Výsledky vyhledávání - "Donna L Senger"

Akademický článek

Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma

Autor: Varsha Thoppey Manoharan, Aly Abdelkareem, Gurveer Gill, Samuel Brown, Aaron Gillmor, Courtney Hall, Heewon Seo, Kiran Narta, Sean Grewal, Ngoc Ha Dang, Bo Young Ahn, Kata Osz, Xueqing Lun, Laura Mah, Franz Zemp, Douglas Mahoney, Donna L. Senger, Jennifer A. Chan, A. Sorana Morrissy

Publikováno v: Genome Biology, Vol 25, Iss 1, Pp 1-32 (2024)

Abstract Background Diffuse invasion of glioblastoma cells through normal brain tissue is a key contributor to tumor aggressiveness, resistance to conventional therapies, and dismal prognosis in patients. A deeper understanding of how components of t

Externí odkaz: https://doaj.org/article/f1033c8340dd4063abee32d40fee97cd

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Akademický článek

Multicentre, randomised, double-blind, placebo-controlled, proof of concept study of LSALT peptide as prevention of acute respiratory distress syndrome and acute kidney injury in patients infected with SARS-CoV-2 (COVID-19)

Autor: Alain Tremblay, Ranjani Somayaji, Arthur Lau, Fatma Eser, Rahmet Guner, David R Luke, Ŏ Fehmi Tabak, Mark Hepokoski, Nancy Gardetto, Steven A Conrad, Sunil D Kumar, Kalyan Ghosh, Stephen M Robbins, Donna L Senger, Daisy Sun, Rachel K S Lim, Jonathan Liu, Ridvan Karaali, Daniel Muruve

Publikováno v: BMJ Open, Vol 14, Iss 3 (2024)

Objective Dipeptidase-1 (DPEP-1) is a recently discovered leucocyte adhesion receptor for neutrophils and monocytes in the lungs and kidneys and serves as a potential therapeutic target to attenuate inflammation in moderate-to-severe COVID-19. We aim

Externí odkaz: https://doaj.org/article/ce794de0f6f943398e235ef10b530862

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Akademický článek

macroH2A2 antagonizes epigenetic programs of stemness in glioblastoma

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)

Abstract Self-renewal is a crucial property of glioblastoma cells that is enabled by the choreographed functions of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could therefore represent

Externí odkaz: https://doaj.org/article/028fa80da48448499589471060a20e19

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Akademický článek

To promote or inhibit glioma progression, that is the question for IL-33

Autor: Stephen M. Robbins, Donna L. Senger

Publikováno v: Cell Stress, Vol 5, Iss 1, Pp 19-22 (2020)

IL-33, a member of the IL-1 cytokine family has been shown to play a dual role within the body. First IL-33, similar to other IL-1 family members, is a secreted cytokine that binds to the cell surface receptor ST2 to induce a number of cell signaling

Externí odkaz: https://doaj.org/article/af9763f9fae24d3fb3314d67a24f91e0

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Akademický článek

Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-24 (2020)

Elevated levels of interleukin-33 have been associated with poor prognosis in patients with glioma. Here the authors show that glioma-derived IL-33 modulates a pro-tumorigenic immune microenvironment by activating resident and recruiting peripheral i

Externí odkaz: https://doaj.org/article/1b3e75d138fe4626bae55cdc8321e3d1

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Akademický článek

Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

Autor: Shawn T. Beug, Caroline E. Beauregard, Cristin Healy, Tarun Sanda, Martine St-Jean, Janelle Chabot, Danielle E. Walker, Aditya Mohan, Nathalie Earl, Xueqing Lun, Donna L. Senger, Stephen M. Robbins, Peter Staeheli, Peter A. Forsyth, Tommy Alain, Eric C. LaCasse, Robert G. Korneluk

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Smac mimetics sensitize cancer cells to the extrinsic cell death pathway and stimulate anti-tumour immunity. In this study, the authors show that Smac mimetics can synergize with immune checkpoint inhibitors to control tumour growth in mouse cancer m

Externí odkaz: https://doaj.org/article/153f1f0b72134cffba06e3aad0670491

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Data from Oncolytic Efficacy of Recombinant Vesicular Stomatitis Virus and Myxoma Virus in Experimental Models of Rhabdoid Tumors

Autor: Peter A. Forsyth, Donna L. Senger, Jaclyn A. Biegel, Grant McFadden, John W. Barrett, John C. Bell, Beichen Sun, Limei Wang, Hongyuan Zhou, Xueqing Lun, Yushui Wu

Purpose: Rhabdoid tumors are highly aggressive pediatric tumors that are usually refractory to available treatments. The purpose of this study was to evaluate the therapeutic potential of two oncolytic viruses, myxoma virus (MV) and an attenuated ves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732603b085ee1c07c88da1f79b2e1cfc
https://doi.org/10.1158/1078-0432.c.6517078

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