Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Donna Kolber-Simonds"'
Autor:
Sharon McGonigle, Utpal Majumder, Donna Kolber-Simonds, Jiayi Wu, Andrew Hart, Thomas Noland, Karen TenDyke, Daniel Custar, Danyang Li, Hong Du, Maarten H. D. Postema, W. George Lai, Natalie C. Twine, Mary Woodall-Jappe, Kenichi Nomoto
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-14 (2019)
Abstract Background Chlorotoxin (Cltx) isolated from scorpion venom is an established tumor targeting and antiangiogenic peptide. Radiolabeled Cltx therapeutic (131I-TM601) yielded promising results in human glioma clinical studies, and the imaging a
Externí odkaz:
https://doaj.org/article/0260063af8414162a61d45c6971191f1
Autor:
Kenichi Nomoto, Mary Woodall-Jappe, Toshimitsu Uenaka, William H. Gerwick, Yoshihiko Kotake, Hajime Shimizu, Xiaojie Zhu, Hyeong-wook Choi, Steven Mathieu, Kuo-Ming Wu, Yongchun Shen, Karen Tendyke, Sergei Agoulnik, Krista Condon, Donna Kolber-Simonds, Sandeep Akare, Yimin Jiang, Zhihong Chen, Kuan-Chun Huang
Figure S1. Synthesis of [3H]apratoxin A. Figure S2. Synthesis of C.18-epi-apratoxin A. Figure S3. Apratoxin A in vitro IC50 against panels of human cancer cell lines. Table S1. Summary table for in vivo efficacy studies. Figure S4. Apratoxin A concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c65eb6f8b62874049a2fbbb2e9b798
https://doi.org/10.1158/1535-7163.22504099.v1
https://doi.org/10.1158/1535-7163.22504099.v1
Autor:
Kenichi Nomoto, Mary Woodall-Jappe, Toshimitsu Uenaka, William H. Gerwick, Yoshihiko Kotake, Hajime Shimizu, Xiaojie Zhu, Hyeong-wook Choi, Steven Mathieu, Kuo-Ming Wu, Yongchun Shen, Karen Tendyke, Sergei Agoulnik, Krista Condon, Donna Kolber-Simonds, Sandeep Akare, Yimin Jiang, Zhihong Chen, Kuan-Chun Huang
Apratoxin A is a natural product with potent antiproliferative activity against many human cancer cell lines. However, we and other investigators observed that it has a narrow therapeutic window in vivo. Previous mechanistic studies have suggested it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1702da5e1eb71b2ce4a697dd456e12e0
https://doi.org/10.1158/1535-7163.c.6537622.v1
https://doi.org/10.1158/1535-7163.c.6537622.v1
Autor:
Kenichi Nomoto, Mary Woodall-Jappe, Toshimitsu Uenaka, William H. Gerwick, Yoshihiko Kotake, Hajime Shimizu, Xiaojie Zhu, Hyeong-wook Choi, Steven Mathieu, Kuo-Ming Wu, Yongchun Shen, Karen Tendyke, Sergei Agoulnik, Krista Condon, Donna Kolber-Simonds, Sandeep Akare, Yimin Jiang, Zhihong Chen, Kuan-Chun Huang
Figure S1. Synthesis of [3H]apratoxin A. Figure S2. Synthesis of C.18-epi-apratoxin A. Figure S3. Apratoxin A in vitro IC50 against panels of human cancer cell lines. Table S1. Summary table for in vivo efficacy studies. Figure S4. Apratoxin A concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f53f6e76b6cb66b04a95e5af1c1cb98
https://doi.org/10.1158/1535-7163.22504102
https://doi.org/10.1158/1535-7163.22504102
Autor:
Kenichi Nomoto, Kuo Ming Wu, Xiaojie Zhu, Sergei Agoulnik, Donna Kolber-Simonds, Kuan-Chun Huang, Steven Mathieu, Toshimitsu Uenaka, Sandeep Akare, Yongchun Shen, Yoshihiko Kotake, William H. Gerwick, Zhihong Chen, Hyeong-Wook Choi, Karen TenDyke, Yimin Jiang, Krista Condon, Mary Woodall-Jappe, Hajime Shimizu
Publikováno v:
Molecular Cancer Therapeutics. 15:1208-1216
Apratoxin A is a natural product with potent antiproliferative activity against many human cancer cell lines. However, we and other investigators observed that it has a narrow therapeutic window in vivo. Previous mechanistic studies have suggested it
Autor:
Kenichi Nomoto, Kuan-Chun Huang, Donna Kolber-Simonds, Natalie C. Twine, George A. Moniz, Paul Chang, Jue-lon Shie, Jingzang Tao Miu, Karen Ackermann, Zhihong Chen, Sharon McGonigle, Jiayi Wu
Publikováno v:
Oncotarget
Impact Journals/National Center for Biotechnology Information (U.S.)
Impact Journals/National Center for Biotechnology Information (U.S.)
Inhibition of Poly(ADP-ribose) Polymerase1 (PARP1) impairs DNA damage repair, and early generation PARP1/2 inhibitors (olaparib, niraparib, etc.) have demonstrated clinical proof of concept for cancer treatment. Here, we describe the development of t
Autor:
Dae-Shik Kim, Atsushi Endo, Renee R. Hukkanen, Muzaffar Akram, Donna Kolber-Simonds, Karen TenDyke, Diana I. Albu, Shannon McGrath, Vaishali Dixit, Christy Ingersoll, David Verbel, Frank Fang, Thomas Noland, Janna Hutz, Mark Matijevic, Xingfeng Bao, Chi Zhang, Dinesh Chandra, Jiayi Wu, Kara A. Loiacono, John Wang, Hao Ming-Hong, Nadeem Sarwar, Kuan-Chun Huang
Publikováno v:
Cancer Research. 79:3269-3269
Introduction: We report discovery and characterization of E7766, a structurally novel STING agonist, as a potential immunotherapy for solid cancers through intratumoral (IT) administration and for Bacillus Calmette-Guerin (BCG) unresponsive non-muscl
Autor:
Atsushi ENDO, Dae-Shik Kim, Kuan-Chun Huang, Ming-Hong Hao, Steven Mathieu, Hyeong-wook Choi, Utpal Majumder, Xiaojie Zhu, Yongchun Shen, Kristen Sanders, Thomas Noland, Dinesh Chandra, Yu Chen, Karen TenDyke, Kara Loiacono, Donna Kolber-Simonds, Rongrong Jiang, Vaishali Dixit, Janna Hutz, John Wang, Xingfeng Bao, Francis Fang, Nadeem Sarwar
Publikováno v:
Cancer Research. 79:4456-4456
Introduction STING (stimulator of interferon genes) is an emerging target for cancer immunotherapy. 2’,3'-cGAMP, a natural cyclic dinucleotide (CDN) STING agonist, and its phosphorothioate analogs, have drawn broad attention as lead molecules for S
Autor:
Maarten H. D. Postema, Donna Kolber-Simonds, Daniel W. Custar, Thomas Noland, Kenichi Nomoto, Jiayi Wu, Vaishali Dixit, Danyang Li, W. George Lai, Karen TenDyke, Utpal Majumder, Hong Du, Sean Eckley, Sharon McGonigle, Mary Woodall-Jappe, Andrew Hart
Publikováno v:
Cancer Research. 78:3961-3961
Chlorotoxin is an established tumor targeting peptide that naturally occurs in scorpion venom. 131I-labelled chlorotoxin assessed in early phase human glioma clinical trials achieved promising results. A peptide drug conjugate (PDC) composed of chlor
Autor:
Robert J. Hawley, Clifton N. Murphy, Liangxue Lai, August Rieke, Scott Arn, David B. Carter, Jeffery M. Betthauser, Yanhong Hao, David J. J. Ryan, Randall S. Prather, Zhonghua Liu, Gi-Sun Im, David H. Sachs, Donna Kolber-Simonds, Maria Denaro, Erik Forsberg, Monica L. Augenstein, Julia L. Greenstein, Kwang-Wook Park, Greg D. Mell, Steven R. Watt
Publikováno v:
Proceedings of the National Academy of Sciences. 101:7335-7340
Hyperacute rejection of porcine organs by old world primate recipients is mediated through preformed antibodies against galactosyl-α-1,3-galactose (Galα-1,3-Gal) epitopes expressed on the pig cell surface. Previously, we generated inbred miniature