Výsledky vyhledávání - "Donna L. Topping"

Patient-centric care in bladder cancer: Virtual simulation to benefit clinical decision-making of oncologists

Autor: Emily Sherene Van Laar, Donna L. Topping, Saee Dhoble, Kinjal Parikh, Haleh Kadkhoda, Patrick Kugel, Jacob Cohen

Publikováno v: Journal of Clinical Oncology. 39:492-492

492 Background: Immunotherapy (IO) utility in bladder cancer (UC) has expanded into multiple stages of disease. Employing IO optimally requires mastery of clinical trial data, patient eligibility criteria, and interpretation of biomarkers and determi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42e945893ceb4567ea11729a1a120c53
https://doi.org/10.1200/jco.2021.39.6_suppl.492

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Abstract 2040: Virtual patient simulation improves first-line treatment selection in advanced EGFR-mutated NSCLC

Autor: Rich Caracio, Michelle A. Worst, Donna L. Topping, Suresh S. Ramalingam

Publikováno v: Cancer Research. 80:2040-2040

Background: Patients with advanced EGFR-mutated NSCLC benefit from treatment with EGFR TKIs. However, gaps in oncologists' performance hamper their ability to integrate individualized treatments into the care of patients with this disease. This study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d1089d602c7c964002e6b638e1750a4
https://doi.org/10.1158/1538-7445.am2020-2040

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Early Stage HER2-Positive Breast Cancers Not Achieving a pCR From Neoadjuvant Trastuzumab- or Pertuzumab-Based Regimens Have an Immunosuppressive Phenotype

Autor: Smita K. Nair, P. Kelly Marcom, Kimberly L. Blackwell, Terry Hyslop, Lynn Howie, Gloria Broadwater, Sara Abbott, Donna L. Topping, Jeremy Force, Michelle Parks, Kelly Westbrook, Gretchen Kimmick, Rex C. Bentley, Sarah Sammons, Ryan O. Emerson

Publikováno v: Clinical breast cancer. 18(5)

Background Stromal tumor-infiltrating lymphocytes (TILs) might predict pathologic complete response (pCR) in patients with HER2-positive (HER2+) breast cancer treated with trastuzumab (H). Docetaxel (T), carboplatin (C), H, and pertuzumab (P) have im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebd0910f2e229d2180ad4aa1b9a0dbf
https://pubmed.ncbi.nlm.nih.gov/29615305

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Increased FoxP3 and PD-L1 in non-pCR tissue from early stage HER2 positive breast cancer patients treated with trastuzumab-pertuzumab based regimens

Autor: Kimberly L. Blackwell, Lynn Howie, Rex C. Bentley, Smita K. Nair, Sara Abbott, Gloria Broadwater, Kelly E. Westbrook, Michelle Parks, Donna L. Topping, Paul K. Marcom, Jeremy Force, Gretchen Kimmick

Publikováno v: Journal of Clinical Oncology. 34:602-602

602Background: Increased stromal tumor infiltrating lymphocytes (STILs) may predict for pathologic complete response (pCR) in HER2+ breast cancer patients treated with neoadjuvant trastuzumab (H). Taxanes (T) and carboplatin (C) have immune modulatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a4120c27f154b3ab8d588ca34d711dd
https://doi.org/10.1200/jco.2016.34.15_suppl.602

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Clinical impact of febrile neutropenia (FN) increase among patients receiving adjuvant docetaxel/cyclophosphamide (TC) chemotherapy compared to TC plus pegfilgrastim for breast cancer

Autor: Donna L. Topping, Erika Hamilton, Gretchen Kimmick, C. Cirrincione, Jeffrey Peppercorn, Kimberly L. Blackwell, Erin Duff, P. Kelly Marcom

Publikováno v: Journal of Clinical Oncology. 31:1076-1076

1076 Background: The FN rate for the approved regimen of TC is 5% in pivotal studies. Other small retrospective reports have reported FN rates as high as 20-35%. We report the incidence of FN from a large retrospective series of breast cancer patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99e1b269729c930cda349d852a3f3d9f
https://doi.org/10.1200/jco.2013.31.15_suppl.1076

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