Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Donna K. Dieckman"'
Autor:
Ken H. Ho, Edward L. Mattiuz, Ann Marie L. Ogden, Brian Michael Mathes, Ana I. Mateo, David Bleakman, Kevin John Hudziak, Donna K. Dieckman, Sandra Ann Filla, Mark A. Winter, Thomas J. Bleisch, Ana Maria Escribano, Paul L. Ornstein, Kirk W. Johnson, Douglas Richard Stack, Amy Clemens-Smith, Miriam del Prado, Ana M. Castaño, Mary A. Katofiasc, Robert E. Stratford, E. Dominguez, Michael Gregory Bell, Lee A. Phebus, Jose A. Martinez-Perez
Publikováno v:
Journal of Medicinal Chemistry. 45:4383-4386
Amino diacid 3, a highly selective competitive GluR5 kainate receptor antagonist, exhibited high GluR5 receptor affinity and selectivity over other glutamate receptors. Its diethyl ester prodrug 4 was orally active in two models of migraine: the neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40829499fc5f2801999006c9b4f877df
https://doi.org/10.1021/jm025548q
https://doi.org/10.1021/jm025548q
Publikováno v:
Gastroenterology. 106:624-628
Background/Aims: Erythromycin (EM-A) and some of its analogues stimulate gastrointestinal smooth muscle contractions. Because gastroesophageal reflux disease (GERD) in humans is in part caused by a reduction in lower esophageal sphincter (LES) pressu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f066ec5592110f4dc620d3af3673740
https://doi.org/10.1016/0016-5085(94)90694-7
https://doi.org/10.1016/0016-5085(94)90694-7
Autor:
Kirk W. Johnson, David Bleakman, Donna K. Dieckman, Paul L. Ornstein, Sandra Ann Filla, Kevin John Hudziak, Edward R. Siuda, Amy Clemens-Smith, Dell Colin Peter, Michael P. Johnson, Veronique Dehlinger, Eric S. Nisenbaum, Nabih M. Ramadan
Publikováno v:
Innovative drug development for headache disorders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::598d62a15eb1129e4f4cdc2ba1ab18a9
https://doi.org/10.1093/med/9780199552764.003.0022
https://doi.org/10.1093/med/9780199552764.003.0022
Autor:
David O. Calligaro, Amy Clemens-Smith, Ken H. Ho, Darryle D. Schoepp, Marlene L. Cohen, Mary Gates, Robert E. Stratford, Paul L. Ornstein, K.R Jarvie, Ann Marie L. Ogden, Sandra Ann Filla, Rebecca A. Wright, Mary A. Katofiasc, Brianne Weiss, Bryan G. Johnson, Geihan Rizkalla, Andrew Alt, Craig R. Salhoff, Kathryn W. Schenck, David Bleakman, Donna K. Dieckman, Kirk W. Johnson, Edward L. Mattiuz, Lee A. Phebus
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 318(2)
The excitatory neurotransmitter glutamate has been implicated in both migraine and persistent pain. The identification of the kainate receptor GLU(K5) in dorsal root ganglia, the dorsal horn, and trigeminal ganglia makes it a target of interest for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5211cdf990741fc3ac26cc363aeecbe0
https://pubmed.ncbi.nlm.nih.gov/16690725
https://pubmed.ncbi.nlm.nih.gov/16690725
Autor:
Smriti Iyengar, Philip Arthur Hipskind, Nixon James Arthur, Rosa Maria A. Simmons, Douglas A. Schober, Susan L. Gackenheimer, Dennis M. Zimmerman, Donald R. Gehlert, Bruce D. Gitter, Karen Lynn Lobb, John T. Catlow, Hamideh Zarrinmayeh, Donna K. Dieckman-McGinty, Robert F. Bruns, Thomas C. Britton, Steve Swanson
Publikováno v:
Journal of medicinal chemistry. 40(23)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2849a5f19d6f9d77decd21ea588d9ae1
https://pubmed.ncbi.nlm.nih.gov/9371234
https://pubmed.ncbi.nlm.nih.gov/9371234
Autor:
Lisa A. Shipley, Charles H. Mitch, Malcolm J. Sheardown, Steven James Quimby, John S. Ward, Kristian Tage Hansen, Per Sauerberg, Frank P. Bymaster, David O. Calligaro, Beverley Greenwood, Harlan E. Shannon, Donna K. Dieckman, Peter D. Suzdak, Thomas J. Brown, Michael D. B. Swedberg, Steven C. Peters, Leander Merrit, Preben H. Olesen
Publikováno v:
Journal of medicinal chemistry. 40(4)
Irritable bowel syndrome (IBS) is a pathopysiolocal condition characterized by abnormal bowel habits that are frequently accompanied by abdominal pain. Current therapy based on reducing high-amplitude GI contractions with nonselective muscarinic anta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9292e06707c4e58739cc60428e2668f4
https://pubmed.ncbi.nlm.nih.gov/9046345
https://pubmed.ncbi.nlm.nih.gov/9046345
Autor:
Patrick J. C. May, Bruce D. Gitter, Tinggui Yin, Thomas Edward Mabry, Paul A. Hyslop, Mark H. Bender, Donna K. Dieckman, James E. Audia, Nissen Jeffrey S, Weiying Li, Dan L. Czilli, Mcclure Don B, Leonard N. Boggs, Edward M. Johnstone, Sheila P. Little
Publikováno v:
Neurobiology of Aging. 25:S571
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b984b8aa0622894a79080f7b45987199
https://doi.org/10.1016/s0197-4580(04)81897-9
https://doi.org/10.1016/s0197-4580(04)81897-9
Autor:
David O. Calligaro, Donna K. Dieckman, Michael D. B. Swedberg, Steven C. Peters, Harlan E. Shannon, Lisa A. Shipley, Preben H. Olesen, Steven James Quimby, Leander Merritt, Per Sauerberg, Franklin Porter Bymaster, John S. Ward, Kristian Tage Hansen, Thomas J. Brown, Charles H. Mitch, Beverley Greenwood, Malcolm J. Sheardown
Publikováno v:
Life Sciences. 60:1201
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ebddba6ae0dcaefaf4206e073477bd4
https://doi.org/10.1016/s0024-3205(97)84374-3
https://doi.org/10.1016/s0024-3205(97)84374-3
Autor:
Neil W. DeLapp, Donna K. Dieckman
Publikováno v:
Journal of Investigative Dermatology. 90:490-494
Recent literature has suggested that pyroglutamate (PCA) formation in stratum corneum occurs by spontaneous cyclization of glutamine residues derived from filaggrin breakdown. This paper describes an enzymatic alternative. Epidermal homogenates from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79aaa97a4473f3da2553dbc928b97923
https://doi.org/10.1111/1523-1747.ep12460964
https://doi.org/10.1111/1523-1747.ep12460964
Autor:
Donna K. Dieckman, Neil W. DeLapp
Publikováno v:
Journal of Investigative Dermatology. 68(5):293-298
[ 3 H]Glutamic acid incorporated in vivo into hairless mouse epidermal pyrrolidone carboxylic acid (PCA) was followed with time after a single subcutaneous injection. PCA specific activity increased slowly, reaching a peak at 3 to 4 days after inject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e940f479974d9f697e55939a11f0d579