Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Donna J. Freeman"'
Publikováno v:
Antiviral Research. 14:305-321
Topical antiviral chemotherapy has a number of potential advantages over systemic drug delivery for the treatment of cutaneous herpes simplex virus infections, including convenience; higher target tissue drug levels and greater efficacy; and specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a366980f689ec22da9d1259c9f7cb1f
https://doi.org/10.1016/0166-3542(90)90050-h
https://doi.org/10.1016/0166-3542(90)90050-h
Publikováno v:
Journal of Infectious Diseases. 162:299-305
Women attending family planning clinics in western Pennsylvania were enrolled into a prospective epidemiologic study of herpes simplex virus (HSV) infection. Detection of antibodies to HSV-1 and HSV-2 was based on an immunodot assay using type-specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8fbf4b9d66eb13f2022f568f6a2d5c
https://doi.org/10.1093/infdis/162.2.299
https://doi.org/10.1093/infdis/162.2.299
Autor:
Spotswood L. Spruance, Mark B. McKeough, J. C. B. Stewart, J. L. Cox, Donna J. Freeman, Nathaniel H. Rowe, V. J. Brightman, G Wenerstrom
Publikováno v:
Journal of Infectious Diseases. 161:191-197
In a double-blind, randomized, patient-initiated treatment study at five medical centers, 301 immunocompetent patients experiencing a recurrence of herpes labialis were treated with topical 15% idoxuridine (IDU) in dimethyl sulfoxide (DMSO), 80% DMSO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e1fde78100e54817b129ee512cf748
https://doi.org/10.1093/infdis/161.2.191
https://doi.org/10.1093/infdis/161.2.191
Publikováno v:
Antimicrobial Agents and Chemotherapy. 28:103-106
Three percent 5-ethyl-2'-deoxyuridine (EdU) in an aqueous cream base was compared with 5% acyclovir (ACV) in polyethylene glycol ointment and 3% EdU in 95% dimethyl sulfoxide (DMSO) for efficacy in the topical treatment of an experimental dorsal cuta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ebeadb4d3fa8bf716f853eddda10e0
https://doi.org/10.1128/aac.28.1.103
https://doi.org/10.1128/aac.28.1.103
Publikováno v:
International Journal of Pharmaceutics. 28:201-209
Topical formulations of the antiviral compound trifluorothymidine (TFT) were prepared with different proportions of Azone, propylene glycol (PG), polyethylene glycol (PEG-300) and/or water and evaluated by measuring in vitro diffusion of TFT through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7d3e70b01cbf231eaa7131d28b76bdb
https://doi.org/10.1016/0378-5173(86)90246-2
https://doi.org/10.1016/0378-5173(86)90246-2
Publikováno v:
Antimicrobial Agents and Chemotherapy. 29:730-732
Topical acyclovir (ACV) in polyethylene glycol (PEG) ointment has been disappointing in the treatment of recurrent herpes simplex virus infections in immunocompetent patients. To investigate the possible role of poor drug delivery from this formulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f549f29e030a0c07be42f871f1ec89e3
https://doi.org/10.1128/aac.29.5.730
https://doi.org/10.1128/aac.29.5.730
Publikováno v:
Antimicrobial Agents and Chemotherapy. 30:196-198
Topical foscarnet (PFA) and acyclovir (ACV) were compared in the dorsal cutaneous guinea pig model of herpes simplex virus type 1 infection. The relative order of efficacy was PFA cream greater than ACV cream greater than ACV ointment. In vitro studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142ea80e0b073eec8c8f64f9d103429a
https://doi.org/10.1128/aac.30.1.196
https://doi.org/10.1128/aac.30.1.196
Publikováno v:
The Journal of infectious diseases. 153(1)
Topical antiviral treatments for recurrent infection with herpes simplex virus in immunocompetent patients have been generally ineffective. We investigated whether in vitro drug measures could predict in vivo efficacy. Twelve topical antiviral formul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9607215e08ba73b9a54fd790e78940
https://pubmed.ncbi.nlm.nih.gov/3079810
https://pubmed.ncbi.nlm.nih.gov/3079810
Publikováno v:
Clinical pharmacology and therapeutics. 38(1)
Butylated hydroxytoluene (BHT) is a hydrophobic compound with in vitro activity against many enveloped viruses, including herpes simplex virus. The effect of topical therapy with 15% BHT in mineral oil on the course of recurrent herpes simplex labial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9a5da5c429eb344274418ca168568a
https://pubmed.ncbi.nlm.nih.gov/2988845
https://pubmed.ncbi.nlm.nih.gov/2988845
Publikováno v:
Antiviral research. 5(3)
The potential efficacy of topical therapy with (E)-5-w-bromovinyl)-2'-deoxyuridine (BVDU) for cutaneous herpesvirus infection was evaluated in vitro and in guinea pigs. Drug sensitivity testing against herpes simplex virus type 1 strain E115 revealed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d26f817b21b99f196ed62766136730
https://pubmed.ncbi.nlm.nih.gov/2992371
https://pubmed.ncbi.nlm.nih.gov/2992371