Výsledky vyhledávání - "Donna M. Iula"

Akademický článek

Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice

Autor: Marthe M. Vandeputte, Grant C. Glatfelter, Donna Walther, Nathan K. Layle, Danielle M. St. Germaine, István Ujváry, Donna M. Iula, Michael H. Baumann, Christophe P. Stove

Publikováno v: Pharmacological Research, Vol 210, Iss , Pp 107503- (2024)

2-Benzylbenzimidazole derivatives or ‘nitazenes’ are increasingly present on the recreational drug market. Here, we report the synthesis and pharmacological characterization of 15 structurally diverse nitazenes that might be predicted to emerge o

Externí odkaz: https://doaj.org/article/1e6ec420012c427cb9ccc61ca32e7ede

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Synthesis, Chemical Characterization, and μ-Opioid Receptor Activity Assessment of the Emerging Group of 'Nitazene' 2-Benzylbenzimidazole Synthetic Opioids

Autor: Christophe P. Stove, Donna M. Iula, Katleen Van Uytfanghe, Marthe M Vandeputte, Danielle St. Germaine, Nathan Layle

Publikováno v: ACS CHEMICAL NEUROSCIENCE

Several 2-benzylbenzimidazole opioids (also referred to as "nitazenes") recently emerged on the illicit market. The most frequently encountered member, isotonitazene, has been identified in multiple fatalities since its appearance in 2019. Although r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03c4304cd28a752536f8e662f55f778
https://doi.org/10.1021/acschemneuro.1c00064

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Respiratory depressant effects of fentanyl analogs are opioid receptor-mediated

Autor: Donna M. Iula, Jonathon R. Bassman, Sherif H. Hassanien, Neil B. Varshneya, Patrick M. Beardsley, David Stevens, M.C. Holt, Nathan Layle

Publikováno v: Biochem Pharmacol

Opioid-related fatalities involving synthetic opioids have reached unprecedented levels. This study evaluated the respiratory depressant effects of seven fentanyl analogs that have either emerged in the illicit drug supply or been identified in toxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c037e33bec1702fe0076ef15d61561d
https://pubmed.ncbi.nlm.nih.gov/34673011

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Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of ‘nitazene’ 2-benzylbenzimidazole synthetic opioids

Autor: Donna M. Iula, Katleen Van Uytfanghe, Marthe M Vandeputte, Nathan Layle, Christophe P. Stove, Danielle St. Germaine

Several 2-benzylbenzimidazole opioids (also referred to as ‘nitazenes’) recently emerged on the illicit market. The most frequently encountered member, isotonitazene, has been identified in multiple fatalities since its appearance in 2019. Althou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::724fcc442d98e0f9bc8ea8dc7e5e95ac
https://doi.org/10.22541/au.160520665.59016513/v2

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Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of nitazene new synthetic opioids

Autor: Nathan Layle, Donna M. Iula, Katleen Van Uytfanghe, Christophe P. Stove, Marthe M Vandeputte, Danielle St. Germaine

Several benzimidazole opioids (commonly known as nitazenes) have recently started to emerge on the illicit market. The most frequently encountered member, the highly potent isotonitazene, has been identified in multiple fatalities since its appearanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::447faef26e83eeedd255a4894713fff3
https://doi.org/10.22541/au.160520665.59016513/v1

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Efficient syntheses of functionalized piperidines through extremely regioselective Rh-catalyzed cyclohydrocarbonylation of amido-ω,ω′-dienes

Autor: Maria Tzamarioudaki, Donna M. Iula, Iwao Ojima

Publikováno v: Tetrahedron Letters. 39:4599-4602

The highly regioselective cyclohydrocarbonylation of 4-amido-1,6-heptadienes catalyzed by Rh-BIPHEPHOS complex gives functionalized piperidines quantitatively, which serve as versatile intermediates for the syntheses of a variety of piperidine and qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36532166e8680f1fc0735718489961a3
https://doi.org/10.1016/s0040-4039(98)00848-x

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