Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Donna L, Livant"'
Autor:
Kathleen M. Woods Ignatoski, Navdeep K. Grewal, Sonja Markwart, Donna L. Livant, Stephen P. Ethier
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 5, Iss 2, Pp 128-134 (2003)
We have previously shown that human breast cancer cells that overexpress erbB-2 are growth factorindependent. In order to test the contribution of erbB2 to this and other transformed phenotypes without the genetic instability of cancer cells, erbB-2
Externí odkaz:
https://doaj.org/article/f6b5fa36f950403288dee93d2ebec07c
Autor:
Kenneth L. van Golen, LiWei Bao, George J. Brewert, Kenneth J. Pienta, Jeffrey M. Kamradt, Donna L. Livant, Sofia D. Merajver
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 4, Iss 5, Pp 373-379 (2002)
Plasma fibronectin-mediated invasion of human DU145 prostate cancer cell line was efficaciously inhibited in a rat tumor model by treatment with Ac-PHSCN-NH2 peptide. Invasion of DU145 cells was stimulated by the PHSCN sequence of plasma fibronectin.
Externí odkaz:
https://doaj.org/article/8c83376616db4fcca7604b93a1658aa3
Publikováno v:
Breast Cancer Research and Treatment. 157:489-501
At diagnosis, 10 % of breast cancer patients already have locally advanced or metastatic disease; moreover, metastasis eventually develops in at least 40 % of early breast cancer patients. Osteolytic bone colonization occurs in 80-85 % of metastatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5959936a51cc8cf7b953dd5f6aff76
https://doi.org/10.1007/s10549-016-3844-6
https://doi.org/10.1007/s10549-016-3844-6
Publikováno v:
Clinical & Experimental Metastasis. 31:379-393
Primary tumors often give rise to disseminated tumor cells (DTC's), which acquire full malignancy after invading distant site(s). Thus, DTC's may be a productive target for preventing prostate cancer metastasis progression. Our prior research showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67299d7dc022c11b9790adb437b97c1
https://doi.org/10.1007/s10585-013-9634-1
https://doi.org/10.1007/s10585-013-9634-1
Autor:
Donna M. Veine, Donna L. Livant, Kevin S. Fay, Zhao-Zhu Zeng, Evan D. Staszewski, Hongren Yao
Publikováno v:
Breast Cancer Research and Treatment. 125:363-375
The α5β1 integrin fibronectin receptor is an attractive therapeutic target in breast cancer because it plays key roles in invasion and metastasis. While its inactive form is widely expressed, activated α5β1 occurs only on tumor cells and their as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d582c76442815eaf69f3a3d49aab0078
https://doi.org/10.1007/s10549-010-0826-y
https://doi.org/10.1007/s10549-010-0826-y
Autor:
Donna M. Veine, Kevin S. Fay, Evan D. Staszewski, Zhao-Zhu Zeng, Hongren Yao, Donna L. Livant
Publikováno v:
Clinical & Experimental Metastasis. 27:173-184
Activated alpha5beta1 integrin occurs specifically on tumor cells and on endothelial cells of tumor-associated vasculature, and plays a key role in invasion and metastasis. The PHSCN peptide (Ac-PHSCN-NH(2)) preferentially binds activated alpha5beta1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4d0ae8ee8e818e85c82dadec8f3f79
https://doi.org/10.1007/s10585-010-9316-1
https://doi.org/10.1007/s10585-010-9316-1
Autor:
Kevin S. Fay, Aaron C. Spalding, Donna L. Livant, Korrene F. Rockwood, Sonja Markwart, Evan D. Staszewski, Hongren Yao, Zhao-Zhu Zeng
Publikováno v:
Translational Oncology. 2:8-20
Angiogenesis requires endothelial cell invasion and is crucial for wound healing and for tumor growth and metastasis. Invasion of native collagen is mediated by the alpha(5)beta(1) integrin fibronectin receptor. Thus, alpha(5)beta(1) up-regulation on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c329fcba3a31620c1883e32cbc2b74c1
https://doi.org/10.1593/tlo.08187
https://doi.org/10.1593/tlo.08187
Autor:
Donna L. Livant
Publikováno v:
Current Cancer Drug Targets. 5:489-503
The spread of cancer cells from the primary tumor to a distant site involves many of the invasive processes normally required for wound healing, including migration through the local connective tissue, invasion of the vasculature, extravasation, inva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd7acddeb408a2df6911146b262c79c
https://doi.org/10.2174/156800905774574002
https://doi.org/10.2174/156800905774574002
Autor:
Kathleen M. Woods Ignatoski, Zhao-Zhu Zeng, Yifeng Jia, Donna L. Livant, Stephen P. Ethier, Korrene F. Rockwood, Sonja Markwart
Publikováno v:
Cancer Research. 64:8674-8681
Integrins contribute to progression in many cancers, including breast cancer. For example, the interaction of alpha(5)beta(1) with plasma fibronectin causes the constitutive invasiveness of human prostate cancer cells. Inhibition of this process redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603cf588ccb7fb04728964505a482486
https://doi.org/10.1158/0008-5472.can-04-0069
https://doi.org/10.1158/0008-5472.can-04-0069
Autor:
Donna L. Livant, Kathleen M. Woods Ignatoski, Stephen P. Ethier, Navdeep K. Grewal, Sonja Markwart
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 5, Iss 2, Pp 128-134 (2003)
We have previously shown that human breast cancer cells that overexpress erbB-2 are growth factor-independent. In order to test the contribution of erbB-2 to this and other transformed phenotypes without the genetic instability of cancer cells, erbB-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64ab1638f39af7a893cb0cfe35f7019