Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Donna M. Dambach"'
Autor:
Wendy B. Young, Karin Reif, Jed Ross, Jacqueline M. Tarrant, Donna M. Dambach, Karin Staflin, Adam R. Johnson, Arna Katewa, Rebecca Erickson, Maj Hedehus, Shelly Zhong, Sock-Cheng Lewin-Koh, Fiona Zhong, Lichuan Liu, Michelle McDowell, James J. Crawford, Dinah L. Misner, Richard A. D. Carano, Harvey Wong, Leah Schutt
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 360(1)
Bruton's tyrosine kinase (BTK) is a member of the Tec family of cytoplasmic tyrosine kinases involved in B-cell and myeloid cell signaling. Small molecule inhibitors of BTK are being investigated for treatment of several hematologic cancers and autoi
Autor:
Margaret M. Sleeper, Paula S. Henthorn, C. Vijayasarathy, Donna M. Dambach, Tim Bowers, Pierre Tijskens, Clara F. Armstrong, Edward B. Lankford
Publikováno v:
Journal of Veterinary Internal Medicine
Dilated cardiomyopathy recently has been recognized in juvenile Portuguese Water Dogs. The purpose of this study was to evaluate unaffected and affected puppies by physical examination, electrocardiogram (ECG), echocardiogram, specific biochemical as
Autor:
Sam T. Chao, Yufen Zhao, Katherine A. Rouleau, Zheng Yang, Henry H. Gu, Catherine A. Fleener, Zhongqi Shen, Jeffrey A. Robl, Kim W. McIntyre, Edwin J. Iwanowicz, Mark R. Witmer, Scott H. Watterson, Arvind Mathur, Bang-Chi Chen, Mary T. Obermeier, and Robert Townsend, Donna M. Dambach, T. G. Murali Dhar, Zili Xiao, Joel C. Barrish, Shelley K. Ballentine, David J. Shuster, Ping Chen
Publikováno v:
Journal of Medicinal Chemistry. 50:3730-3742
Inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the de novo synthesis of guanosine nucleotides, catalyzes the irreversible nicotinamide-adenine dinucleotide dependent oxidation of inosine-5'-monophosphate to xanthosine-5'-monophosphate.
Autor:
Donna M. Dambach
Publikováno v:
Current Topics in Medicinal Chemistry. 5:929-939
Inhibitors of p38 MAP kinases show promise for the treatment of inflammatory and immunological disorders and some cancers. There is a substantial body of experimental evidence across several organ systems suggesting that p38 also mediates development
Autor:
Yves Dubaquie, Leah-Ann Garulacan, Stanley A. Hefta, Ji Gao, Gregory J. Opiteck, Stephen M. Storm, Ashok Dongre, Donna M. Dambach
Publikováno v:
Methods. 35:291-302
Discovery of novel protein biomarkers is essential for successful drug discovery and development. These novel protein biomarkers may aid accelerated drug efficacy, response, or toxicity decision making based on their enhanced sensitivity and/or speci
Autor:
Donna M. Dambach, Paula S. Henthorn, D. F. Patterson, P. F. Jezyk, T. Meister, Margret L. Casal
Publikováno v:
Veterinary Pathology. 41:319-325
Glomerular disease was diagnosed by histopathologic examination in 11 related Bullmastiff dogs, and clinical and laboratory data were collected retrospectively. Four female and seven male dogs between the ages of 2.5 and 11 years were affected. Clini
Autor:
Donna M. Dambach, Marion K. Gordon, Stephen K. Durham, Carol R. Gardner, Mary K. Bruno, Peihong Zhou, Jeffrey D. Laskin, Donald R. Gerecke, Debra L. Laskin, Hawjyh Chiu
Publikováno v:
Toxicology and Applied Pharmacology. 192:119-130
Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the role of TNF-alpha in pro- and anti-inflammatory mediator production and liver injury induced by acetaminophen. Treatment of wild-
Autor:
Kim W. McIntyre, James R. Burke, Kathleen M. Gillooly, Pin Lu, David J. Shuster, Donna M. Dambach, Qiu Yuping, Xiadi Zhou, Mark A. Pattoli, F. Christopher Zusi
Publikováno v:
Arthritis & Rheumatism. 48:2652-2659
Objective The transcription of several cytokines, cell adhesion molecules, and enzymes involved in the inflammatory and destructive mechanisms of rheumatoid arthritis is dependent on nuclear factor κB (NF-κB). Because IκB kinase (IKK) is critical
Autor:
Steven D. Cohen, Carol R. Gardner, Stephen K. Durham, Michael Sacco, Peihong Zhou, Debra L. Laskin, Jeffrey D. Laskin, Donald R. Gerecke, Marion K. Gordon, Donna M. Dambach, Mary K. Bruno
Publikováno v:
Toxicology and Applied Pharmacology. 184:27-36
Macrophage-derived inflammatory mediators have been implicated in tissue injury induced by a number of hepatotoxicants. In the present studies, we used transgenic mice with a targeted disruption of the gene for inducible nitric oxide synthase (NOS II
Publikováno v:
Hepatology. 35:1093-1103
The biological effects of monocyte chemoattractant protein (MCP) 1 are mediated by binding to C-C chemokine receptor (CCR) 2. In the present studies, we used CCR2 knockout (CCR2-/-) mice to examine the role of MCP-1 in acetaminophen-induced macrophag