Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Donna M. Barten"'
Autor:
Sethu Sankaranarayanan, Donna M Barten, Laurel Vana, Nino Devidze, Ling Yang, Gregory Cadelina, Nina Hoque, Lynn DeCarr, Stefanie Keenan, Alan Lin, Yang Cao, Bradley Snyder, Bin Zhang, Magdalena Nitla, Gregg Hirschfeld, Nestor Barrezueta, Craig Polson, Paul Wes, Vangipuram S Rangan, Angela Cacace, Charles F Albright, Jere Meredith, John Q Trojanowski, Virginia M-Y Lee, Kurt R Brunden, Michael Ahlijanian
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125614 (2015)
In Alzheimer's disease (AD), an extensive accumulation of extracellular amyloid plaques and intraneuronal tau tangles, along with neuronal loss, is evident in distinct brain regions. Staging of tau pathology by postmortem analysis of AD subjects sugg
Externí odkaz:
https://doaj.org/article/1519b91e16e24a3587dc69c274adc911
Autor:
Paul D Wes, Amy Easton, John Corradi, Donna M Barten, Nino Devidze, Lynn B DeCarr, Amy Truong, Aiqing He, Nestor X Barrezueta, Craig Polson, Clotilde Bourin, Marianne E Flynn, Stefanie Keenan, Regina Lidge, Jere Meredith, Joanne Natale, Sethu Sankaranarayanan, Greg W Cadelina, Charlie F Albright, Angela M Cacace
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e106050 (2014)
Filamentous inclusions of the microtubule-associated protein, tau, define a variety of neurodegenerative diseases known as tauopathies, including Alzheimer's disease (AD). To better understand the role of tau-mediated effects on pathophysiology and g
Externí odkaz:
https://doaj.org/article/9d297f74a7fd482c94e62f7c38c08e4e
Cerebrospinal fluid (CSF) is a complex fluid filling the ventricular system and surrounding the brain and spinal cord. Although the bulk of CSF is created by the choroid plexus, a significant fraction derives from the interstitial fluid in the brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5244bbf7c9f64c522a187533f151f3b6
https://doi.org/10.1016/b978-0-12-804279-3.00004-6
https://doi.org/10.1016/b978-0-12-804279-3.00004-6
Autor:
Andrew C. Good, Joe Shi, Catherine R. Burton, Samuel Gerritz, John E. Macor, Weixu Zhai, Shirong Zhu, Richard E. Olson, Jeremy H. Toyn, James E. Grace, Donna M. Barten, Yunhui Zhang, Jere E. Meredith, Kimberley A. Lentz, Lorin A. Thompson, Yong-Jin Wu, Charles F. Albright, Jason M. Guernon, Kenneth M. Boy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5040-5047
The synthesis, evaluation, and structure-activity relationships of a class of acyl guanidines which inhibit the BACE-1 enzyme are presented. The prolinyl acyl guanidine chemotype (7c), unlike compounds of the parent isothiazole chemotype (1), yielded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b930dff1463e1d5670f3e942574f4e4b
https://doi.org/10.1016/j.bmcl.2015.10.031
https://doi.org/10.1016/j.bmcl.2015.10.031
Publikováno v:
Handbook of clinical neurology. 146
Cerebrospinal fluid (CSF) is a complex fluid filling the ventricular system and surrounding the brain and spinal cord. Although the bulk of CSF is created by the choroid plexus, a significant fraction derives from the interstitial fluid in the brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9dc5b364f7dd85b928463dc271e4a1d
https://pubmed.ncbi.nlm.nih.gov/29110779
https://pubmed.ncbi.nlm.nih.gov/29110779
Autor:
C. Fessler, S.-H. Kim, Christopher Janus, L. Yang, G. Gray, T. Riff, Nina Hoque, Cathy A. Andorfer, Richard E. Olson, P. Y. A. Wong, J. Protassio, L. B. DeCarr, V. Liu, Sethu Sankaranarayanan, F. Y. Lee, Donna M. Barten, J. E. Meredith, G. W. Cadelina, Amanda Hanna, C. Polson, G. D. Vite, H. Turner, Charles F. Albright, Kristofor H. Husted, Patrizia Fanara
Publikováno v:
The Journal of Neuroscience. 32:7137-7145
Tau is a microtubule (MT)-stabilizing protein that is altered in Alzheimer's disease (AD) and other tauopathies. It is hypothesized that the hyperphosphorylated, conformationally altered, and multimeric forms of tau lead to a disruption of MT stabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48497ab202ecf661faaee61228f2327e
https://doi.org/10.1523/jneurosci.0188-12.2012
https://doi.org/10.1523/jneurosci.0188-12.2012
Autor:
Bergstrom Carl P, Jeremy H. Toyn, Robert H. Grafstrom, Yang Michael G, Mcelhone Katharine E, Michael J. Ford, Cathy J. Kieras, Yang Cao, Dietmar A. Seiffert, Richard E. Olson, Lawrence G. Iben, Charles F. Albright, Joseph L. Cantone, Craig Polson, Maria Pierdomenico, Jason A. Corsa, Dieter M. Drexler, John E. Macor, Jere E. Meredith, Margi E. Goldstein, Lisa M. Sisk, Mark W. Thompson, Joanne J. Bronson, Arthur H. Roach, Catherine R. Burton, Tracey Fiedler, Carol M. Krause, Robert Zaczek, Yuval Blat, Donna M. Barten, Andrew M. Stern, Xu-Alan Lin
Publikováno v:
Journal of Biological Chemistry. 283:22992-23003
The amyloid-beta (Abeta) peptide, which likely plays a key role in Alzheimer disease, is derived from the amyloid-beta precursor protein (APP) through consecutive proteolytic cleavages by beta-site APP-cleaving enzyme and gamma-secretase. Unexpectedl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efba80ada17865ffd18096d0a9820ce3
https://doi.org/10.1074/jbc.m804175200
https://doi.org/10.1074/jbc.m804175200
Autor:
Charles F. Albright, Donna M. Barten
Publikováno v:
Molecular Neurobiology. 37:171-186
Therapeutic approaches for Alzheimer's disease (AD) are guided by four disease characteristics: amyloid plaques, neurofibrillar tangles (NFT), neurodegeneration, and dementia. Amyloid plaques are composed largely of 4 kDa beta-amyloid (Abeta) peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::decd578783701901957aa56fa8878021
https://doi.org/10.1007/s12035-008-8031-2
https://doi.org/10.1007/s12035-008-8031-2
Autor:
Kevin M. Felsenstein, Joanne J. Bronson, C.V.C. Prasad, Graham Johnson, Donna M. Barten, Michael F. Parker, Jason A. Corsa, Jeremy Mock, Valerie Guss, David W. Smith, Charles P. Sloan, Williams Andrew, Owen Brendan Wallace, Steven Hansel, Craig Polson, Keavy Daniel J, Milind Deshpande, Bergstrom Carl P, Henry H. Wang, Wai Y. Lau, Ming Zheng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4432-4436
A series of N-alkylbenzenesulfonamides were developed from a high throughput screening hit. Classic and parallel synthesis strategies were employed to produce compounds with good in vitro and in vivo gamma-secretase activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4e4c718d573bc4fecf0106868fda33
https://doi.org/10.1016/j.bmcl.2007.06.022
https://doi.org/10.1016/j.bmcl.2007.06.022
Autor:
Barbara J. Robertson, Ming Zheng, Alice Loo, Jian Wang, Jason A. Corsa, David W. Smith, Susan B. Roberts, Shikha Vig, Joseph P. Hendrick, Qi Gao, Suresh Yeola, Bogdan Sleczka, Craig Polson, Donna M. Barten, Valerie Guss, Bergstrom Carl P, Charles Dangler, C.V.C. Prasad
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4006-4011
We report on the design of benzodiazepinones as peptidomimetics at the carboxy terminus of hydroxyamides. Structure-activity relationships of diazepinones were investigated and orally active gamma-secretase inhibitors were synthesized. Active metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4d0a33cbe474cfe171b1d9a76a1715
https://doi.org/10.1016/j.bmcl.2007.04.082
https://doi.org/10.1016/j.bmcl.2007.04.082