Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Donna J. Osterhout"'
Autor:
Kristen Swieck, Amanda Conta-Steencken, Frank A. Middleton, Justin R. Siebert, Donna J. Osterhout, Dennis J. Stelzner
Publikováno v:
BMC Neuroscience, Vol 20, Iss 1, Pp 1-20 (2019)
Abstract Background The spinal cord is limited in its capacity to repair after damage caused by injury or disease. However, propriospinal (PS) neurons in the spinal cord have demonstrated a propensity for axonal regeneration after spinal cord injury.
Externí odkaz:
https://doaj.org/article/ad2e13a35f5f4168b0c3847550a8c5f1
Autor:
Justin R. Siebert, Donna J. Osterhout
Publikováno v:
Journal of Neuroscience Research
Axonal damage and the subsequent interruption of intact neuronal pathways in the spinal cord are largely responsible for the loss of motor function after injury. Further exacerbating this loss is the demyelination of neighboring uninjured axons. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbc872615c4914af4157763a85eba46
https://doi.org/10.1002/jnr.24780
https://doi.org/10.1002/jnr.24780
Publikováno v:
Glia
Cells of the oligodendrocyte (OLG) lineage engage in highly motile behaviors that are crucial for effective central nervous system (CNS) myelination. These behaviors include the guided migration of OLG progenitor cells (OPCs), the surveying of local
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0aba57f8c09b0781fb45af04993d07e
https://pubmed.ncbi.nlm.nih.gov/31696982
https://pubmed.ncbi.nlm.nih.gov/31696982
Autor:
Frank A. Middleton, Dennis J. Stelzner, Amanda Conta-Steencken, Justin R. Siebert, Donna J. Osterhout, Kristen Swieck
Publikováno v:
BMC Neuroscience
BMC Neuroscience, Vol 20, Iss 1, Pp 1-20 (2019)
BMC Neuroscience, Vol 20, Iss 1, Pp 1-20 (2019)
Background The spinal cord is limited in its capacity to repair after damage caused by injury or disease. However, propriospinal (PS) neurons in the spinal cord have demonstrated a propensity for axonal regeneration after spinal cord injury. They can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd398203fd118cdc5ec9dd2875a39185
http://europepmc.org/articles/PMC6421714
http://europepmc.org/articles/PMC6421714
Publikováno v:
Cells Tissues Organs. 202:102-115
Nanoparticles are increasingly being studied within experimental models of spinal cord injury (SCI). They are used to image cells and tissue, move cells to specific regions of the spinal cord, and deliver therapeutic agents locally. The focus of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d677e5c21f4c2be6cc1eb997215416
https://doi.org/10.1159/000446647
https://doi.org/10.1159/000446647
Cauda equina repair in the rat: Part 3. Axonal regeneration across Schwann cell—Seeded collagen foam
Autor:
Samuel J. Mackenzie, Juneyoung L. Yi, Amit Singla, Blair Calancie, Donna J. Osterhout, Thomas Russell
Publikováno v:
Muscle & Nerve. 57
INTRODUCTION Treatments for patients with cauda equina injury are limited. METHODS In this study, we first used retrograde labeling to determine the relative contributions of cauda equina motor neurons to intrinsic and extrinsic rat tail muscles. Nex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2489dd534a09d366352513d0fd94dde5
https://doi.org/10.1002/mus.25751
https://doi.org/10.1002/mus.25751
Autor:
Justin R. Siebert, Donna J. Osterhout
Publikováno v:
Journal of Neurochemistry. 119:176-188
J. Neurochem. (2011) 119, 176–188. Abstract The formation of the glial scar following a spinal cord injury presents a significant barrier to the regenerative process. It is primarily composed of chondroitin sulfate proteoglycans (CSPGs) that can in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c0324f9d5a02bb37f4c2355c514a816
https://doi.org/10.1111/j.1471-4159.2011.07370.x
https://doi.org/10.1111/j.1471-4159.2011.07370.x
Autor:
Justin R. Siebert, Donna J. Osterhout
Publikováno v:
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology. 294:759-763
Oligodendrocyte (OL) progenitor cells (OPCs) give rise to the myelinating cells of the central nervous system (CNS), the OL. To examine molecular changes involved in OPC differentiation, a microarray analysis was performed at several time points duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4658cd1a53b5df48ad9085464f9d6b9f
https://doi.org/10.1002/ar.21370
https://doi.org/10.1002/ar.21370
Publikováno v:
BioMed Research International, Vol 2015 (2015)
BioMed Research International
BioMed Research International
While advances in technology and medicine have improved both longevity and quality of life in patients living with a spinal cord injury, restoration of full motor function is not often achieved. This is due to the failure of repair and regeneration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142c1cda214a9b3421f17831d0a94d52
https://doaj.org/article/9c413b6b34c94c22af7b88f1fc1bfcba
https://doaj.org/article/9c413b6b34c94c22af7b88f1fc1bfcba
Publikováno v:
Journal of Neuroscience Research. 69:24-29
Several studies have shown that the progression of oligodendrocyte progenitors along the lineage correlates with increased susceptibility to death stimuli. The molecular basis of this phenomenon remains unclear. This study demonstrates that the prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3454cc227bb2e01d392fc790af049535
https://doi.org/10.1002/jnr.10230
https://doi.org/10.1002/jnr.10230