Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Donna L. McPhie"'
Abnormalities of brain connectivity are consistently observed in individuals with schizophrenias (SZ). Underlying these anomalies, convergent in vivo, post-mortem, and genomic evidence suggest abnormal oligodendrocyte (OL) development and function, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d8a519b0701fe1e1250e010ee14ce31
https://doi.org/10.1101/2022.06.14.496174
https://doi.org/10.1101/2022.06.14.496174
Autor:
Donna L. McPhie, Hae-Young Kim, Gun-Hoo Park, Peiyan Ni, Yiren Qin, Sangmi Chung, Joseph T. Coyle, Zhicheng Shao, Derek T Le, James M. Park, Haneul Noh, Chiderah P Abani, Weihua Huang, Hualin S. Xi, Dongxin Liu, Changhong Yin, Joy S. Park, Cameron P Beaudreault, Bruce M. Cohen, Sasha Z Gonzalez, Thomas A. Lanz, Youxin Guan
Publikováno v:
Nature neuroscience
The mechanisms by which prenatal immune activation increase the risk for neuropsychiatric disorders are unclear. Here, we generated developmental cortical interneurons (cINs)-which are known to be affected in schizophrenia (SCZ) when matured-from ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60491010134cd182aa1478ad63dcbfcf
https://doi.org/10.1038/s41593-020-00724-1
https://doi.org/10.1038/s41593-020-00724-1
Autor:
Anne M. Bara, Dane Z. Hazelbaker, Ellen J. Guss, Roy H. Perlis, Mitja I. Kurki, Steven E. Hyman, Aarno Palotie, Ralda Nehme, Aditi Trehan, Rolf Adolfsson, Mykyta Artomov, Bruce M. Cohen, Christina Lilliehook, Amanda Beccard, Emanuela Zuccaro, Mark J. Daly, Rhea Malik, Joao A. Paulo, Wade Harper, Lindy E. Barrett, Danielle Manning, Christina Bell, Jon M. Madison, Neale Bm, Donna L. McPhie, Olli Pietilainen, Derek Hawes, Kevin Eggan, Anna Neumann, Matthew Tegtmeyer, John D. Sherwood, Emily Peirent, Andrea Ganna, Vera Valakh, Eija Hämäläinen, Christina M. Hultman, Anna K. Kähler, Alexander A. Loboda, Samouil L. Farhi, Tarjinder Singh, Steven A. McCarroll, Giulio Genovese, Ricardo E. Dolmetsch, Outi Kuismin
To study how the 22q11.2 deletion predisposes to psychiatric disease, we generated induced pluripotent stem cells from deletion carriers and controls, as well as utilized CRISPR/Cas9 to introduce the heterozygous deletion into a control cell line. Up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0442f49e59d92961d15445baa72af0af
https://doi.org/10.1101/2021.09.22.461360
https://doi.org/10.1101/2021.09.22.461360
Autor:
Antonia L Dow, Tiffany V Lin, Elena H Chartoff, David Potter, Donna L McPhie, Ashlee V Van't Veer, Allison T Knoll, Kristen N Lee, Rachael L Neve, Tarun B Patel, Dost Ongur, Bruce M Cohen, William A Carlezon
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120693 (2015)
Both the development and relief of stress-related psychiatric conditions such as major depression (MD) and post-traumatic stress disorder (PTSD) have been linked to neuroplastic changes in the brain. One such change involves the birth of new neurons
Externí odkaz:
https://doaj.org/article/fdc7b7c3b91f4cca82e12fe6c3b536f8
Autor:
Roy H. Perlis, Hualin Simon Xi, Leonard M. Eisenberg, Sangmi Chung, Alexander A. Moghadam, Donna L. McPhie, Bruce M. Cohen, Weihua Huang, Woong Bin Kim, Patric K. Stanton, Changhong Yin, Sarah E. Cote, Teruyoshi Hirayama, Joyce Zhao, Judith L. Rapoport, Emi Fukuda, Takeshi Yagi, Kevin Eggan, Elizabeth Noyes, Sulagna Ghosh, Dost Öngür, James M. Park, Daniel R. Weinberger, Teagan Parsons, Kelvin Zheng, Joshua J. Park, Thomas A. Lanz, Karen F. Berman, Jun-Hyeong Cho, Christine T. O. Nguyen, Haneul Noh, Hae Young Kim, Joseph T. Coyle, Jose A. Apud, Peiyan Ni, Richard E. Straub, Zhicheng Shao
Publikováno v:
Nature Neuroscience. 22:229-242
We generated cortical interneurons (cINs) from induced pluripotent stem cells derived from 14 healthy controls and 14 subjects with schizophrenia. Both healthy control cINs and schizophrenia cINs were authentic, fired spontaneously, received function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a3fa6f1d2c4973104c94c13c8290d4c
https://doi.org/10.1038/s41593-018-0313-z
https://doi.org/10.1038/s41593-018-0313-z
Autor:
Kara Lopez-Lengowski, Bruce M. Cohen, Rakesh Karmacharya, Annie Kathuria, Magdalena Vater, Donna L. McPhie
Publikováno v:
Genome Medicine
Genome Medicine, Vol 12, Iss 1, Pp 1-16 (2020)
Genome Medicine, Vol 12, Iss 1, Pp 1-16 (2020)
Background Reprogramming human induced pluripotent stem cells (iPSCs) from somatic cells and generating three-dimensional brain organoids from these iPSCs provide access to live human neuronal tissue with disease-specific genetic backgrounds. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1528f93488ac2911af6327f678550c
http://europepmc.org/articles/PMC7168850
http://europepmc.org/articles/PMC7168850
Autor:
Kara Lopez-Lengowski, Bradley Watmuff, Bruce M. Cohen, Annie Kathuria, Donna L. McPhie, Rakesh Karmacharya
Publikováno v:
Biological Psychiatry. 89:S33-S34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40bbc0fc8b57d99fe0cba6cfd7fbc4fa
https://doi.org/10.1016/j.biopsych.2021.02.102
https://doi.org/10.1016/j.biopsych.2021.02.102
Autor:
Eyal Asor, Hila Ene, Ofer Ytzhaki, Ina Weiner, Robicsek O, Bruce M. Cohen, Donna L. McPhie, Rachel Karry, Dorit Ben-Shachar, Rotem Ben-Yehuda
Publikováno v:
Schizophrenia Bulletin. 44:432-442
Dysfunction of mitochondria, key players in various essential cell processes, has been repeatedly reported in schizophrenia (SZ). Recently, several studies have reported functional recovery and cellular viability following mitochondrial transplantati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972342da02d86ca184d0afea25700b82
https://doi.org/10.1093/schbul/sbx077
https://doi.org/10.1093/schbul/sbx077
Autor:
Rakesh Karmacharya, Donna L. McPhie, Bradley Watmuff, Bruce M. Cohen, Annie Kathuria, Kara Lopez-Lengowski
Publikováno v:
Translational Psychiatry, Vol 9, Iss 1, Pp 1-13 (2019)
Translational Psychiatry
Translational Psychiatry
Human postmortem studies suggest a major role for abnormalities in GABAergic interneurons in the prefrontal cortex in schizophrenia. Cortical interneurons differentiated from induced pluripotent stem cells (iPSCs) of schizophrenia subjects showed sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4d4b2199274657cbe987df799942b8
https://doi.org/10.1038/s41398-019-0660-x
https://doi.org/10.1038/s41398-019-0660-x
Autor:
Rakesh Karmacharya, Hyoungjun Park, Bradley Watmuff, Dost Öngür, Clary B. Clish, Bruce M. Cohen, Shaunna S. Berkovitch, Joanne H. Huang, Donna L. McPhie, Jonathan Iaconelli
Publikováno v:
Journal of Proteome Research. 16:481-493
We undertook an unbiased metabolite profiling of fibroblasts from schizophrenia patients and healthy controls to identify metabolites and pathways that are dysregulated in disease, seeking to gain new insights into the disease biology of schizophreni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c64fc3dc157be815d17a0720d30d46
https://doi.org/10.1021/acs.jproteome.6b00628
https://doi.org/10.1021/acs.jproteome.6b00628