Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Donna L Senger"'
Autor:
Alain Tremblay, Ranjani Somayaji, Arthur Lau, Fatma Eser, Rahmet Guner, David R Luke, Ŏ Fehmi Tabak, Mark Hepokoski, Nancy Gardetto, Steven A Conrad, Sunil D Kumar, Kalyan Ghosh, Stephen M Robbins, Donna L Senger, Daisy Sun, Rachel K S Lim, Jonathan Liu, Ridvan Karaali, Daniel Muruve
Publikováno v:
BMJ Open, Vol 14, Iss 3 (2024)
Objective Dipeptidase-1 (DPEP-1) is a recently discovered leucocyte adhesion receptor for neutrophils and monocytes in the lungs and kidneys and serves as a potential therapeutic target to attenuate inflammation in moderate-to-severe COVID-19. We aim
Externí odkaz:
https://doaj.org/article/ce794de0f6f943398e235ef10b530862
Autor:
Alice L Yuan, Christian B Ricks, Alexandra K Bohm, Xueqing Lun, Lori Maxwell, Shahana Safdar, Shazreh Bukhari, Amanda Gerber, Wajid Sayeed, Elizabeth A Bering, Haley Pedersen, Jennifer A Chan, Yaoqing Shen, Marco Marra, David R Kaplan, Warren Mason, Lindsey D Goodman, Ravesanker Ezhilarasan, Ascher B Kaufmann, Matthew Cabral, Steve M Robbins, Donna L Senger, Daniel P Cahill, Erik P Sulman, J Gregory Cairncross, Michael D Blough
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202860 (2018)
BACKGROUND:Temozolomide (TMZ) is active against glioblastomas (GBM) in which the O6-methylguanine-DNA methyltransferase (MGMT) gene is silenced. However, even in responsive cases, its beneficial effect is undermined by the emergence of drug resistanc
Externí odkaz:
https://doaj.org/article/10de965f01cd437d8f49e05f6bc97413
Autor:
Juan C Corredor, Nicole Redding, Karen Bloté, Stephen M Robbins, Donna L Senger, John C Bell, Paul Beaudry
Publikováno v:
Molecular Therapy: Oncolytics, Vol 3, Iss C (2016)
N-myc oncogene amplification is associated but not present in all cases of high-risk neuroblastoma (NB). Since oncogene expression could often modulate sensitivity to oncolytic viruses, we wanted to examine if N-myc expression status would determine
Externí odkaz:
https://doaj.org/article/dae86ddfa92a41d4b3c958b114f15ffc
Autor:
LiMei Wang, Jennifer J Rahn, XueQing Lun, Beichen Sun, John J P Kelly, Samuel Weiss, Stephen M Robbins, Peter A Forsyth, Donna L Senger
Publikováno v:
PLoS Biology, Vol 6, Iss 11, p e289 (2008)
The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. Here, we show that neurotrophin-dependent regulated intramembrane proteolysis
Externí odkaz:
https://doaj.org/article/98d550cb27f54275989b23eb6180621d
Autor:
Angela L M Johnston, Xueqing Lun, Jennifer J Rahn, Abdelhamid Liacini, Limei Wang, Mark G Hamilton, Ian F Parney, Barbara L Hempstead, Stephen M Robbins, Peter A Forsyth, Donna L Senger
Publikováno v:
PLoS Biology, Vol 5, Iss 8, p e212 (2007)
The invasive nature of cancers in general, and malignant gliomas in particular, is a major clinical problem rendering tumors incurable by conventional therapies. Using a novel invasive glioma mouse model established by serial in vivo selection, we id
Externí odkaz:
https://doaj.org/article/33ea284446f5469189343a2d90b1d815
Autor:
Elham Karimi, Miranda W. Yu, Sarah M. Maritan, Lucas J. M. Perus, Morteza Rezanejad, Mark Sorin, Matthew Dankner, Parvaneh Fallah, Samuel Doré, Dongmei Zuo, Benoit Fiset, Daan J. Kloosterman, LeeAnn Ramsay, Yuhong Wei, Stephanie Lam, Roa Alsajjan, Ian R. Watson, Gloria Roldan Urgoiti, Morag Park, Dieta Brandsma, Donna L. Senger, Jennifer A. Chan, Leila Akkari, Kevin Petrecca, Marie-Christine Guiot, Peter M. Siegel, Daniela F. Quail, Logan A. Walsh
Publikováno v:
Nature. 614:555-563
Single-cell technologies have enabled the characterization of the tumour microenvironment at unprecedented depth and have revealed vast cellular diversity among tumour cells and their niche. Anti-tumour immunity relies on cell–cell relationships wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b9df3c153f236e9fef94143d4a55b75
https://doi.org/10.1038/s41586-022-05680-3
https://doi.org/10.1038/s41586-022-05680-3
Autor:
Ana Nikolic, Francesca Maule, Anna Bobyn, Katrina Ellestad, Seungil Paik, Sajid A. Marhon, Parinaz Mehdipour, Xueqing Lun, Huey-Miin Chen, Claire Mallard, Alexander J. Hay, Michael J. Johnston, Christopher J. Gafuik, Franz J. Zemp, Yaoqing Shen, Nicoletta Ninkovic, Katalin Osz, Elodie Labit, N. Daniel Berger, Duncan K. Brownsey, John J. Kelly, Jeff Biernaskie, Peter B. Dirks, Darren J. Derksen, Steven J. M. Jones, Donna L. Senger, Jennifer A. Chan, Douglas J. Mahoney, Daniel D. De Carvalho, Marco Gallo
Publikováno v:
Nature Communications. 14
Self-renewal is a crucial property of glioblastoma cells that is enabled by the choreographed functions of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could therefore represent an impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d553f8e11d60b96d6809f5e74504db2e
https://doi.org/10.1038/s41467-023-38919-2
https://doi.org/10.1038/s41467-023-38919-2
Autor:
Donna L. Senger, Stephen M. Robbins, David R. Kaplan, J. Gregory Cairncross, Samuel Weiss, Artee Luchman, Jacob C. Easaw, Jeffrey L. Wrana, Alessandro Datti, David Uehling, Ahmed Aman, Xiuling Wang, Ngoc-Ha Dang, Xiaoguang Hao, Jennifer C. King, Natalie Grinshtein, J. Connor Wells, Xueqing Lun
Purpose: Glioblastoma is one of the most lethal cancers in humans, and with existing therapy, survival remains at 14.6 months. Current barriers to successful treatment include their infiltrative behavior, extensive tumor heterogeneity, and the presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352984f9333967436036ef5f69a99520
https://doi.org/10.1158/1078-0432.c.6523565.v1
https://doi.org/10.1158/1078-0432.c.6523565.v1
Autor:
Peter A. Forsyth, Donna L. Senger, Jaclyn A. Biegel, Grant McFadden, John W. Barrett, John C. Bell, Beichen Sun, Limei Wang, Hongyuan Zhou, Xueqing Lun, Yushui Wu
Purpose: Rhabdoid tumors are highly aggressive pediatric tumors that are usually refractory to available treatments. The purpose of this study was to evaluate the therapeutic potential of two oncolytic viruses, myxoma virus (MV) and an attenuated ves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732603b085ee1c07c88da1f79b2e1cfc
https://doi.org/10.1158/1078-0432.c.6517078
https://doi.org/10.1158/1078-0432.c.6517078
Autor:
V. Wee Yong, Stephen M. Robbins, Donna L. Senger, Wu Wei, Franz J. Zemp, Reza Mirzaei, Susobhan Sarkar
Oncogenic signaling by NOTCH is elevated in brain tumor-initiating cells (BTIC) in malignant glioma, but the mechanism of its activation is unknown. Here we provide evidence that tenascin-C (TNC), an extracellular matrix protein prominent in malignan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6b1f23ff7e1306e2ed8a74ee022bb01
https://doi.org/10.1158/0008-5472.c.6508760.v1
https://doi.org/10.1158/0008-5472.c.6508760.v1