A phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpressing breast or gastric cancer

Autor: Kerry Lynn Reynolds, Philippe L. Bedard, Se-Hoon Lee, Chia-Chi Lin, Josep Tabernero, Maria Alsina, Ezra Cohen, José Baselga, George Blumenschein, Donna M. Graham, Ignacio Garrido-Laguna, Dejan Juric, Sunil Sharma, Ravi Salgia, Abdelkader Seroutou, Xianbin Tian, Rose Fernandez, Alex Morozov, Qing Sheng, Thiruvamoor Ramkumar, Angela Zubel, Yung-Jue Bang

Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-11 (2017)

Abstract Background Human epidermal growth factor receptor 3 (HER3) is important in maintaining epidermal growth factor receptor-driven cancers and mediating resistance to targeted therapy. A phase I study of anti-HER3 monoclonal antibody LJM716 was

Externí odkaz: https://doaj.org/article/6a99ce44899c48d0b69a8d0fc67f0c5c

Bexmarilimab-induced macrophage activation leads to treatment benefit in solid tumors: the phase I/II first-in-human MATINS trial

Autor: Jenna H. Rannikko, Loic Verlingue, Maria de Miguel, Annika Pasanen, Debbie Robbrecht, Tanja Skytta, Sanna Iivanainen, Shishir Shetty, Yuk Ting Ma, Donna M. Graham, Sukeshi Patel Arora, Panu Jaakkola, Christina Yap, Yujuan Xiang, Jami Mandelin, Matti K. Karvonen, Juho Jalkanen, Sinem Karaman, Jussi P. Koivunen, Anna Minchom, Maija Hollmén, Petri Bono

Clever-1 expression in macrophages contributes to impaired antigen presentation and suppression of anti-tumor immunity. This first-in-human trial was designed to investigate the safety and tolerability of Clever-1 blockade in patients with treatment-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68b8cb2572a9a06baf7e29b63bb2c665
https://doi.org/10.1101/2023.04.17.23288693

Abstract PS12-07: Lenvatinib plus pembrolizumab for previously treated, advanced triple-negative breast cancer: Early results from the multicohort phase 2 LEAP-005 study

Autor: Seock-Ah Im, Kevin Norwood, Donna M. Graham, Hyun Cheol Chung, Esma Saada-Bouzid, Alan D. Smith, Juanita Lopez, Javier Garcia-Corbacho, Carlos Gomez-Roca, Eduardo Castanon, Eduardo Yanez, Federico Longo Muñoz, Corina E. Dutcus, Razi Ghori

Publikováno v: Cancer Research. 81:PS12-07

Background: Triple-negative breast cancer (TNBC) is associated with poor survival outcomes and treatment options are limited. These tumors lack therapeutic targets and become rapidly resistant to chemotherapy. The anti–PD-1 antibody pembrolizumab s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1c39d19e7e0f73d0e72aeba6b431dd8
https://doi.org/10.1158/1538-7445.sabcs20-ps12-07

An International Comparison of Presentation, Outcomes and CORONET Predictive Score Performance in Patients with Cancer Presenting with COVID-19 across Different Pandemic Waves

Autor: Oskar, Wysocki, Cong, Zhou, Jacobo, Rogado, Prerana, Huddar, Rohan, Shotton, Ann, Tivey, Laurence, Albiges, Angelos, Angelakas, Dirk, Arnold, Theingi, Aung, Kathryn, Banfill, Mark, Baxter, Fabrice, Barlesi, Arnaud, Bayle, Benjamin, Besse, Talvinder, Bhogal, Hayley, Boyce, Fiona, Britton, Antonio, Calles, Luis, Castelo-Branco, Ellen, Copson, Adina, Croitoru, Sourbha S, Dani, Elena, Dickens, Leonie, Eastlake, Paul, Fitzpatrick, Stephanie, Foulon, Henrik, Frederiksen, Sarju, Ganatra, Spyridon, Gennatas, Andreas, Glenthøj, Fabio, Gomes, Donna M, Graham, Christina, Hague, Kevin, Harrington, Michelle, Harrison, Laura, Horsley, Richard, Hoskins, Zoe, Hudson, Lasse H, Jakobsen, Nalinie, Joharatnam-Hogan, Sam, Khan, Umair T, Khan, Khurum, Khan, Alexandra, Lewis, Christophe, Massard, Alec, Maynard, Hayley, McKenzie, Olivier, Michielin, Anne C, Mosenthal, Berta, Obispo, Carlo, Palmieri, Rushin, Patel, George, Pentheroudakis, Solange, Peters, Kimberly, Rieger-Christ, Timothy, Robinson, Emanuela, Romano, Michael, Rowe, Marina, Sekacheva, Roseleen, Sheehan, Alexander, Stockdale, Anne, Thomas, Lance, Turtle, David, Viñal, Jamie, Weaver, Sophie, Williams, Caroline, Wilson, Caroline, Dive, Donal, Landers, Timothy, Cooksley, André, Freitas, Anne C, Armstrong, Rebecca J, Lee, On Behalf Of The Esmo Co-Care

Publikováno v: Wysocki, O, Zhou, C, Rogado, J, Huddar, P, Shotton, R, Tivey, A, Albiges, L, Angelakas, A, Arnold, D, Aung, T, Banfill, K, Baxter, M, Barlesi, F, Bayle, A, Besse, B, Bhogal, T, Boyce, H, Britton, F, Calles, A, Castelo-Branco, L, Copson, E, Croitoru, A, Dani, S S, Dickens, E, Eastlake, L, Fitzpatrick, P, Foulon, S, Frederiksen, H, Ganatra, S, Gennatas, S, Glenthøj, A, Gomes, F, Graham, D M, Hague, C, Harrington, K, Harrison, M, Horsley, L, Hoskins, R, Hudson, Z, Jakobsen, L H, Joharatnam-Hogan, N, Khan, S, Khan, U T, Khan, K, Lewis, A, Massard, C, Maynard, A, McKenzie, H, Michielin, O, Mosenthal, A C & on behalf of the ESMO Co-Care 2022, ' An International Comparison of Presentation, Outcomes and CORONET Predictive Score Performance in Patients with Cancer Presenting with COVID-19 across Different Pandemic Waves ', Cancers, vol. 14, no. 16, 3931 . https://doi.org/10.3390/cancers14163931
Cancers; Volume 14; Issue 16; Pages: 3931
Wysocki, O, Zhou, C, Rogado, J, Huddar, P, Shotton, R, Tivey, A, Albiges, L, Angelakas, A, Arnold, D, Aung, T, Banfill, K, Baxter, M, Barlesi, F, Bayle, A, Besse, B, Bhogal, T, Boyce, H, Britton, F, Calles, A, Castelo-Branco, L, Copson, E, Croitoru, A, Dani, S S, Dickens, E, Eastlake, L, Fitzpatrick, P, Foulon, S, Frederiksen, H, Ganatra, S, Gennatas, S, Glenthøj, A, Gomes, F, Graham, D M, Hague, C, Harrington, K, Harrison, M, Horsley, L, Hoskins, R, Hudson, Z, Jakobsen, L H, Joharatnam-Hogan, N, Khan, S, Khan, U T, Khan, K, Lewis, A, Massard, C, Maynard, A, McKenzie, H, Michielin, O, Mosenthal, A C, Obispo, B, Palmieri, C, Patel, R, Pentheroudakis, G, Peters, S, Rieger-Christ, K, Robinson, T, Romano, E, Rowe, M, Sekacheva, M, Sheehan, R, Stockdale, A, Thomas, A, Turtle, L, Viñal, D, Weaver, J, Williams, S, Wilson, C, Dive, C, Landers, D, Cooksley, T, Freitas, A, Armstrong, A C, Lee, R J, On Behalf Of The Esmo Co-Care & ESMO Co-Care 2022, ' An International Comparison of Presentation, Outcomes and CORONET Predictive Score Performance in Patients with Cancer Presenting with COVID-19 across Different Pandemic Waves ', Cancers, vol. 14, no. 16, 3931 . https://doi.org/10.3390/cancers14163931
Cancers
Cancers, 2022, 14 (16), ⟨10.3390/cancers14163931⟩

International audience; Simple Summary There have been huge improvements in both vaccination and the management of COVID-19 in patients with cancer. In addition, different variants may be associated with different presentations. Therefore, we examine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100b981b8270cc731ff6d6e32a47dbf1
https://curis.ku.dk/portal/da/publications/an-international-comparison-of-presentation-outcomes-and-coronet-predictive-score-performance-in-patients-with-cancer-presenting-with-covid19-across-different-pandemic-waves(d1df3857-b531-4e4a-8d70-8aaf12a781a2).html

Oncology patients’ experiences in experimental medicine cancer trials: a qualitative study

Autor: Natalie Cook, Laurie Preston, Donna M. Graham, Sally Taylor, Michelle Davies, Matthew G Krebs, Chelsea Sawyer, Louise Carter, Janelle Yorke, Fiona Thistlewaite

Publikováno v: BMJ Open
BMJ Open, Vol 11, Iss 10 (2021)
University of Manchester-PURE

ObjectivesThe study aimed to explore patients’ experiences of experimental cancer medicine (ECM) clinical trials.DesignThe study’s design was qualitative. Two focus groups with patients were undertaken followed by semistructured interviews, to ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb49f081024987c64ae437e8ee8cd587
http://europepmc.org/articles/PMC8493921