Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Donna L. Dehn"'
Autor:
Andrea Di Francesco, Donald S. Backos, David Ross, Nichole Reisdorph, David Siegel, Donna L. Dehn, Kevin Quinn, Michel Bernier, Rafael de Cabo
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bef1ec58b67d95eb2e8e2f47acb39b71
https://doi.org/10.1096/fasebj.2018.32.1_supplement.533.93
https://doi.org/10.1096/fasebj.2018.32.1_supplement.533.93
Autor:
Loretta Gaido, Donna L. Dehn, Petra Homer, Chesney Thompson, Kenneth R. Shroyer, Panduka Samarawardana, Kathleen C. Torkko, Meenakshi Singh, Douglas Franquemont, Vipul Nayi, Stephanie Burke, Matthew A. Titmus
Publikováno v:
Cancer Cytopathology. 118:146-156
BACKGROUND The primary goal of this study was to compare the clinical performance of an optimized and rigorously controlled immunocytochemical (ICC) assay for p16INK4a to high-risk (HR) human papillomavirus (HPV) detection by polymerase chain reactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3d116a0ed6865d4342cb7c0c3c197a
https://doi.org/10.1002/cncy.20078
https://doi.org/10.1002/cncy.20078
Autor:
Donna L. Dehn, T. Miyatake, Barbara Tringler, Jackie Papkoff, Takayuki Enomoto, Ashanta Swisher, Shu-Hui Liu, Kathleen C. Torkko, Kenneth R. Shroyer, Wenhui Liu
Publikováno v:
Gynecologic Oncology. 106:119-127
Objectives and methods B7-H4 (DD-O110), a member of the B7 family, negatively regulates T cell-mediated immune response. Previous studies have shown that B7-H4 is highly expressed in endometrioid ovarian cancers with relatively low levels of expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9774f32264aed54f2e85d45dd74aab7f
https://doi.org/10.1016/j.ygyno.2007.03.039
https://doi.org/10.1016/j.ygyno.2007.03.039
Publikováno v:
Cancer. 111:1-14
Cervical cancer is the second most common cancer in women worldwide. Human papillomavirus (HPV) is the etiologic agent for the vast majority of premalignant and malignant lesions, and high-risk HPV types can be detected in almost all cases of cervica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d335a65c91e5541472cd7d225275af9d
https://doi.org/10.1002/cncr.22425
https://doi.org/10.1002/cncr.22425
Publikováno v:
Clinical Cancer Research. 10:3147-3155
Purpose: The purpose of our study was to develop and validate an isogenic cell line pair that differs only in the expression of NAD(P)H:quinone oxidoreductase (NQO1) that can be used to examine the in vitro and in vivo role of NQO1 in the bioactivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc1f2397dfe3dab0f941a2858dff5a0c
https://doi.org/10.1158/1078-0432.ccr-03-0411
https://doi.org/10.1158/1078-0432.ccr-03-0411
Autor:
David Siegel, Preecha Boonchoong, Lawrence J. Berliner, David Ross, Jin Yi Han, Daniel L. Gustafson, Donna L. Dehn
Publikováno v:
Molecular Pharmacology. 65:1238-1247
Experiments using purified recombinant human NAD(P)H:quinone oxidoreductase 1 (NQO1) revealed that the auto-oxidation of fully reduced protein resulted in a 1:1 stoichiometry of oxygen consumption to NADH oxidation with the production of hydrogen per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a3871a9d97d6f8cf1dd723cfb1b81d
https://doi.org/10.1124/mol.65.5.1238
https://doi.org/10.1124/mol.65.5.1238
Autor:
David Siegel, David Ross, Luo Jia Tang, Jadwiga K. Kepa, Donna L. Dehn, Adil Anwar, Jennifer A. Pietenpol
Publikováno v:
Journal of Biological Chemistry. 278:10368-10373
NAD(P)H:quinone oxidoreductase 1 (NQO1) has been proposed to stabilize p53 via a redox mechanism involving oxidation of NAD(P)H as a consequence of the catalytic activity of NQO1. We report that treatment of HCT-116 human colon carcinoma cells with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8f4a5699338fc8df09ed28d5e8fb10
https://doi.org/10.1074/jbc.m211981200
https://doi.org/10.1074/jbc.m211981200
Autor:
Christopher J. Moody, Donna L. Dehn, John Butler, David Ross, Shannon L. Winski, Elizabeth Swann, Robert H J Hargreaves
Publikováno v:
Biochemical Pharmacology. 61:1509-1516
To investigate the importance of NAD(P)H:quinone oxidoreductase 1 (or DT-diaphorase; NQO1) in the bioactivation of antitumor quinones, we established a series of stably transfected cell lines derived from BE human colon adenocarcinoma cells. BE cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fa804f96b922ebabf63eb816fb6d80c
https://doi.org/10.1016/s0006-2952(01)00631-1
https://doi.org/10.1016/s0006-2952(01)00631-1
Autor:
S. Mark Roe, Chrisostomos Prodromou, Chuan-Hsin Chang, Rui Xiong, Christopher J. Moody, David Siegel, Russell R. A. Kitson, Huw E. L. Williams, Donna L. Dehn, David Ross, Adrienne L. Davis, William Lewis
Publikováno v:
Nature chemistry. 5(4)
The benzoquinone ansamycin geldanamycin and its derivatives are inhibitors of heat shock protein Hsp90, an emerging target for novel therapeutic agents both in cancer and in neurodegeneration. However, the toxicity of these compounds to normal cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089801371ce48279f3923419d382c012
https://pubmed.ncbi.nlm.nih.gov/23511419
https://pubmed.ncbi.nlm.nih.gov/23511419
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 334(1)
NAD(P)H:quinone oxidoreductase 1 (NQO1) deficiency resulting from a homozygous NQO1*2 polymorphism has been associated with an increased risk of benzene-induced myeloid toxicity and a variety of de novo and therapy-induced leukemias. Endothelial cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411ef5e076ff52d1b9108a89aec14c55
https://pubmed.ncbi.nlm.nih.gov/20378716
https://pubmed.ncbi.nlm.nih.gov/20378716