Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Donna M. Conlon"'
Autor:
Donna M. Conlon, Carolin V. Schneider, Yi-An Ko, Amrith Rodrigues, Kathy Guo, Nicholas J. Hand, Daniel J. Rader
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 6 (2022)
Genetic variants at the SORT1 locus in humans, which cause increased SORT1 expression in the liver, are significantly associated with reduced plasma levels of LDL cholesterol and apolipoprotein B (apoB). However, the role of hepatic sortilin remains
Externí odkaz:
https://doaj.org/article/0af7b8d00cb24cf5aeabcd9ab4fe24f7
Autor:
Ying Liu, Donna M. Conlon, Xin Bi, Katherine J. Slovik, Jianting Shi, Hailey I. Edelstein, John S. Millar, Ali Javaheri, Marina Cuchel, Evanthia E. Pashos, Jahangir Iqbal, M. Mahmood Hussain, Robert A. Hegele, Wenli Yang, Stephen A. Duncan, Daniel J. Rader, Edward E. Morrisey
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1456-1466 (2017)
Abetalipoproteinemia (ABL) is an inherited disorder of lipoprotein metabolism resulting from mutations in microsomal triglyceride transfer protein (MTTP). In addition to expression in the liver and intestine, MTTP is expressed in cardiomyocytes, and
Externí odkaz:
https://doaj.org/article/d7125650f9fd4644a056f52767d91fcf
Autor:
Marina Cuchel, Anna C. Raper, Donna M. Conlon, Daniel A. Pryma, Richard H. Freifelder, Rahul Poria, Debra Cromley, Xiaoyu Li, Richard L. Dunbar, Benjamin French, Liming Qu, William Farver, Ching-Chiang Su, Sissel Lund-Katz, Amanda Baer, Giacomo Ruotolo, Peter Akerblad, Carol S. Ryan, Lan Xiao, Todd G. Kirchgessner, John S. Millar, Jeffrey T. Billheimer, Daniel J. Rader
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 4, Pp 752-762 (2017)
Reverse cholesterol transport (RCT) is thought to be an atheroprotective function of HDL, and macrophage-specific RCT in mice is inversely associated with atherosclerosis. We developed a novel method using 3H-cholesterol nanoparticles to selectively
Externí odkaz:
https://doaj.org/article/50852041bbb149b0ab71cadc9ddee278
Autor:
Jorge Matias Caviglia, Constance Gayet, Tsuguhito Ota, Antonio Hernandez-Ono, Donna M. Conlon, Hongfeng Jiang, Edward A. Fisher, Henry N. Ginsberg
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 9, Pp 1636-1651 (2011)
Although short-term incubation of hepatocytes with oleic acid (OA) stimulates secretion of apolipoprotein B100 (apoB100), exposure to higher doses of OA for longer periods inhibits secretion in association with induction of endoplasmic reticulum (ER)
Externí odkaz:
https://doaj.org/article/ecd86f22b7584989a33ca87a26a4b867
Autor:
Daniel J. Rader, Donna M. Conlon, David C. Schultz, Sara Cherry, Nicholas J. Hand, Christopher Rainville, Deepti Abbey, Susannah Elwyn, Katherine Quiroz-Figueroa, Jeffrey T. Billheimer
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 4, Pp 1369-1379 (2021)
Clinical and Translational Science, Vol 14, Iss 4, Pp 1369-1379 (2021)
Hepatocytes store triglycerides (TGs) in the form of lipid droplets (LDs), which are increased in hepatosteatosis. The regulation of hepatic LDs is poorly understood and new therapies to reduce hepatosteatosis are needed. We performed a siRNA kinase
Autor:
David J. Rader, Joost P.H. Drenth, Adriaan G. Holleboom, Jos C. Jansen, J. Han M. Levels, Lars E. Larsen, Marjolein A.W. van den Boogert, Roos E. Eilers, Patrick L.E. Chong, Donna M. Conlon, Vinay Sachdev, Nicholas J. Hand, Wilson A. Rios-Ocampo, Eric S.G. Stroes, Miao He, Noam Zelcer, Tobias Raabe, Dirk Lefeber, Johan W. Jonker
Publikováno v:
Cellular and molecular gastroenterology and hepatology, 13(2), 583-597. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 583-597 (2022)
Cellular and Molecular Gastroenterology and Hepatology, 13, 583-597
Cellular and molecular gastroenterology and hepatology, 13(2), 583-597. HANLEY & BELFUS-ELSEVIER INC
Cellular and Molecular Gastroenterology and Hepatology, 13, 2, pp. 583-597
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 583-597 (2022)
Cellular and Molecular Gastroenterology and Hepatology, 13, 583-597
Cellular and molecular gastroenterology and hepatology, 13(2), 583-597. HANLEY & BELFUS-ELSEVIER INC
Cellular and Molecular Gastroenterology and Hepatology, 13, 2, pp. 583-597
Background & Aims Recently, novel inborn errors of metabolism were identified because of mutations in V-ATPase assembly factors TMEM199 and CCDC115. Patients are characterized by generalized protein glycosylation defects, hypercholesterolemia, and fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd690ee2f3528274a974978110078931
https://pure.amc.nl/en/publications/defective-lipid-dropletlysosome-interaction-causes-fatty-liver-disease-as-evidenced-by-human-mutations-in-tmem199-and-ccdc115(4a8f6f40-8c9d-48bf-9fc0-f57814f0e83b).html
https://pure.amc.nl/en/publications/defective-lipid-dropletlysosome-interaction-causes-fatty-liver-disease-as-evidenced-by-human-mutations-in-tmem199-and-ccdc115(4a8f6f40-8c9d-48bf-9fc0-f57814f0e83b).html
Autor:
Donna M. Conlon
Publikováno v:
Current Opinion in Lipidology. 30:198-204
Purpose of review Sortilin, encoded SORT1 gene at chromosome 1p13.3, is a multiligand receptor that traffics protein from the Golgi to the endosomes, secretory vesicles, and the cell surface. Genome-wide association studies (GWAS) revealed an associa
Autor:
Kim M. Olthoff, Deepti Abbey, Tobias Raabe, Daniel J. Rader, Donna M. Conlon, Katerina A.B. Gawronski, Brooke Bathon, Abraham Shaked, Sarah McCarron, Christopher D. Brown
Publikováno v:
Hepatology (Baltimore, Md.)References. 74(4)
NASH will soon become the leading cause of liver transplantation in the United States and is also associated with increased COVID-19 mortality. Currently, there are no Food and Drug Administration-approved drugs available that slow NASH progression o
Autor:
Cecilia Vitali, Donna M. Conlon, Nicholas J. Hand, Daniel J. Rader, John S. Millar, John W. Tobias, Katherine Quiroz-Figueroa, Robert C. Bauer
Publikováno v:
J Clin Invest
Genetic variants near the TRIB1 gene are highly significantly associated with plasma lipid traits and coronary artery disease. While TRIB1 is likely causal of these associations, the molecular mechanisms are not well understood. Here we sought to inv
Autor:
Richard L. Dunbar, Todd G. Kirchgessner, Rahul Poria, Donna M. Conlon, Debra Cromley, Carol S. Ryan, Marina Cuchel, Amanda Baer, Jeffrey T. Billheimer, Daniel J. Rader, Sissel Lund-Katz, Richard Freifelder, Liming Qu, Anna Raper, Giancomo Ruotolo, John S. Millar, Ching-Chiang Su, Peter Åkerblad, Benjamin French, Xiaoyu Li, William Farver, Daniel A. Pryma, Lan Xiao
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 4, Pp 752-762 (2017)
Reverse cholesterol transport (RCT) is thought to be an atheroprotective function of HDL, and macrophage-specific RCT in mice is inversely associated with atherosclerosis. We developed a novel method using 3H-cholesterol nanoparticles to selectively