73
https://pubmed.ncbi.nlm.nih.gov/31442405

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ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function

Autor: Se Hoon Choi, Andrea N. Lesinski, Jaehong Suh, Donna M. Romano, Doo Yeon Kim, Rudolph E. Tanzi, Moira A. Gannon

Publikováno v: Neuron. 80(2):385-401

SummaryThe generation of Aβ, the main component of senile plaques in Alzheimer’s disease (AD), is precluded by α-secretase cleavage within the Aβ domain of the amyloid precursor protein (APP). We identified two rare mutations (Q170H and R181G) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e81283de50b07d4f927a2bbdd8c754

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Alzheimer's Disease-Associated Ubiquilin-1 Regulates Presenilin-1 Accumulation and Aggresome Formation

Autor: Christa J. Maynard, Bradley T. Hyman, Nico P. Dantuma, Hilkka Soininen, Anne V. Thomas, Claudia Böttcher, Jayashree Viswanathan, Kaisa M.A. Kurkinen, Lars Bertram, Alice Lu, Rudolph E. Tanzi, Mikko Hiltunen, Annakaisa Haapasalo, Oksana Berezovska, Donna M. Romano, Riitta Miettinen

Publikováno v: Traffic. 12:330-348

The Alzheimer's disease (AD)-associated ubiquilin-1 regulates proteasomal degradation of proteins, including presenilin (PS). PS-dependent γ-secretase generates β-amyloid (Aβ) peptides, which excessively accumulate in AD brain. Here, we have chara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407bafe41212902ced09109ef2411626
https://doi.org/10.1111/j.1600-0854.2010.01149.x

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Amyloid-β Production Via Cleavage of Amyloid-β Protein Precursor is Modulated by Cell Density

Autor: Jesse A. Stevenson, Rudolph E. Tanzi, Yuanlin Dong, Donna M. Romano, Andrew Browne, Zhongcong Xie, Can Zhang, Jason DiVito

Publikováno v: Journal of Alzheimer's Disease. 22:683-694

Mounting evidence suggests that Alzheimer's disease (AD) is caused by the accumulation of the small peptide, amyloid-β (Aβ), a proteolytic cleavage product of amyloid-β protein precursor (AβPP). Aβ is generated through a serial cleavage of AβPP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a04f396b0094f4b6ebad38b2b8755d2
https://doi.org/10.3233/jad-2010-100816

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RNA Interference-mediated Silencing of X11α and X11β Attenuates Amyloid β-Protein Levels via Differential Effects on β-Amyloid Precursor Protein Processing

Autor: Rudolph E. Tanzi, Donna M. Romano, Zhongcong Xie

Publikováno v: Journal of Biological Chemistry. 280:15413-15421

Processing of the beta-amyloid precursor protein (APP) plays a key role in Alzheimer disease neuropathogenesis. APP is cleaved by beta- and alpha-secretase to produce APP-C99 and APP-C83, which are further cleaved by gamma-secretase to produce amyloi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5961866bee433517a16e9397df5e3f8f
https://doi.org/10.1074/jbc.m414353200

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Effects of RNAi-Mediated Silencing of PEN-2, APH-1a, and Nicastrin on Wild-Type vs FAD Mutant Forms of Presenilin 1

Autor: Zhongcong Xie, Donna M. Romano, Rudolph E. Tanzi

Publikováno v: Journal of Molecular Neuroscience. 25:067-078

The gamma-secretase complex consists of PS1/PS2, nicastrin, APH-1a, and PEN-2. PS1 undergoes endoproteolytic processing to yield two fragments: PS1-NTF and PS1-CTF. Changes in PEN-2 levels have been shown previously to affect the endoproteolytic proc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35d66f5c6af372e8ea6378a78c1b215
https://doi.org/10.1385/jmn:25:1:067

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Hypocapnia Induces Caspase-3 Activation and Increases Aβ Production

Autor: Dora M. Kovacs, Giuseppina Tesco, Rudolph E. Tanzi, Robert D. Moir, Zhongcong Xie, Donna M. Romano

Publikováno v: Neurodegenerative Diseases. 1:29-37

Background: At least half of all cases of early onset (Objective: We investigated the effects of hypocapnia, a risk factor for both cognitive and neurodevelopment deficits, on caspase-3 activation, apoptosis, and amyloid β-protein (Aβ) production,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1bac00694c5955f3a1fe8387221554
https://doi.org/10.1159/000076667

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Incremental Validity of Time Urgency and Other Type A Subcomponents in Predicting Behavioral and Health Criteria1

Autor: Heather Honig Schwenneker, Jeffrey M. Conte, Donna M. Romano, Angela F. Dew

Publikováno v: Journal of Applied Social Psychology. 31:1727-1748

Although previous studies have revealed relationships between Type A behavior pattern (TABP) measures and behavioral indexes of time urgency, such studies utilized global TABP measures that have been criticized for their lack of construct validity. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87e6cc5180b5f52ad2450ce4dde567b6
https://doi.org/10.1111/j.1559-1816.2001.tb02748.x

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Differential Effects of Apolipoprotein E Isoforms on Metal-Induced Aggregation of Aβ Using Physiological Concentrations

Autor: R. D. Moir, Rudolph E. Tanzi, Craig S. Atwood, Xudong Huang, Donna M. Romano, Jonathan D. Smith, Maxwell H. Laurans, Ashley I. Bush

Publikováno v: Biochemistry. 38:4595-4603

The epsilon 4 allele of apolipoprotein E (APOE) has been found to be a risk factor for late-onset Alzheimer's disease (AD). While the pathogenic mechanism of APOE in AD is not yet clear, APOE isoforms appear to differentially influence the aggregatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35e1a8f74c726d5b79a595cabd6afae
https://doi.org/10.1021/bi982437d

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