Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Donna Lee Regl"'
Autor:
Murray D. Norris, Michelle Haber, Donna Lee Regl, Dennis Yi-Shin Kuo, Maria Kavallaris, Catherine Burkhart, Susan Band Horwitz
Publikováno v:
Journal of Clinical Investigation. 100:1282-1293
The treatment of advanced ovarian cancer with taxol is hindered by the development of drug resistance. The cellular target for taxol is the microtubule that is stabilized by the drug. Taxol preferentially binds to the beta subunit of tubulin of which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73553c6055903e7043660ce9fb9d60b5
https://doi.org/10.1172/jci119642
https://doi.org/10.1172/jci119642
Autor:
Avi I. Einzig, Susan Band Horwitz, Yuexian Wang, Kevin P. O'Boyle, Janice P. Dutcher, Edward L. Schwartz, Donna Lee Regl, Peter H. Wiernik
Publikováno v:
Cancer. 79:1022-1030
BACKGROUND Paclitaxel is an antimitotic agent isolated from the Pacific yew tree. It has demonstrated antitumor activity in several cancers and is the first of a new class of antineoplastic agents containing a taxane ring system. Its levels in serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d77d76a132d02aaf3b02359284b761e
https://doi.org/10.1002/(sici)1097-0142(19970301)79:5<1022::aid-cncr20>3.0.co
https://doi.org/10.1002/(sici)1097-0142(19970301)79:5<1022::aid-cncr20>3.0.co
Autor:
Catherine Burkhart, Murray D. Norris, Janice Madafiglio, Donna Lee Regl, Susan Band Horwitz, Michelle Haber
Publikováno v:
Journal of Biological Chemistry. 270:31269-31275
A series of taxol- and taxotere-resistant J774.2 cell lines has been characterized with respect to altered expression of beta-tubulin, the cellular target for these drugs. Vertebrates have six classes of beta-tubulin isotypes, each displaying a disti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ca1b492c28e25dde899eae2a92585f
https://doi.org/10.1074/jbc.270.52.31269
https://doi.org/10.1074/jbc.270.52.31269