Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Donna M. MacCallum"'
Autor:
Yasmin Ahmed, Mélanie A. C. Ikeh, Donna M. MacCallum, Alison M. Day, Kevin Waldron, Janet Quinn
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT The ability of pathogenic fungi to obtain essential nutrients from the host is vital for virulence. In Candida albicans, acquisition of the macronutrient phosphate is regulated by the Pho4 transcription factor and is important for both virul
Externí odkaz:
https://doaj.org/article/705e6bf7868e48a98baa465733475fa2
Autor:
Fiona M. Rudkin, Ingrida Raziunaite, Hillary Workman, Sosthene Essono, Rodrigo Belmonte, Donna M. MacCallum, Elizabeth M. Johnson, Lisete M. Silva, Angelina S. Palma, Ten Feizi, Allan Jensen, Lars P. Erwig, Neil A. R. Gow
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Late diagnosis and ineffective treatment of fungal infections lead to high mortality. Here, Rudkin et al. generate anti-Candida human monoclonal antibodies with diagnostic and therapeutic potential, by expressing recombinant antibodies from genes clo
Externí odkaz:
https://doaj.org/article/3962deb6cda443548deab4a2e58b1fbe
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2021)
Malassezia species are a major part of the normal mycobiota and colonize mainly sebum-rich skin regions of the body. This group of fungi cause a variety of infections such as pityriasis versicolor, folliculitis, and fungaemia. In particular, Malassez
Externí odkaz:
https://doaj.org/article/b982a19f184b429ab1c5834aec20fcc8
Autor:
Katja Schaefer, Jeanette Wagener, Ryan M. Ames, Stella Christou, Donna M. MacCallum, Steven Bates, Neil A. R. Gow
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT Amino acid metabolism is crucial for fungal growth and development. Ureohydrolases produce amines when acting on l-arginine, agmatine, and guanidinobutyrate (GB), and these enzymes generate ornithine (by arginase), putrescine (by agmatinase)
Externí odkaz:
https://doaj.org/article/a25cee59556847d1a07e1213bea9ad88
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Human skin fungal infections (SFIs) affect 25% of the world’s population. Most of these infections are superficial. The main limitation of current animal models of human superficial SFIs is that clinical presentation is different between the differ
Externí odkaz:
https://doaj.org/article/e3996e11d9f54bc7b377bd945327111c
Autor:
Lucian Duvenage, Louise A. Walker, Aleksandra Bojarczuk, Simon A. Johnston, Donna M. MacCallum, Carol A. Munro, Campbell W. Gourlay
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT The human fungal pathogen Candida albicans requires respiratory function for normal growth, morphogenesis, and virulence. Mitochondria therefore represent an enticing target for the development of new antifungal strategies. This possibility
Externí odkaz:
https://doaj.org/article/d09b6a0106be494e92b07724b0b9b1ca
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
ABSTRACT The opportunistic human fungal pathogen Candida albicans can cause a variety of diseases, ranging from superficial mucosal infections to life-threatening systemic infections. Phagocytic cells of the innate immune response, such as neutrophil
Externí odkaz:
https://doaj.org/article/5a3bcfcdec1249aba2468c48dce1a3ba
Publikováno v:
Journal of Fungi, Vol 5, Iss 2, p 29 (2019)
Traditional in vivo investigation of fungal infection and new antifungal therapies in mouse models is usually carried out using post mortem methodologies. However, biomedical imaging techniques focusing on non-invasive techniques using bioluminescent
Externí odkaz:
https://doaj.org/article/8b505579f4ca40928183310fa28b7694
Publikováno v:
Disease Models & Mechanisms, Vol 4, Iss 4, Pp 504-514 (2011)
SUMMARY Candida spp. are opportunistic pathogens in humans, and their systemic infections display upwards of 30% mortality in immunocompromised patients. Current mammalian model systems have certain disadvantages in that obtaining results is time con
Externí odkaz:
https://doaj.org/article/5ae53888b9954f61bfcc5544f3a3790a
Autor:
Mohlopheni J. Marakalala, Simon Vautier, Joanna Potrykus, Louise A. Walker, Kelly M. Shepardson, Alex Hopke, Hector M. Mora-Montes, Ann Kerrigan, Mihai G. Netea, Graeme I. Murray, Donna M. MacCallum, Robert Wheeler, Carol A. Munro, Neil A. R. Gow, Robert A. Cramer, Alistair J. P. Brown, Gordon D. Brown
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/237eac794b5c48b79e53ddc199989c63