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The Effects of Ethanol on Striatal Dopamine and Frontal Cortical D-[3H]Aspartate Efflux Oscillate with Repeated Treatment Relevance to Individual Differences in Drug Responsiveness

Autor: Anthony R. Caggiula, Seymour M. Antelman, Alan M. Palmer, Susan Kiss, Donna Kocan, David J. Edwards

Publikováno v: Neuropsychopharmacology. 15:125-132

Numerous inconsistencies in the reported effects of drugs that can be found in both the human clinical and animal experimental literatures have prompted attempts to identify the basis of this variability. Our data suggest that one source may derive f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb064165c87265757138f3b30ed6a24
https://doi.org/10.1016/0893-133x(95)00174-c

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Long-term oscillation of corticosterone following intermittent cocaine

Autor: Samuel Gershon, Donna Kocan, David J. Edwards, Anthony R. Caggiula, Barbara J. Kucinski, Seymour M. Antelman, Susan Kiss

Publikováno v: Journal of neural transmission (Vienna, Austria : 1996). 107(3)

We have shown that repeated administration of cocaine, as well as other drugs and nondrug stressors, can induce alternating increases and decreases in several neurotransmitter and endocrine endpoints, which we call oscillation. Oscillation studies ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a63dec5af4706484dae0e8b3ab99855
https://pubmed.ncbi.nlm.nih.gov/10821445

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Neurochemical and physiological effects of cocaine oscillate with sequential drug treatment: possibly a major factor in drug variability

Autor: David J. Edwards, Anthony R. Caggiula, Seymour M. Antelman, Susan Kiss, Richard L. Stiller, Donna Kocan

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 12(4)

Variability in response to drug treatment is a poorly understood problem with severe consequences for both the individual and the health care delivery system. Our data suggest that one source of variability may be inherent in the way physiological sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0376405155bf7c94db98bcef96b02888
https://pubmed.ncbi.nlm.nih.gov/7576006

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One brief exposure to a psychological stressor induces long-lasting, time-dependent sensitization of both the cataleptic and neurochemical responses to haloperidol

Autor: Steven Knopf, Anthony R. Caggiula, Donna Kocan, Seymour M. Antelman, David J. Edwards

Publikováno v: Life sciences. 51(4)

Rats were exposed for 10 minutes to one of several enclosures graded in novelty. In one experiment they were then simply sacrificed and plasma corticosterone determinations made in order to obtain an index of the relative stressfulness of these enclo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f44b1ed5ff81789a502f38ea5f8fa35
https://pubmed.ncbi.nlm.nih.gov/1625517

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Amphetamine or haloperidol 2 weeks earlier antagonized the plasma corticosterone response to amphetamine; evidence for the stressful/foreign nature of drugs

Autor: Donna Kocan, David J. Edwards, Anthony R. Caggiula, Seymour M. Antelman, Steven Knopf

Publikováno v: Psychopharmacology. 107(2-3)

We inquired whether a single exposure to amphetamine (AM) or haloperidol (HALO) could modify the plasma corticosterone (CORT) response to a second injection of AM 2 weeks later. Male rats were injected with 4 mg/kgd-AM sulfate and tested for water in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c12a19d2e05594bc81e487e78efca27
https://pubmed.ncbi.nlm.nih.gov/1615134

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One experience with 'lower' or 'higher' intensity stressors, respectively enhances or diminishes responsiveness to haloperidol weeks later: implications for understanding drug variability

Autor: Steven Knopf, David J. Edwards, Herbert Barry, Donald R. Meyer, Seymour M. Antelman, Anthony R. Caggiula, Donna Kocan

Publikováno v: Brain research. 566(1-2)

The laboratory has previously shown that acute exposure to a variety of brief stressful events can have a very long-lasting influence on subsequent responsiveness to pharmacological and non-pharmacological stressors. In some cases the response to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b605c845b055cdf0570bac0767a9454
https://pubmed.ncbi.nlm.nih.gov/1814544

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Immobilization 12 days (but not one hour) earlier enhanced 2-deoxy-D-glucose-induced immunosuppression: evidence for stressor-induced time-dependent sensitization of the immune system

Autor: Steven Knopf, Donald T. Lysle, Anthony R. Caggiula, David J. Edwards, Bruce S. Rabin, Donna Kocan, Seymour M. Antelman, Joan E. Cunnick

Publikováno v: Progress in neuro-psychopharmacologybiological psychiatry. 14(4)

1. Prior exposure to a stressor can either increase or decrease subsequent behavioral, neurochemical, and endocrine reactivity to stress, depending on the pattern of stress exposure. 2. Massed or frequent exposures typically induce a reduction in rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0c3e013a43c11a3f87f2bf5982b7f1
https://pubmed.ncbi.nlm.nih.gov/2236585

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Persistent sensitization of clonidine-induced hypokinesia following one exposure to a stressor: possible relevance to panic disorder and its treatment

Autor: Donna Kocan, Seymour M. Antelman, David J. Edwards, Steven Knopf

Publikováno v: Psychopharmacology. 98:97-101

Based on previous findings of this laboratory that a single exposure to a stressful stimulus can induce a very long-lasting, sensitizing influence on the actions of drugs of multiple clinical and structural classes, the hypothesis was tested that a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effce9c1dfed5c3e487243fd0e9eb34d
https://doi.org/10.1007/bf00442013

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