Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Donna M. Peters"'
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2023)
Primary open angle glaucoma (POAG) is a progressive and chronic disease exhibiting many of the features of fibrosis. The extracellular matrix (ECM) in the trabecular meshwork (TM) undergoes extensive remodeling and enhanced rigidity, resembling fibro
Externí odkaz:
https://doaj.org/article/e5a0561576c84512a19c70359bf8e918
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Integrins are a family of heterodimeric receptors composed of an α- and β-subunit that mediate cell-adhesion to a number of extracellular matrix (ECM) proteins in the Trabecular Meshwork/Schlemm’s canal (TM/SC) of the eye. Upon binding an ECM lig
Externí odkaz:
https://doaj.org/article/b1bce309f6b94fa68ee9f34b8cf280dd
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The trabecular meshwork (TM) is the tissue responsible for regulating aqueous humor fluid egress from the anterior eye. If drainage is impaired, intraocular pressure (IOP) becomes elevated, which is a primary risk factor for primary open angle glauco
Externí odkaz:
https://doaj.org/article/8048460093f44cefb57a0cd0f7694126
Publikováno v:
Cells, Vol 12, Iss 3, p 504 (2023)
Although elevated TGFβ2 levels appear to be a causative factor in glaucoma pathogenesis, little is known about how TGFβ2 expression is regulated in the trabecular meshwork (TM). Here, we investigated if activation of the cytokine regulator NFATc1 c
Externí odkaz:
https://doaj.org/article/41d56406c9ce4999bd255fd8657921f7
Autor:
Jennifer A. Faralli, Harini Desikan, Jennifer Peotter, Nitin Kanneganti, Benjamin Weinhaus, Mark S. Filla, Donna M. Peters
Publikováno v:
Molecular Vision, Vol 25, Iss 1, Pp 237-254 (2019)
Purpose: The purpose of this study is to examine the expression profile of genes related to integrin-mediated phagocytosis that are altered by dexamethasone (DEX) and/or αvβ3 integrin signaling to gain a better understanding of the molecular basis
Externí odkaz:
https://doaj.org/article/fdcc00f626fc4c24860bf77abc29ff89
Publikováno v:
Cells, Vol 10, Iss 8, p 1923 (2021)
Studies from our laboratory have suggested that activation of αvβ3 integrin-mediated signaling could contribute to the fibrotic-like changes observed in primary open angle glaucoma (POAG) and glucocorticoid-induced glaucoma. To determine how αvβ3
Externí odkaz:
https://doaj.org/article/d34ae09261224e6087659d8ff8c925bd
Publikováno v:
Stem Cells Dev
Stem cell-based therapy to restore the function of abnormal trabecular meshwork (TM) and decrease intraocular pressure (IOP) provides a novel approach to treat open-angle glaucoma. However, molecular mechanism for stem cells homing and anchoring to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3db96cfc39a455614e3755868cf7184
https://doi.org/10.1089/scd.2019.0254
https://doi.org/10.1089/scd.2019.0254
Autor:
Jennifer A. Faralli, Harini Desikan, Donna M. Peters, Jennifer L. Peotter, Mark S. Filla, Abigail C. Wannow
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Fibronectin fibrillogenesis is an integrin-mediated process that may contribute to the pathogenesis of primary open-angle glaucoma (POAG). Here, we examined the effects of αvβ3 integrins on fibrillogenesis in immortalized TM-1 cells and hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240abce67a888f857a64ac161b2ea0dd
http://europepmc.org/articles/PMC6750892
http://europepmc.org/articles/PMC6750892
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0237932 (2020)
PLoS ONE, Vol 15, Iss 8, p e0237932 (2020)
Increased deposition of fibronectin fibrils containing EDA+fibronectin by TGFβ2 is thought to be involved in the reduction of aqueous humor outflow across the trabecular meshwork (TM) of the eye and the elevation in intraocular pressure (IOP) observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cb4690bae42176ad7920c456af8ffc
http://europepmc.org/articles/PMC7444551
http://europepmc.org/articles/PMC7444551
Autor:
Colleen M. McDowell, Krishnakumar Kizhatil, Michael H. Elliott, Darryl R. Overby, Joseph van Batenburg-Sherwood, J. Cameron Millar, Markus H. Kuehn, Gulab Zode, Ted S. Acott, Michael G. Anderson, Sanjoy K. Bhattacharya, Jacques A. Bertrand, Terete Borras, Diane E. Bovenkamp, Lin Cheng, John Danias, Michael Lucio De Ieso, Yiqin Du, Jennifer A. Faralli, Rudolf Fuchshofer, Preethi S. Ganapathy, Haiyan Gong, Samuel Herberg, Humberto Hernandez, Peter Humphries, Simon W. M. John, Paul L. Kaufman, Kate E. Keller, Mary J. Kelley, Ruth A. Kelly, David Krizaj, Ajay Kumar, Brian C. Leonard, Raquel L. Lieberman, Paloma Liton, Yutao Liu, Katy C. Liu, Navita N. Lopez, Weiming Mao, Timur Mavlyutov, Fiona McDonnell, Gillian J. McLellan, Philip Mzyk, Andrews Nartey, Louis R. Pasquale, Gaurang C. Patel, Padmanabhan P. Pattabiraman, Donna M. Peters, Vijaykrishna Raghunathan, Ponugoti Vasantha Rao, Naga Rayana, Urmimala Raychaudhuri, Ester Reina-Torres, Ruiyi Ren, Douglas Rhee, Uttio Roy Chowdhury, John R. Samples, E. Griffen Samples, Najam Sharif, Joel S. Schuman, Val C. Sheffield, Cooper H. Stevenson, Avinash Soundararajan, Preeti Subramanian, Chenna Kesavulu Sugali, Yang Sun, Carol B. Toris, Karen Y. Torrejon, Amir Vahabikashi, Janice A. Vranka, Ting Wang, Colin E. Willoughby, Chen Xin, Hongmin Yun, Hao F. Zhang, Michael P. Fautsch, Ernst R. Tamm, Abbot F. Clark, C. Ross Ethier, W. Daniel Stamer
Publikováno v:
Investigative ophthalmology & visual science, vol 63, iss 2
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2366dca55a396f9cef10de74cc76d5
https://doi.org/10.1167/iovs.63.2.12
https://doi.org/10.1167/iovs.63.2.12