Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Donna M. Neumann"'
Autor:
Pankaj Singh, Matthew F. Collins, Richard N. Johns, Kayley A. Manuel, Ziyun A. Ye, David C. Bloom, Donna M. Neumann
Publikováno v:
Viruses, Vol 14, Iss 5, p 909 (2022)
HSV-1 is a human pathogen that establishes a lifelong infection in the host. HSV-1 is transported by retrograde axonal transport to sensory neurons in the peripheral nervous system where latent viral genomes can reactivate. The resulting virus travel
Externí odkaz:
https://doaj.org/article/e3f1c74ba9a34891ba7a347d1edf0339
Publikováno v:
Reviews in medical virology. 32(6)
Herpes simplex virus type 1 (HSV-1) is an important human pathogen with neurotropism. Following lytic infection in mucosal or skin epithelium, life-long latency is established mainly in sensory neurons, which can periodically reactivate by stress, le
Autor:
Esteban A. Engel, Lynn W. Enquist, Daniel W. Renner, Lance Parsons, Colleen A. Mangold, Chad V. Kuny, Jacob Shreve, Moriah L. Szpara, Donna M. Neumann
Publikováno v:
Microbiology Resource Announcements
Herpes simplex virus 1 (HSV-1) strain McKrae was isolated in 1965 and has been utilized by many laboratories. Three HSV-1 strain McKrae stocks have been sequenced previously, revealing discrepancies in key genes. We sequenced the genome of HSV-1 stra
Autor:
Pankaj, Singh, Donna M, Neumann
Publikováno v:
J Virol
Herpes simplex virus 1 (HSV-1) is a human pathogen that can establish a lifelong infection in the host. During latency, HSV-1 genomes are chromatinized and are abundantly associated with histones in sensory neurons, yet the mechanisms that govern the
Publikováno v:
J Virol
The regulatory functions of 10 individual viral microRNAs (miRNAs) that are abundantly expressed from the herpes simplex virus 1 (HSV-1) latency-associated transcript (LAT) region remain largely unknown. Here, we focus on HSV-1 miRNA miR-H8, which is
Autor:
Emilia A. H. Vanni, Donna M. Neumann, Pankaj Singh, Sanae Nakayama, David C. Bloom, Enrico R. Barrozo, Ann M. Arvin
Publikováno v:
J Virol
During all stages of infection, herpes simplex virus 1 (HSV-1) expresses viral microRNAs (miRNAs). There are at least 20 confirmed HSV-1 miRNAs, yet the roles of individual miRNAs in the context of viral infection remain largely uncharacterized. We c
Autor:
Clinton C Creech, Donna M Neumann
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15416 (2010)
Epigenetic mechanisms, via post-translational histone modifications, have roles in the establishment and maintenance of latency of the HSV-1 genome in the sensory neurons. Considering that many post-translational histone marks are reversible in natur
Externí odkaz:
https://doaj.org/article/b73eb628af4f4da39e5f6ec91df5e356
Autor:
Pankaj Singh, Donna M. Neumann
Publikováno v:
Virus Res
Glioblastoma multiforme (GBM) is the most aggressive form of primary human gliomas. While chemotherapy using the DNA alkylating agent temozolomide (TMZ) is a first line treatment for GBMs, the development of resistance to TMZ is a common limitation t
Autor:
Donna M. Neumann, Shannan D. Washington, Pankaj Singh, David C. Bloom, Seth Frietze, Richard N. Johns, Michael Mariani, Terri G. Edwards
The cellular insulator protein CTCF plays a role in herpes simplex virus 1 (HSV-1) latency through the establishment and regulation of chromatin boundaries. We previously found that the CTRL2 regulatory element downstream from the latency-associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae36ecc7d91eb74e45513c1813b0ea4
https://europepmc.org/articles/PMC6580944/
https://europepmc.org/articles/PMC6580944/
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1950
Adeno-associated Virus (AAV) vectors are useful vehicles for delivering transgenes to a number of different tissues and organs in vivo. To date, most of these applications deliver the vectors to their target by either infusion into the bloodstream or