Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Donna Lombardi"'
Autor:
William G. Couser, James A. Bassuk, Raimund Pichler, Richard J. Johnson, Kathy Gordon, Jeffrey Pippen, Justin D. Rothmier, Rick L. Meek, May J. Reed, Donna Lombardi, E. Helene Sage, Amy D. Bradshaw, Thomas P. Strandjord
Publikováno v:
Kidney International. 57:117-128
Induction of TGF-β1 by the matricellular protein SPARC in a rat model of glomerulonephritis.BackgroundSPARC has been implicated as a counteradhesive and antiproliferative protein associated with deposits of extracellular matrix in renal disease.Meth
Autor:
Stephen M. Schwartz, Patti Polinsky, Richard J. Johnson, Donna Lombardi, Shinichi Suga, Katherine L. Gordon
Publikováno v:
Hypertension. 33:1013-1019
Abstract —We hypothesized that short-term exposure to angiotensin II (Ang II) could result in structural and functional changes in the kidney that would favor sodium retention and the development of sustained hypertension. To test this hypothesis,
Publikováno v:
American Journal of Hypertension. 11:954-961
A role has recently been proposed for the tubulointerstitium in the pathogenesis of salt-dependent essential hypertension. In this study, biopsies from patients with essential hypertension with either minimal ("benign") or severe ("decompensated") tu
Autor:
Enming J. Su, Michael A. Reidy, Joseph Wiener, Donna Lombardi, Stephen M. Schwartz, Mat J.A.P. Daemen
Publikováno v:
Circulation Research. 82:321-327
Abstract —In this study, anti–basic fibroblast growth factor (anti-bFGF) antibody was used to determine whether the mitogenic effect of angiotensin II in vivo could be blocked by neutralizing bFGF in the vessel wall. Animals, divided into six exp
Autor:
Donna Lombardi, Denis deBlois, Manuela Almeida, Lucy Liaw, Stephen M. Schwartz, Cecilia M. Giachelli
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 17:188-193
Osteopontin is an arginine-glycine-aspartate-containing acidic glycoprotein with adhesive and migratory activities in vitro. We previously showed that osteopontin was highly expressed in injured rat arteries as well as in human atherosclerotic plaque
Autor:
Takeshi F. Andoh, Stephen M. Schwartz, William M. Bennett, James A. Bassuk, William G. Couser, Christian Hugo, Charles E. Alpers, Richard J. Johnson, E. Helene Sage, Donna Lombardi, Stuart J. Shankland, May J. Reed, Raimund Pichler
Publikováno v:
Kidney International. 50(6):1978-1989
SPARC is expressed in renal interstitial fibrosis and in renal vascular injury. Tubulointerstitial inflammation and fibrosis are critical determinants for renal function and prognosis in a variety of human nephropathies. Yet, the pathophysiology of t
Autor:
Enming J. Su, Cecilia M. Giachelli, Donna Lombardi, Denis deBlois, Alexander W. Clowes, Stephen M. Schwartz
Publikováno v:
Hypertension. 28:1055-1063
We recently identified the adhesive protein osteopontin as a novel smooth muscle cell product overexpressed in rat developing neointima and human atheroma. Although osteopontin is a candidate stimulant for intimal lesion progression because of its ch
Autor:
Denis deBlois, E.M. van Kleef, A.K. Bidani, Stephen M. Schwartz, M.J.A.P. Daemen, J.E. Su, Donna Lombardi, K.A. Griffin
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology, 16(9), 1122-1129. Lippincott Williams and Wilkins
Despite indirect evidence from studies using adrenergic antagonists or sympathectomy, catecholamines have never been shown directly to stimulate vascular smooth muscle cell (SMC) DNA replication in vivo. We studied whether a chronic infusion of catec
Autor:
Donna Lombardi, Jürgen Floege, Katherine L. Gordon, Bessie A. Young, Pamela Pritzl, Richard J. Johnson, Jeffrey W. Pippin, Charles E. Alpers, William G. Couser, Giulio Gabbiani, Eudora Eng
Publikováno v:
Kidney International. 47:62-69
Modulation of experimental mesangial proliferative nephritis by interferon-γ. The observation that interferon-γ (IFN-γ) inhibits cell proliferation and collagen synthesis of a variety of cell types in culture has suggested that IFN-γ may be usefu
Publikováno v:
Biochemical and Biophysical Research Communications. 177:867-873
We have identified a rat smooth muscle cell mRNA, 2B7, which distinguishes smooth muscle cell phenotypes in vitro. Sequence and tissue distribution data strongly suggest this mRNA to be identical to osteopontin (secreted phosphoprotein I, 2aR). In vi