Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Donna L. Himes"'
Publikováno v:
Acta Oto-Laryngologica. 80:86-92
Permanent cochlear damage has been shown to occur in guinea pigs following the combined administration of kanamycin and furosemide. At the doses used, only a transient effect was measured with furosemide alone and no effect was detectable with kanamy
Publikováno v:
Acta Oto-Laryngologica. 93:211-217
The ototoxic interaction between the aminoglycoside antibiotics (streptomycin, kanamycin, etc.) and the loop-inhibiting diuretics (ethacrynic acid, furosemide and bumetanide) has been well documented. This interaction causes extensive destruction of
Publikováno v:
Journal of Antimicrobial Chemotherapy. 4:73-83
Publikováno v:
Journal of Antimicrobial Chemotherapy. 14:291-302
Kanamycin was administered in total daily doses of 0 (vehicle), 100, 200 or 300 mg/kg to different groups of guinea pigs for two weeks. These total daily doses were administered according to three different dosing schedules, either as a single inject
Publikováno v:
Archives of Otolaryngology - Head and Neck Surgery. 98:297-301
Sodium salicylate was shown to have no effect on the alternating current cochlear potential and to reduce the neural evoked potential. This effect is reversible. It is postulated that sodium salicylate does not affect the hair cells of the cochlea bu
Publikováno v:
Archives of Otolaryngology - Head and Neck Surgery. 105:240-246
• We determined the range of doses of kanamycin sulfate and ethacrynic acid that results in an ototoxic interaction in guinea pigs. In addition, we determined the time interval between the administration of the two drugs that is needed to produce t
Publikováno v:
Archives of Otolaryngology - Head and Neck Surgery. 104:579-584
• Netilmicin sulfate is a new aminoglycoside antibiotic currently undergoing clinical investigation. All of the aminoglycoside antibiotics now in clinical use are ototoxic. This study was done to determine the ototoxic liability of netilmicin when
Publikováno v:
The Journal of Clinical Pharmacology. 21:628-636
The ototoxicity of bumetanide and furosemide was compared in Topeka strain guinea pigs pretreated with kanamycin. The animals, anesthetized with pentobarbital, received a single dose of 400 mg/kg kanamycin subcutaneously and the diuretics via indwell
Publikováno v:
Archives of otolaryngology (Chicago, Ill. : 1960). 98(1)
The clinical observation that ethacrynic acid administration to patients receiving kanamycin therapy can result in a permanent hearing loss has been verified in experimental animals. We have demonstrated that guinea pigs receiving a loading dose of 4
Publikováno v:
Archives of otolaryngology (Chicago, Ill. : 1960). 96(6)
Dose response experiments were conducted on guinea pigs comparing the toxic liability of tobramycin and gentamicin on cochlear electrophysiology and histology. Parallel curves were obtained for the effect on the alternating current cochlear potential