Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Donna L Bratton"'
Autor:
Kenneth C Malcolm, Silvia M Caceres, Kerstin Pohl, Katie R Poch, Audrey Bernut, Laurent Kremer, Donna L Bratton, Jean-Louis Herrmann, Jerry A Nick
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196120 (2018)
Mycobacterium abscessus, a rapidly growing nontuberculous mycobacterium, are increasingly present in soft tissue infections and chronic lung diseases, including cystic fibrosis, and infections are characterized by growth in neutrophil-rich environmen
Externí odkaz:
https://doaj.org/article/67d34abaaf054d289afd84d3a8511e67
Autor:
Saritha Suram, Lori J Silveira, Spencer Mahaffey, Gordon D Brown, Joseph V Bonventre, David L Williams, Neil A R Gow, Donna L Bratton, Robert C Murphy, Christina C Leslie
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69002 (2013)
The role of Group IVA cytosolic phospholipase A2 (cPLA2α) activation in regulating macrophage transcriptional responses to Candida albicans infection was investigated. cPLA2α releases arachidonic acid for the production of eicosanoids. In mouse res
Externí odkaz:
https://doaj.org/article/853cdc1284cb4115ac68686039ddd040
Autor:
Kenneth C Malcolm, E Michelle Nichols, Silvia M Caceres, Jennifer E Kret, Stacey L Martiniano, Scott D Sagel, Edward D Chan, Lindsay Caverly, George M Solomon, Paul Reynolds, Donna L Bratton, Jennifer L Taylor-Cousar, David P Nichols, Milene T Saavedra, Jerry A Nick
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57402 (2013)
Mycobacterium abscessus is a rapidly growing mycobacterium increasingly detected in the neutrophil-rich environment of inflamed tissues, including the cystic fibrosis airway. Studies of the immune reaction to M. abscessus have focused primarily on ma
Externí odkaz:
https://doaj.org/article/96a62966f26b4aed85d8cd8a41bed232
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72772 (2013)
Phosphatidylserine (PS) exposed on apoptotic cells has been shown to stimulate production of transforming growth factor-β (TGF-β) and promote anti-inflammatory responses. However, the PS receptor(s) responsible for this induction has not been clear
Externí odkaz:
https://doaj.org/article/8d76341a7cac4845a6e987d2598aa902
Autor:
Darlynn R Korns, S. Courtney Frasch, Ruby eFernandez-Boyanapalli, Peter M Henson, Donna L Bratton
Publikováno v:
Frontiers in Immunology, Vol 2 (2011)
A critical function of macrophages within the inflammatory milieu is the removal of dying cells by a specialized phagocytic process called efferocytosis (to carry to the grave). Through specific receptor engagement and induction of downstream signali
Externí odkaz:
https://doaj.org/article/330bedecd33f4dcb97162314e3f6861c
Autor:
Kelsey C. Haist, Sophie L. Gibbings, Jordan Jacobelli, Kara J. Mould, Peter M. Henson, Donna L. Bratton
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109589- (2024)
Summary: Sterile pyogranulomas and heightened cytokine production are hyperinflammatory hallmarks of Chronic Granulomatous Disease (CGD). Using peritoneal cells of zymosan-treated CGD (gp91phox−/−) versus wild-type (WT) mice, an ex vivo system of
Externí odkaz:
https://doaj.org/article/3319f50980b44809ac3b2750cd5c9663
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionLoss of NADPH oxidase activity results in proinflammatory macrophages that contribute to hyperinflammation in Chronic Granulomatous Disease (CGD). Previously, it was shown in a zymosan-induced peritonitis model that gp91phox-/- (CGD) mono
Externí odkaz:
https://doaj.org/article/73d155270d1d405cb161babfaf07b083
Autor:
Alexandra L. McCubbrey, Shannon A. McManus, Jazalle D. McClendon, Stacey M. Thomas, Hope B. Chatwin, Julie A. Reisz, Angelo D’Alessandro, Kara J. Mould, Donna L. Bratton, Peter M. Henson, William J. Janssen
Publikováno v:
Cell Reports. 38:110222
Phagocytosis of apoptotic cells, termed efferocytosis, is critical for tissue homeostasis and drives anti-inflammatory programming in engulfing macrophages. Here, we assess metabolites in naive and inflammatory macrophages following engulfment of mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd36e53c05ae256fd9b909d8563b35ab
https://doi.org/10.1016/j.celrep.2021.110222
https://doi.org/10.1016/j.celrep.2021.110222
Autor:
Donna L. Bratton, Peter M. Henson, S. Courtney Frasch, William J. Janssen, Alexandria L. McCubbrey, Michael P. Mohning, Stacey M. Thomas, Kara J. Mould, Lea Barthel
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 314:L69-L82
Microparticles are a newly recognized class of mediators in the pathophysiology of lung inflammation and injury, but little is known about the factors that regulate their accumulation and clearance. The primary objective of our study was to determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe72f4e26cf8dce3f2ffaa3cf8771dfd
https://doi.org/10.1152/ajplung.00058.2017
https://doi.org/10.1152/ajplung.00058.2017
Autor:
Brian P. O'Connor, Stacey M. Thomas, Sonia M. Leach, William J. Janssen, Julie A. Reisz, Claudia Jakubzick, Donna L. Bratton, Alexandra L. McCubbrey, Angelo D'Alessandro, Thomas Danhorn, Michael P. Mohning, Kara J. Mould, Lea Barthel, Tasha E. Fingerlin
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 57:294-306
Two populations of alveolar macrophages (AMs) coexist in the inflamed lung: resident AMs that arise during embryogenesis, and recruited AMs that originate postnatally from circulating monocytes. The objective of this study was to determine whether or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541fa0baaa4a47aeb335caef48b48cd1
https://doi.org/10.1165/rcmb.2017-0061oc
https://doi.org/10.1165/rcmb.2017-0061oc