Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Donna M. Konicek"'
Autor:
Donna M. Konicek, Adam J. Plaunt, Sachin Gharse, Sasha J. Rose, Arielle Dorfman, Amruta Sabnis, Thomas Baker, Helena Gauani, Donald Chun, Zhili Li, Walter R. Perkins, David Cipolla, Vladimir S. Malinin
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2250 (2023)
The increased prevalence of pulmonary methicillin-resistant Staphylococcus aureus (MRSA) infection in patients living with cystic fibrosis (CF) is concerning due to a correlation with reduced life expectancy and lack of available treatment options. R
Externí odkaz:
https://doaj.org/article/489479d94ae3433599532bcbf80b551d
Autor:
Richard W. Chapman, Michel R. Corboz, Carlos Fernandez, Eugene Sullivan, Andy Stautberg, Adam J. Plaunt, Donna M. Konicek, Vladimir Malinin, Zhili Li, David Cipolla, Walter Perkins
Publikováno v:
ERJ Open Research, Vol 7, Iss 1 (2021)
Cough is induced by inhaled prostacyclin analogues including treprostinil (TRE), and, at higher doses, treprostinil palmitil (TP), a prodrug of TRE. In this report, we have investigated mechanisms involved in TRE- and TP-induced cough, using a dry po
Externí odkaz:
https://doaj.org/article/190cdcb737b843978c4edc4c3898f89d
Autor:
Adam J. Plaunt, Sasha J. Rose, Jeong Yeon Kang, Kuan-Ju Chen, Daniel LaSala, Ryan P. Heckler, Arielle Dorfman, Barrett T. Smith, Donald Chun, Veronica Viramontes, Antonio Macaluso, Zhili Li, Yuchen Zhou, Lilly Mark, Jessica Basso, Franziska G. Leifer, Michel R. Corboz, Richard W. Chapman, David Cipolla, Walter R. Perkins, Vladimir S. Malinin, Donna M. Konicek
Publikováno v:
Antimicrob Agents Chemother
Chronic pulmonary methicillin-resistant Staphylococcus aureus (MRSA) disease in cystic fibrosis (CF) has a high probability of recurrence following treatment with standard-of-care antibiotics and represents an area of unmet need associated with reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7982c69e91dbbdd3bc2a38062e4560
https://europepmc.org/articles/PMC9664855/
https://europepmc.org/articles/PMC9664855/
Autor:
Walter Perkins, Richard W. Chapman, Vladimir Malinin, Michel R. Corboz, Eugene J. Sullivan, Zhili Li, David Cipolla, Adam J. Plaunt, Andy Stautberg, Donna M. Konicek, Carlos Fernandez
Publikováno v:
ERJ Open Research
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 1 (2021)
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 1 (2021)
Cough is induced by inhaled prostacyclin analogues including treprostinil (TRE), and, at higher doses, treprostinil palmitil (TP), a prodrug of TRE. In this report, we have investigated mechanisms involved in TRE- and TP-induced cough, using a dry po
Autor:
David Cipolla, Jessica Basso, Donald Chun, Lilly Mark, Vladimir Malinin, Richard W. Chapman, Daniel LaSala, Sasha J. Rose, Barrett T Smith, Zhili Li, Michel R. Corboz, Ryan P Heckler, Arielle Dorfman, Adam J. Plaunt, Yuchen Zhou, Jeong Yeon Kang, Veronica Viramontes, Antonio Macaluso, Kuan-Ju Chen, Walter Perkins, Donna M. Konicek, Franziska Leifer
Publikováno v:
Antimicrobial Agents and Chemotherapy
Chronic pulmonary methicillin-resistant Staphylococcus aureus (MRSA) disease in cystic fibrosis (CF) has a high probability of recurrence following treatment with standard-of-care antibiotics and represents an area of unmet need associated with reduc
Autor:
Richard W. Chapman, Donna M. Konicek, Adam J. Plaunt, Zhili Li, Walter Perkins, Vladimir Malinin, Michel R. Corboz
Publikováno v:
Pulmonary pharmacologytherapeutics. 65
Treprostinil (TRE) is a prostanoid analog pulmonary vasodilator drug marketed with subcutaneous, intravenous (i.v.), oral, and inhaled routes of administration for the treatment of pulmonary arterial hypertension (PAH). Due to its short half-life, TR
Autor:
Donna M. Konicek, Dany Salvail, Han Yin, Vladimir Malinin, Adam J. Plaunt, Richard W. Chapman, Charles E. Laurent, Chad Dziak, Zhili Li, Helena Gauani, Walter Perkins, Michel R. Corboz, Franziska Leifer
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 49:104-111
INS1009 is a long acting pulmonary vasodilator prodrug of treprostinil (TRE) that is formulated in a lipid nanoparticle for inhaled delivery by nebulization. This study examined the ability of INS1009 to inhibit vasoconstriction in the pulmonary vasc
Autor:
Zhili Li, Han Yin, Fadi Xu, Vladimir Malinin, Donna M. Konicek, Dany Salvail, Michel R. Corboz, Walter Perkins, Jianguo Zhuang, Franziska Leifer, Charles E. Laurent, Marzena Biernat, Aidan Curran, Kuan-Ju Chen, Richard W Chapman, Adam J. Plaunt
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 363:348-357
This article describes the preclinical pharmacology and pharmacokinetics (PK) of hexadecyl-treprostinil (C16TR), a prodrug of treprostinil (TRE), formulated in a lipid nanoparticle (LNP) for inhalation as a pulmonary vasodilator. C16TR showed no acti
Autor:
Vladimir Malinin, Charles-E. Laurent, Richard W. Chapman, Dany Salvail, Annie Bouchard, Lisa Turcotte, Zhili Li, Donna M. Konicek, Helena Gauani, Michel R. Corboz, Walter Perkins, Adam J. Plaunt, Sandra Gagnon
Publikováno v:
Pulmonary hypertension.
Introduction: Cough and airway irritation are adverse effects (AEs) associated with inhaled treprostinil (TRE). The site of action causing these AEs is unknown. Aim: Nebulized TRE, at a concentration that causes cough in guinea pigs, was administered
Autor:
Vladimir Malinin, Zhili Li, Charles E. Laurent, Walter Perkins, Kuan-Ju Chen, Michel R. Corboz, Donna M. Konicek, Adam J. Plaunt, Franziska Leifer, Dany Salvail, Richard W. Chapman
Publikováno v:
Drug research. 68(11)
Treprostinil (TRE), a prostanoid analogue approved in the USA for the treatment of pulmonary arterial hypertension, requires continuous infusion or multiple dosing sessions per day for inhaled and oral routes of administration due to its short half-l