Výsledky vyhledávání - "Donna L. George"

Akademický článek

African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

Autor: Kumar Sachin Singh, Julia I-Ju Leu, Thibaut Barnoud, Prashanthi Vonteddu, Keerthana Gnanapradeepan, Cindy Lin, Qin Liu, James C. Barton, Andrew V. Kossenkov, Donna L. George, Maureen E. Murphy, Farokh Dotiwala

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

A polymorphism in human TP53 (P47S) that predominantly exists in individuals of African descent affects ferroptosis. Here, the authors show that this results in iron accumulation in macrophages leading to more productive infection by intracellular ba

Externí odkaz: https://doaj.org/article/2d5a574431c94fcbb245e3571e64248d

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Akademický článek

P53 regulates cellular redox state, ferroptosis and metabolism

Autor: Julia I-Ju Leu, Maureen E. Murphy, Donna L. George

Publikováno v: Molecular & Cellular Oncology, Vol 8, Iss 2 (2021)

The tumor protein P53 (TP53, or p53) has complex and at times seemingly contradictory roles in the regulation of metabolism and ferroptosis sensitivity. We find that the actions of p53 influence the redox state, which can trigger changes in redox-sen

Externí odkaz: https://doaj.org/article/d59e66c600164c3ab3a02c6616a35f21

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Akademický článek

The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction

Autor: Che-Pei Kung, Julia I-Ju Leu, Subhasree Basu, Sakina Khaku, Frederick Anokye-Danso, Qin Liu, Donna L. George, Rexford S. Ahima, Maureen E. Murphy

Publikováno v: Cell Reports, Vol 14, Iss 10, Pp 2413-2425 (2016)

p53 is well known for its tumor suppressor role, but this protein also has a poorly understood role in the regulation of metabolism. Human studies have implicated a common polymorphism at codon 72 of p53 in diabetic and pre-diabetic phenotypes. To un

Externí odkaz: https://doaj.org/article/cd66e87c89924d80898655f20d639f64

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Akademický článek

Author Correction: African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Externí odkaz: https://doaj.org/article/159f3b88f2f24dd4a8580af0f628aa6a

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Akademický článek

Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

Autor: Keerthana Gnanapradeepan, Julia I-Ju Leu, Subhasree Basu, Thibaut Barnoud, Madeline Good, Joyce V Lee, William J Quinn, Che-Pei Kung, Rexford Ahima, Joseph A Baur, Kathryn E Wellen, Qin Liu, Zachary T Schug, Donna L George, Maureen E Murphy

Publikováno v: eLife, Vol 9 (2020)

The Pro47Ser variant of p53 (S47) exists in African-descent populations and is associated with increased cancer risk in humans and mice. Due to impaired repression of the cystine importer Slc7a11, S47 cells show increased glutathione (GSH) accumulati

Externí odkaz: https://doaj.org/article/c17ed4ebd0124f678260df2ab091b171

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Supplementary Figure 1 from A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent

Autor: Maureen E. Murphy, Donna L. George, Tim Yen, Roland L. Dunbrack, Jessie Villanueva, Meenhard Herlyn, Gao Zhang, Mark D. Andrake, Seth Hayik, Neil Beeharry, Julia I.-Ju Leu, Gregor M. Balaburski

PDF file - 130K, A) Chemical structure of biotinylated PES B) Chemical structure of PES and derivatives NSC85560, NSC166772 and NSC303578 (nomenclature is from the National Cancer Institute Drug Repository). C) Cell viability of H1299 and PANC1 cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de7b1efb4cbb6c7db23a51d94ef5d0a
https://doi.org/10.1158/1541-7786.22509972

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Supplementary Figure 3 from A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent

PDF file - 395K, A) Binding assays of H1299 cells transfected with HA-tagged full-length and truncated HSP70 encoding the amino acids (aa) shown, treated with 20 uM biotinylated PES (B-PES) and 20 uM PES-Cl (PES-Cl). Biotinylated PES complexes were p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aba85d6b3700b8dbb389e243757e4bf
https://doi.org/10.1158/1541-7786.22509963

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Data from A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent

The stress-induced HSP70 is an ATP-dependent molecular chaperone that plays a key role in refolding misfolded proteins and promoting cell survival following stress. HSP70 is marginally expressed in nontransformed cells, but is greatly overexpressed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5831e01dfb9f964d953582a0c6090e8
https://doi.org/10.1158/1541-7786.c.6539460

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Supplementary Figure 2 from A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent

PDF file - 280K, A) Chemical structures of PES and synthesized derivatives. P=pyrrolidine; CM= carboxymethyl; Cl=chloride. B) MTT cell viability analyses of H1299 and PANC1 cells after 48 hour treatment with 10 uM PES, PES-P, PES-PCM and PES-PCl. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334adae23d57fa2d3e4615c521390d4e
https://doi.org/10.1158/1541-7786.22509969.v1

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